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Multivariable analyses on time to relapse and OS revealed pre-transplant NPM1 MRD levels >1% as an independent prognostic factor for poor survival after allogeneic HSCT, whereas FLT3 (show FLT3 ELISA Kits)-ITD had no impact. Notably, outcome of patients with pre-transplant NPM1 MRD positivity >1% was as poor as that of patients transplanted with RD.
Our results indicate that CD4 (show CD4 ELISA Kits) expression and older age are adverse prognostic factors in wild-type NPM1, FLT3 (show FLT3 ELISA Kits)-ITD-negative CN-AML (show RUNX1 ELISA Kits).
NPM1-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 ELISA Kits) activation cascade.
Data indicate that NPM-ALK (show ALK ELISA Kits) was distributed in equal amounts between the cytoplasm and the nucleus.
The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. [review]
revealed that the localization of fluorescently labeled NPM is affected by the interaction between various forms of the protein
value of mutated NPM1 in AML (show RUNX1 ELISA Kits) in risk assessment and evaluating prognosis
NPM1 downregulation by P-STAT5 (show STAT5A ELISA Kits) is mediated by impairing the BRCA1-BARD1 (show BARD1 ELISA Kits) ubiquitin ligase, which controls the stability of NPM1. In turn, decreased NPM1 levels led to suppression of p53 (show TP53 ELISA Kits) expression, resulting in enhanced cell survival.
These results suggest that the p38/NPM/PP2A complex acts as a dynamic sensor, allowing endothelial cells to react rapidly to acute oxidative stress.
Nucleophosmin-anaplastic lymphoma kinase (show ALK ELISA Kits) serves as the founding member of the ALK (show ALK ELISA Kits) fusion protein family, and its role in malignant cell transformation is by far the best characterized and, thus, is the main focus of this review. [review]
Results suggest that some polymorphisms in NPM1 are associated with body weight at some ages and may be used as candidates for marker-assisted selection and management in beef cattle breeding programmes.
The NPM1 gene is a candidate gene for growth traits in cattle.
molecular complementarity underlies the higher frequency and significantly worse prognosis associated with NPM1c/FLT3 (show FLT3 ELISA Kits)-internal tandem duplications vs NPM1 (show GJA1 ELISA Kits)/NRAS (show NRAS ELISA Kits)-G12D-mutant acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) and functionally confirm the role of HOXA genes in NPM1c-driven AML (show RUNX1 ELISA Kits).
NPM1 (show GJA1 ELISA Kits)-dependent nucleolar PIDDosome is a key initiator of the caspase-2 (show CASP2 ELISA Kits) activation cascade.
NPM1 (show GJA1 ELISA Kits) knockdown decreased NF-kappaB (show NFKB1 ELISA Kits)-mediated transcription of selected target genes by decreasing the recruitment of NF-kappaB (show NFKB1 ELISA Kits) p65 (show NFkBP65 ELISA Kits) to the gene promoters.
study suggests that although neurons need NPM1 (show GJA1 ELISA Kits) for survival, an increase in its expression beyond physiological levels and its translocation to the cytoplasm leads to death through abortive cell cycle induction.
The levels of B23 expression are directly regulated by EGR1 (show EGR1 ELISA Kits).
IDH2 (show IDH2 ELISA Kits) and NPM1 (show GJA1 ELISA Kits) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A ELISA Kits) stem-like cells.
Lrrc34, a novel nucleolar protein (show MCRS1 ELISA Kits), interacts with npm1 (show GJA1 ELISA Kits) and ncl (show NCL ELISA Kits) and has an impact on pluripotent stem cells
a function of NPM1 (show GJA1 ELISA Kits) in the spatial organization of nucleolus-associated heterochromatin through DNA methyltransferase (show DNMT1 ELISA Kits) DNMT3A (show DNMT3A ELISA Kits)
The data presented here support a novel role for NPM1 (show GJA1 ELISA Kits) as a multilevel modulator of the base excision repair pathway.
The mechanism of G-CSF's neuroprotection may be related in part to attenuating neuronal apoptosis by NPM1 (show GJA1 ELISA Kits).
NLP is essential for the positioning of centromeres during cell division in Drosophila.
This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
, nucleophosmin/nucleoplasmin, 4
, nucleolar protein NO38
, nucleophosmin/nucleoplasmin family, member 1
, nucleolar phosphoprotein B23
, nucleolar protein B23.1
, nucleophosmin 1
, chromatin decondensation protein 1