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Sp1 (show PSG1 Proteins) transcriptionally regulates BRK1 expression in non-small cell lung cancer cells.
We verified that NRF-1 (show NFE2L1 Proteins) positively regulates FAM134C and ENOX1 (show ENOX1 Proteins), and negatively regulates C3orf10 in human neuroblastoma (show ARHGEF16 Proteins) IMR-32 cells and primary rat cortical neurons.
Data show that Brk1 downregulation results in defective directional migration and invasive growth in renal cell carcinoma cells as well as in other tumor cell types.
Von Hippel-Lindau (VHL) locus deletion of the HSPC300 actin regulator gene greatly lowers risk of clear cell renal cell carcinoma (show MOK Proteins) development in Spanish VHL (show VHL Proteins) syndrome patients studied.
Growing body of evidence suggesting that patients with VHL syndrome caused by large VHL deletions that include C3orf10 may be designated as having a specific subtype (Type 1B) of the disorder.
Data show that genetic ablation of Brk1 results in dramatic defects in embryo compaction and development, suggesting an essential role for this protein in actin dynamics.
BRK1 is required for accumulation of SCAR1 (show WASF1 Proteins) protein in vivo, potentially explaining the apparently essential role of BRK1 in ARP2 (show ACTR2 Proteins)/3 complex function
member of the "distorted group" of trichome morphology mutants and a critical WAVE-complex subunit that selectively stabilizes the Arp2 (show ACTR2 Proteins)/3 activator SCAR2
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity).
probable protein BRICK1
, probable protein brick1
, protein BRICK1
, probable protein BRICK1-B
, BRICK1, SCAR/WAVE actin-nucleating complex subunit, homolog
, haematopoietic stem/progenitor cell protein 300