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PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology
Data highlight the importance of the catalytic activity of PIMT to mediate VEGF effects during endothelial cell migration and tube formation in angiogenesis.
Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma.
The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death
ERK2 (show MAPK1 Antibodies)-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP (show TGS1 Antibodies) at Ser298 augments hepatic gluconeogenesis.
Overexpression of PCMT1 attentuates Mst1 (show MST1 Antibodies) kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes.
PIMT was identified as a key player responsible for glycated low density lipoproteins induced vascular endothelial cell apoptosis.
Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp (show ASIP Antibodies), and is able to restore Arabidopsis PRH75 (show DDX46 Antibodies)'s complex biochemical activity provided isoAsp formation has not led to conformational alterations.
Data show six differentially expressed proteins were identified as HSP70 (show HSP70 Antibodies), PPIA (show PPIA Antibodies) and alpha-Enolase (show ENO1 Antibodies) (up-regulated) S100-A9, PIMT and beta-5 tubulin (show TUBB Antibodies) (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis.
The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang.
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
L-isoaspartyl protein carboxyl methyltransferase
, protein L-isoaspartyl/D-aspartyl methyltransferase
, protein-L-isoaspartate(D-aspartate) O-methyltransferase
, protein-beta-aspartate methyltransferase
, CLL-associated antigen KW-2
, PRIP-interacting protein PIPMT
, PRIP-interacting protein with methyltransferase domain
, PRIP-interacting protein with methyltransferase motif
, cap-specific guanine-N2 methyltransferase
, hepatocellular carcinoma-associated antigen 137
, nuclear receptor coactivator 6 interacting protein
, nuclear receptor coactivator 6-interacting protein
, trimethylguanosine synthase
, trimethylguanosine synthase homolog