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Human Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN624940
Vizio, Biasi, Scirelli, Novarino, Prati, Ciuffreda, Montrucchio, Poli, Bellone: Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors. in Journal of translational medicine 2013
Show all 8 references for ABIN624940
Mouse (Murine) Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN1672851
Cheung, Stewart, Marsden: Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. in Genomics 1998
Show all 2 references for ABIN1672851
Shear stress activated Ang-2 via canonical Wnt (show WNT2 ELISA Kits) signaling in vascular endothelial cells, and Wnt (show WNT2 ELISA Kits)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
NDPKB (show NME1 ELISA Kits) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (show MLXIP ELISA Kits)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (show ANGPT1 ELISA Kits) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 ELISA Kits) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
This study identifies angiopoietin-2 as a link between kidney fibrosis and arterial stiffness.
vitamin D-VDR (show CYP27B1 ELISA Kits) signaling prevents lung injury by blocking the Ang-2-Tie-2 (show TEK ELISA Kits)-MLC kinase cascade and the renin (show REN ELISA Kits)-angiotensin system.
Angiopoietin-2 was expressed on lymphatic vessels and macrophages in inflamed cornea. While corneal LG response was abolished in Ang-2 knockout mice.
The Ang-1 (show ANGPT1 ELISA Kits), Ang-2, Tie-2 (show TEK ELISA Kits) system takes part in the pathologic processes in the brains that suffered acute carbon monoxide poisoning by participating in neovascularization.
These results suggested that IL-35 restrains rheumatoid arthritis angiogenesis and inflammation by downregulating basal and VEGF (show VEGFA ELISA Kits)-induced Ang2 secretion as well as disrupting Ang2/Tie2 (show TEK ELISA Kits) signal transduction.
High Ang 1 (show ANGPT1 ELISA Kits) expression in hilar cholangiocarcinoma and infiltration of TIE2 (show TEK ELISA Kits)-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion.
This study identified Ang-2 as an endothelial cell-derived regulator of BBB (show ALMS1 ELISA Kits) permeability.
Serum Ang-2 may be a relevant predictor of Acute Pancreatitis severity, in particular of the development of AP-renal syndrome.
the homeostasis of vascular endothelial function by Ang-1 (show ANGPT1 ELISA Kits) and Ang-2 is disrupted in macrophage activation syndrome (MAS (show MAS1 ELISA Kits)); the Ang-2/1 ratio was significantly elevated in the active phase of s-JIA; serum Ang-1 (show ANGPT1 ELISA Kits) levels were significantly decreased in MAS (show MAS1 ELISA Kits), whereas the serum Ang-2 levels and the Ang-2/1 ratio were significantly elevated in MAS (show MAS1 ELISA Kits)
Data show that angiopoietin-2 (Ang-2) and bacterial endotoxins (LPS (show IRF6 ELISA Kits)) follow opposite kinetics in serum in acute pyelonephritis.
IL-19 (show IL19 ELISA Kits) and Ang-2 might be involved in angiogenesis of T2 Diabetes mellitus complications.
Compared with patients with heart failure or those with orthotopic heart transplantation, serum levels and endothelial expression of Ang-2 were higher in LVAD patients. Ang-2 may contribute to arteriovenous malformation formation and subsequent bleeding in LVAD patients.
measurement of serum Ang-2 might be a useful diagnostic marker for solitary pulmonary nodule patients.
A novel role for endothelial cells in therapy resistance and identify endothelial cell/myeloid cell crosstalk is mediated by Ang-2 as a potential resistance mechanism.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (show ANGPT1 ELISA Kits) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (show HIF1A ELISA Kits) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)