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Human PRTFDC1 Protein expressed in Escherichia coli (E. coli) - ABIN667475
Gauci, Helbig, Slijper, Krijgsveld, Heck, Mohammed: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. in Analytical chemistry 2009
Show all 2 references for ABIN667475
We found evidence for PRTFDC1 as a potential novel PTSD gene, a finding that awaits further replication.
These results demonstrate that PRTFDC1 is a genetic modifier of HPRT (show HPRT1 Proteins)-deficiency in the mouse.
The PRTFDC1 structure has been determined at 1.7 A resolution with bound GMP (show NT5C2 Proteins). The overall structure and GMP (show NT5C2 Proteins) binding mode are very similar to that observed for HPRT (show HPRT1 Proteins).
epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis.
Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
phosphoribosyl transferase domain containing 1
, phosphoribosyltransferase domain-containing protein 1
, hypoxanthine phosphoribosyltransferase
, HHGP protein