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some of the mutations found in EPHB1 may contribute to an increased invasive capacity of cancers.
Association of EPHB1 rs11918092 with symptoms of schizophrenia in Chinese Zhuang and Han populations.
The tumor-suppressor function of EphB1 is clinically relevant across many malignancies, suggesting that EphB1 is an important regulator of common cancer cell transforming pathways.
In medulloblastoma cell lines, EphB1 downregulation or knockdown reduced cell growth, viability, cell-cycle regulator expression, and migration, but increased radiosensitivity and the percentage of cells in G1 phase of the cell cycle.
Our results indicate that EphB1 may be involved in carcinogenesis of renal cell carcinoma (show MOK Proteins)
The genes CD248 (show CD248 Proteins), Ephb1 and P2RY2 (show P2RY2 Proteins) were detected as the top overexpressed in GC biopsies.
The study presents the first structure of the EphB1 tyrosine kinase (show TXK Proteins) domain determined by X-ray crystallography to 2.5A.
EphB1 and Ephrin-B could be regarded as independent good prognostic factors and important biological markers for Squamous cell/adenosquamous carcinoma and adenocarcinoma of gallbladder.
Our data indicate that loss of EphB1 protein is associated with metastasis and poorer survival in patients with serous ovarian cancer
Low EphB1 expression is associated with glioma.
Findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance
During re-epithelialization ephrin-B1 (show EFNB1 Proteins) and its receptor EphB2 (show EPHB2 Proteins) are both upregulated in vivo, just for the duration of repair.
In a genetic medulloblastoma model, EphB1 knockout resulted in a significant delay in tumor recurrence following irradiation compared to EphB1-expressing control tumors.
EphB1 expression is activated in the spinal cord in a bone cancer model.
The studies introduce EphB1 as a new venous-restricted marker in a tissue-specific and time-dependent manner.
Reelin (show RELN Proteins) induces EphB activation.
role of EphB1 receptors signalling in models of inflammatory and neuropathic pain
ephrin B1 (show EFNB1 Proteins) has a role in maintaining the structural integrity of the developing cortex and maintaining apical adhesion of neural progenitors
PI3K and PI3K crosstalk to ERK (show EPHB2 Proteins) signaling contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs.
Data show that EphB1, not Ephb2 (show EPHB2 Proteins), is the preferred receptor of ephrin-B2 (show EFNB2 Proteins) and ephrin-B1 (show EFNB1 Proteins) in mediating axon guidance at the optic chiasm despite the coexpression of EphB2 (show EPHB2 Proteins) in the same ipsilaterally projecting retinal axons.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.
, EPH-like kinase 6
, eph tyrosine kinase 2
, ephrin type-B receptor 1
, neuronally-expressed EPH-related tyrosine kinase
, soluble EPHB1 variant 1
, tyrosine-protein kinase receptor EPH-2
, Elk-like kinase
, Xenopus Elk-like kinase
, ephrin type-B receptor 1-A
, receptor tyrosine kinase
, tyrosine-protein kinase receptor XEK
, ephrin receptor EphB1
, EPH receptor B1
, ephrin receptor EphB1-like
, ephrin type-B receptor 1-like
, ELK-related protein tyrosine kinase
, Eph receptor B2 (ELK-related protein tyrosine kinase)