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Results shows that HER3 mRNA is upregulated in hepatocellular carcinoma associated to chronic HBV infection.
Controlled activation of specific EGFR (show EGFR ELISA Kits), HER2 (show ERBB2 ELISA Kits) and HER3 homodimers and heterodimers caused oesophageal squamous epithelial cell migration and/or invasion.
Results suggest that APIP (show APIP ELISA Kits) stimulates cell proliferation via ERBB3, acting in conjunction with ERBB2 (show ERBB2 ELISA Kits), in gastric cancer cells.
Data show that afatinib resistant clones were selectively killed by knock down of ERBB3 + c-MET + c-KIT (show KIT ELISA Kits), but not by the individual or doublet knock down combinations, and the combination of afatinib with the SRC (show SRC ELISA Kits) family inhibitor dasatinib killed afatinib resistant H1975 cells in a greater than additive fashion.
results suggest that the combination of a histone deacetylase (show HDAC1 ELISA Kits) inhibitor (HDACi) plus an anti-ErbB3 MoAb represents a viable strategy that warrants further evaluation for the treatment of non-small cell lung cancer (NSCLC) patients.
characterized the specific interactome of the epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) family member ERBB2 (show ERBB2 ELISA Kits) when in the form of a homodimer or when in the form of a heterodimer with either EGFR (show EGFR ELISA Kits) or ERBB3.
observations suggest that Rtn4A counteracts the Nrdp1-mediated degradation of ErbB3 by sequestering the ubiquitin ligase into ER tubules.
Engineered multivalency enhanced affibody-mediated HER3 downregulation in multiple cancer cell types.
Both ERBB2 (show ERBB2 ELISA Kits) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (show ERBB2 ELISA Kits) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (show NRG1 ELISA Kits) beta1-induced HIF-1alpha (show HIF1A ELISA Kits) activation in MCF7 cells.
Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Our results support a role for the hepatocellular ERBB (show EGFR ELISA Kits) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (show EGFR ELISA Kits)-ERBB3 DKO models, suggesting that EGFR (show EGFR ELISA Kits)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (show EGFR ELISA Kits) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (show SHH ELISA Kits)) stimulate branching morphogenesis (BrM (show SMARCA2 ELISA Kits)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 ELISA Kits) protein, epidermal growth factor (EGF (show EGF ELISA Kits)) and receptors of the ErbB (show EGFR ELISA Kits) receptors ErbB1 (show EGFR ELISA Kits), ErbB2 (show ERBB2 ELISA Kits) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (show ERBB4 ELISA Kits) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (show AKT1 ELISA Kits) pathway and promoting erbB2 (show ERBB2 ELISA Kits)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (show STAT3 ELISA Kits) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
Data show that Her8a is a negative regulator of neurogenesis and plays an essential role in generating progenitor pools within rhombomeres 2 and 4--a role resembling that of Her3.
Transcription of her3 is repressed rather than activated by Notch (show NOTCH1 ELISA Kits) signalling.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, transcription factor HES-3
, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3