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these results show that angiotensin II and hypoxia, signals common to heart failure, result in increased LUC7L3 and RBM25 splicing regulators, increased binding of RBM25 to SCN5A (show SCN5A Proteins) mRNA, increased SCN5A (show SCN5A Proteins) splice variant abundances, decreased full-length SCN5A (show SCN5A Proteins) mRNA and protein, and decreased Na(+) current.
RBM25/LUC7L3-mediated abnormal SCN5A (show SCN5A Proteins) mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death.
These results suggest that cisplatin affects RNA splicing by changing the subnuclear distribution of proteins including cisplatin resistance-associated overexpressed protein (CROP).
Luc7A is a new U1 snRNP (show LSM2 Proteins)-associated splicing factor (show SLU7 Proteins).
This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
cisplatin resistance-associated overexpressed protein
, cisplatin resistance-associated-overexpressed protein
, luc7-like protein 3
, Cisplatin resistance-associated overexpressed protein
, CRE-associated protein 1
, cAMP regulatory element-associated protein 1
, cisplatin resistance associated overexpressed protein
, okadaic acid-inducible phosphoprotein OA48-18