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Suggest that during heart disease nucleolin is reactivated to mobilize conserved aspects of chromatin remodeling and gene expression.
Disruption of the AtNUC-L1 gene induces loss of symmetrical DNA methylation (show HELLS ELISA Kits) without affecting histone epigenetic marks at rRNA genes.
PARL1 protein has roles similar to those of the yeast nucleolin in nuclear signal recognition, ribosomal processing, and ribosomal subunit accumulation.
NCL (show CLN5 ELISA Kits) was associated with bipolar disorder.
Nucleolin both forms an mRNP complex with the eIF4G (show EIF4G1 ELISA Kits) and CSF-1 (show CSF1 ELISA Kits) mRNA, and is co-localized with the eIF4G (show EIF4G1 ELISA Kits) in the cytoplasm further supporting nucleolin's role in translational regulation.
Identified the regulator of ribosome production nucleolin (NCL) as over-expressed in AML (show RUNX1 ELISA Kits) blasts. Moreover, we found in two series that high NCL (show CLN5 ELISA Kits) mRNA expression level was associated with a poor overall survival, particular in elderly patients.
Data suggest a 216-nucleotide proximal cis (show CISH ELISA Kits)-element in LIF (show LIF ELISA Kits) mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH ELISA Kits)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin and PCBP1 (show PCBP1 ELISA Kits), 2 trans-acting factors that bind to and stabilize LIF (show LIF ELISA Kits) mRNA. [LIF (show LIF ELISA Kits) = leukemia inhibitory factor (show LIF ELISA Kits); PCBP1 (show PCBP1 ELISA Kits) = poly(rC) binding protein 1 (show PCBP1 ELISA Kits)]
Data suggest that C11orf98 microprotein, NPM1 (show NPM1 ELISA Kits), and nucleolin interact and colocalize in the cell nucleolus. (C11orf98 = chromosome 11 open reading frame 98 protein; NPM1 (show NPM1 ELISA Kits) = nucleophosmin 1 (show NPM1 ELISA Kits))
nucleolin inhibition is a new anti-pancreatic cancer therapeutic strategy that dually blocks tumor progression and normalizes tumor vasculature in pancreatic ductal adenocarcinoma
It has been found that during microtubule growth phases, nucleolin affects both the speed and life time of microtubule polymerization.
Interaction of Host Nucleolin with Influenza A Virus Nucleoprotein in the Early Phase of Infection Limits the Late Viral Gene Expression
A yeast display library based on an engineered IgG1 CH2 (show Acyp1 ELISA Kits) scaffold with diversified loop regions was constructed, and CH2 (show Acyp1 ELISA Kits) binders were isolated by panning against nucleolin.
A portion of HS-anMan colocalized with nucleolin at small discrete sites, while most of the nucleolin and nascent RNA was dispersed. In U87 cells, HS-anMan, nucleolin and nascent RNA reassembled after prolonged hypoxia.
Data indicate alpha-P85 (show ECM1 ELISA Kits) Subunit, PI-3K (p85alpha) as a positive regulator of epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) expression and cell malignant transformation via nucleolin-dependent mechanism.
Nucleolin protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 (show ABCA1 ELISA Kits) expression.
Nucleolin Acts as a Scavenger Receptor for Acetylated Low-Density Lipoprotein on Macrophages
Nucleolin is a receptor for maleylated-bovine serum albumin (show ALB ELISA Kits) on macrophages
Lrrc34, a novel nucleolar protein (show MCRS1 ELISA Kits), interacts with npm1 (show GJA1 ELISA Kits) and ncl and has an impact on pluripotent stem cells
results indicate that nucleolin is a receptor that allows macrophages to recognize toxic Advanced glycosylation end-products.
results for the first time demonstrate that nucleolin-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha (show GADD45A ELISA Kits) mRNA binding activity.
Nucleolin-FGF1 interaction is critical for the intranuclear phosphorylation of FGF1 by PKCdelta and thereby the regulation of nuclear export of FGF1.
ANKRD1 (show ANKRD1 ELISA Kits), in association with factors such as nucleolin, represses MMP13 (show MMP13 ELISA Kits) transcription. Ankrd1 (show ANKRD1 ELISA Kits) deletion additionally relieved MMP10 (show MMP10 ELISA Kits) transcriptional repression
Data show that si-RNA induced down-regulation of FUT1 (show FUT1 ELISA Kits) and FUT2 (show FUT2 ELISA Kits) reduced expression of fucosylated nucleolin glycoforms and their exposure at the cell surface.
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20.
, eukaryotic translation initiation factor 3 subunit A
, Eukaryotic translation initiation factor 3 subunit 10
, nucleolin-like protein
, protein C23