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we identified a consistently replicated loci at 9q34.2 (rs633862 near ABO (show ABO Proteins) and SURF6, P(meta) = 8.57 x 10(-7)) (P<0.05 in all three stages)
the panel of the GST (show SLCO6A1 Proteins)-Surf6-dom (show SOX10 Proteins) protein partners, which were identified by mass-spectrometry, points to putative interactions of human SURF6 with a number of nuclear and nucleolar proteins of other functional groups
The observations suggest that nucleolar protein (show MCRS1 Proteins) SURF-6 can act as a marker of early T lymphocyte activation for proliferation and that it could participate in cell cycle regulation in mammals.
Surf6 is essential for mouse preimplantation development (show MTA2 Proteins), presumably by regulating ribosome biogenesis.
Expression of SURF-6 is essential for mammalian cell viability and cell cycle progression.
This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.
, surfeit locus protein 6
, surfeit gene 6