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Increased expression of the cytoplasmic FMR1-interacting protein 2 (CYFIP2), a known FMRP (show FMR1 Proteins) interactor, is detected in fragile X (show FMR1 Proteins) syndrome.
blood samples of lateral sclerosis patients were found to have significantly different levels of expression of CyFIP2 and RbBP9 (show RBBP9 Proteins) compared to the levels of expression in control subjects.
Studies identify a novel proapoptotic gene target, CYFIP2, which is downregulated by IMP-1, and mediates the regulation of cell survival and K-Ras expression in colon cancer cells.
Protein complexes containing CYFIP (show CYFIP1 Proteins)/Sra (show SRA1 Proteins)/PIR121 coordinate Arf1 (show ARF1 Proteins) and Rac1 signalling during clathrin-AP-1 (show FOSB Proteins)-coated carrier biogenesis at the trans-golgi network.
The CYFIP2 promoter contains a p53 (show TP53 Proteins)-responsive element that confers p53 (show TP53 Proteins) binding as well as transcriptional activation of a heterologous reporter.
cyfip2 is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
Study provides evidence for the role of Cyfip2 in fragile X (show FMR1 Proteins)-like behaviors and regulation of dendritic spines, and for the mGluR (show GRM8 Proteins)-induced regulation of Cyfip2 expression, which could provide new insight into the pathogenesis of the neurological fragile X (show FMR1 Proteins) syndrome phenotypes.
Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity).
cytoplasmic FMR1 interacting protein 2
, cytoplasmic FMR1-interacting protein 2
, p53 inducible protein
, p53-inducible protein 121