Browse our serine Dehydratase Proteins (SDS)

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serine Dehydratase Proteins (SDS)
On are 6 serine Dehydratase (SDS) Proteins from 4 different suppliers available. Additionally we are shipping serine Dehydratase Antibodies (53) and serine Dehydratase Kits (12) and many more products for this protein. A total of 78 serine Dehydratase products are currently listed.
4432411H13Rik, 4733401P19Rik, AI836084, CGI-97, CWS2, IP, PGL4, RATSDHE1, Sdh, SDH1, SDH2, Sdhe1, SDHIP, SDS, TDH
list all proteins Gene Name GeneID UniProt
SDS 10993 P20132
SDS 231691 Q8VBT2
SDS 25044 P09367

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serine Dehydratase Proteins (SDS) by Origin

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Human serine Dehydratase (SDS) interaction partners

  1. SDHB (show SDHB Proteins)-related tumours are picked up as early as 2 years after initial negative surveillance scan

  2. miR (show MLXIP Proteins)-183 cluster (miR (show MLXIP Proteins)-96/182/183) are related to clinical parameters and SDHB (show SDHB Proteins) expression in pheochromocytomas.

  3. In SDHB (show SDHB Proteins) mutation carriers, a lower rate of metastatic disease and a higher number of head and neck paragangliomas compared to previous reports was observed in a nationwide study in the Netherlands.

  4. Loss of FH immunohistochemical (IHC) expression in cutaneous leiomyomas is a sensitive and specific marker for detection of hereditary leiomyomatosis and renal cell carcinoma (show MOK Proteins) (HLRCC (show FH Proteins)). FH expression by IHC was absent in 9 specimens and retained in 85 specimens and 2 cases were equivocal with minimal FH expression while succinate dehydrogenase B (show SDHB Proteins) expression was retained in 95 specimens and equivocal in 1 specimen.

  5. Identify small molecule binding to the succinate dehydrogenase subunit B (SDHB (show SDHB Proteins)) protein of complex II of the mitochondrial electron transfer chain to block mitochondrial apoptotic pathway.

  6. We have shown that ASO treatment diminished aberrant splicing and increased ISCU (show ISCU Proteins) protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (show SDHB Proteins) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  7. SDH-deficient gastrointestinal stromal tumors (GISTs) account for approximately 8% of gastric GISTs and are associated with a high rate of distant metastasis, regardless of conventional risk category.

  8. SDHB (show SDHB Proteins) mutation status and primary tumor size are predictive in patient outcome diagnosed with pheochromocytoma and abdominal paraganglioma.

  9. For classification, tumors were characterized by SDHA (show SDHA Proteins), B, C, or D (SDHX) mutations and other genetic and epigenetic alterations, including presence of mutations in germline

  10. Mutations in some enzymes of the TCA cycle: Isocitrate dehydrogenase (IDH (show IDH1 Proteins)), succinate dehydrogenase (SDH (show SDHA Proteins)) and fumarate hydratase (FH (show FH Proteins)) are associated with the accumulation of metabolites that are able to influence many aspects of cancer development and progression and for this reason are termed onco-metabolites.

Mouse (Murine) serine Dehydratase (SDS) interaction partners

  1. Deficiency of the ribosome biogenesis gene Sbds (show SBDS Proteins) in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes

  2. Sbds (show SBDS Proteins) genotypes correlated with phenotypes in a mouse model of Shwachman-Diamond syndrome. Defects developed specifically in the pancreata of mice, reducing growth of mice and production of digestive enzymes.

  3. Sbds (show SBDS Proteins) is required for osteoclastogenesis by regulating monocyte migration via Rac2 (show RAC2 Proteins) and osteoclast differentiation signaling downstream of RANK.

  4. Sbds (show SBDS Proteins) is an essential gene for early mammalian development, with an expression pattern consistent with a critical role in cell proliferation.

  5. loss of Sbds (show SBDS Proteins) is sufficient to induce abnormalities in hematopoiesis

  6. The majority of Shwachman-Diamond syndrome cases are results of mutations in SBDS (show SBDS Proteins) gene on chromosone 7q11.

serine Dehydratase (SDS) Protein Profile

Protein Summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Alternative names and synonyms associated with serine Dehydratase (SDS)

  • serine dehydratase (SDS)
  • serine dehydratase (sds)
  • serine dehydratase (Sds)
  • Shwachman-Bodian-Diamond syndrome homolog (human) (Sbds)
  • succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB)
  • 4432411H13Rik protein
  • 4733401P19Rik protein
  • AI836084 protein
  • CGI-97 protein
  • CWS2 protein
  • IP protein
  • PGL4 protein
  • RATSDHE1 protein
  • Sdh protein
  • SDH1 protein
  • SDH2 protein
  • Sdhe1 protein
  • SDHIP protein
  • SDS protein
  • TDH protein

Protein level used designations for serine Dehydratase Proteins (SDS)

serine dehydratase , L-serine dehydratase/L-threonine deaminase , L-serine ammonia-lyase , L-serine deaminase , L-serine dehydratase , L-threonine dehydratase , TDH , SDH , protein 22A3 , ribosome maturation protein SBDS , shwachman-Bodian-Diamond syndrome protein homolog , iron-sulfur subunit of complex II , succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

452274 Pan troglodytes
486281 Canis lupus familiaris
713285 Macaca mulatta
100036931 Xenopus laevis
100101671 Xenopus (Silurana) tropicalis
100155595 Sus scrofa
10993 Homo sapiens
231691 Mus musculus
25044 Rattus norvegicus
514346 Bos taurus
66711 Mus musculus
6390 Homo sapiens
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