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Human Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN624940
Vizio, Biasi, Scirelli, Novarino, Prati, Ciuffreda, Montrucchio, Poli, Bellone: Pancreatic-carcinoma-cell-derived pro-angiogenic factors can induce endothelial-cell differentiation of a subset of circulating CD34+ progenitors. in Journal of translational medicine 2013
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Human Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN414354
Li, Liu, Bin, Wang, Chen, Xiu, Pei, Lai, Chen, Fan, Xie, Tao, Wu: Mutant hypoxia inducible factor-1? improves angiogenesis and tissue perfusion in ischemic rabbit skeletal muscle. in Microvascular research 2011
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Mouse (Murine) Angiopoietin 2 ELISA Kit for Sandwich ELISA - ABIN2683446
Bi, Niu, Ding, Zhang, Yang, Gu: Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism. in Molecular and cellular endocrinology 2016
Shear stress activated Ang-2 via canonical Wnt (show WNT2 ELISA Kits) signaling in vascular endothelial cells, and Wnt (show WNT2 ELISA Kits)-Ang-2 signaling is recapitulated in zebrafish embryos with a translational implication in vascular development and repair.
These results indicate that the Angpt-Tie2 (show TEK ELISA Kits) system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 (show TEK ELISA Kits) agonists could be a therapeutic option for glaucoma.
ANG2 activation of Tie2 (show TEK ELISA Kits) supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 (show TIE1 ELISA Kits) in inflammation leads to ANG2 antagonism of Tie2 (show TEK ELISA Kits) and initiates a positive feedback loop wherein FOXO1 (show FOXO1 ELISA Kits)-driven ANG2 expression promotes vascular remodeling and leakage
A balanced expression of the Ang1 (show ANGPT1 ELISA Kits)/Ang2 system is important for islet physiology. Ang-2 prevents beta-cell mass and islet vascular adaptation in response to HFD feeding with no major influence on glucose homeostasis
These results underscore a pivotal role of Kaposi's sarcoma-associated herpesvirus -induced Ang-2 in KS tumor development by promoting both angiogenesis and inflammation.
NDPKB (show NME1 ELISA Kits) is a protective factor in the retina, which controls Ang2 expression and the hexosamine pathway.
miR (show MLXIP ELISA Kits)-150 is a novel suppressor of Ang2 generation with a key role in resolving vascular injury and reducing mortality resulting from sepsis.
Ang-2 blockage was beneficial as it decreased fatty streak formation and plasma triglyceride levels, but had no adverse effect on pre-existing atherosclerosis in hypercholesterolemic mice.
The results establish Ang2-mediated beta1-integrin activation as a promoter of endothelial destablization, explaining the controversial vascular functions of Ang1 (show ANGPT1 ELISA Kits) and Ang2.
Alprostadil treatment can protect renal function by reducing proteinuria. These effects are mediated, at least in part, through down-regulation of Ang-2 and IL-18 (show IL18 ELISA Kits) expression
ANG2 as the first essential regulator of the functionally important interendothelial cell-cell junctions that form during lymphatic development
High ANG2 expression is associated with angiogenesis and metastasis via IGF1 (show IGF1 ELISA Kits)-IGF1R (show IGF1R ELISA Kits) signaling in epithelial ovarian cancer.
Our novel noninvasive liver fibrosis model, based on serum angiopoietin-2 levels, outperforms other indices and should help substantially in managing CHC (show CLTC ELISA Kits) and monitoring long-term follow-up prognosis
Tie1 (show TIE1 ELISA Kits) directly interacts with Tie2 (show TEK ELISA Kits) to promote ANG (show ANG ELISA Kits)-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 (show TIE1 ELISA Kits) cleavage contributes to loss of ANG2 agonist activity and vascular stability
This systematic review and meta-analysis suggested that serum Ang-2 levels might be a potential predictor for staging, and were associated with prognosis of lung cancer.
Studied angiopoietin-1 (Ang-1 (show ANGPT1 ELISA Kits)) and angiopoietin-2 (Ang-2) within the intervertebral disc (IVD (show IVD ELISA Kits)) and elucidated their functions in the regulation of nucleus pulposus (NP) cells. Found the ratio of Ang-2/Ang-1 (show ANGPT1 ELISA Kits) in tissues from patients increased markedly with increasing age and level of degeneration of the IVD (show IVD ELISA Kits). Results indicate Ang-2 plays a role in suppressing cell adhesion&viability, and promotes the apoptosis of NP cells.
ANG-1 (show ANGPT1 ELISA Kits), ANG-2 and TIE-2 (show TEK ELISA Kits) levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.
Analyses of human gastric cancer tissues showed a strong correlation between DARPP-32 (show PPP1R1B ELISA Kits) and ANGPT2. The role of DARPP-32 (show PPP1R1B ELISA Kits)-STAT3 (show STAT3 ELISA Kits) axis in regulating ANGPT2 in cancer cells to promote angiogenesis and tumorigenesis.
ANGPT2 expression was upregulated in cerebral cavernous malformation lesions.
In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 (show TEK ELISA Kits) expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 (show ANGPT1 ELISA Kits) and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.
expression of angiopoietin 2 in the porcine metanephric kidney was observed in the podocytes of early developing glomeruli, but not in the cells near the glomerular hilus
ANGPT2 remained upregulated during maturation of glomeruli, which may be explained by the continuous growth of the glomeruli, as observed by stereological examination.
forward mandibular positioning enhance the expression of Ang1 (show ANGPT1 ELISA Kits) and Ang2 in condylar cartilage.
These results suggest that circulating Ang-2 participates in the pathogenesis of systemic inflammatory response syndrome after injury connected with early haemodynamic instability.
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha (show HIF1A ELISA Kits) binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene.
Activation of the PI3-K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway could affect the angiogenic process.
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis.
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found.
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
, Angiopoietin-2B (Ang-2B)