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Widespread expression of ErbB3 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization.
data confirmed that an ErbB3-driven pathway mediates a net positive influence in an in vivo model closely resembling human repair
Both ERBB2 (show ERBB2 ELISA Kits) and ERBB3 are essential for normal proliferation of skin keratinocytes, but in contrast to ERBB3, ERBB2 (show ERBB2 ELISA Kits) is essential for migration of human keratinocytes.
Pretreatment with the soluble ErbB3 N418Q mutant suppressed heregulin (show NRG1 ELISA Kits) beta1-induced HIF-1alpha (show HIF1A ELISA Kits) activation in MCF7 cells.
we show that WASF3 (show WASF3 ELISA Kits) is present in the HER2 (show ERBB2 ELISA Kits) immunocomplex and suppression of WASF3 (show WASF3 ELISA Kits) function leads to suppression of invasion even in the presence of HER2 (show ERBB2 ELISA Kits) expression.The engagement of WASF3 (show WASF3 ELISA Kits) with the HER2 (show ERBB2 ELISA Kits)/HER3 complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (show ERBB2 ELISA Kits)/HER3 activation of JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) signaling.
This study demonstrates novel regulatory circuits involving miR (show MLXIP ELISA Kits)-148a-3p/ERBB3/AKT2 (show AKT2 ELISA Kits)/c-myc (show MYC ELISA Kits) and DNMT1 (show DNMT1 ELISA Kits) that controls bladder cancer progression, which may be useful in the development of more effective therapies against bladder cancer.
HRG (show NRG1 ELISA Kits)/HER2 (show ERBB2 ELISA Kits)/HER3 signaling promotes AhR (show AHR ELISA Kits)-mediated Memo-1 (show MEMO1 ELISA Kits) expression and migration in colorectal cancer
Simultaneous suppression of ErbB (show EGFR ELISA Kits) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (show EGFR ELISA Kits) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.
Targeting both HER2 (show ERBB2 ELISA Kits) and HER3 resulted in an improved treatment effects on HER2 (show ERBB2 ELISA Kits)-positive gastric cancer.
HER3 is frequently overexpressed in high-grade dysplastic lesions of the gastroesophageal junction and may be a marker of invasive progression
the mechanistic regulation and linkage of the ROR1 (show ROR1 ELISA Kits)-HER3 and Hippo-YAP (show YAP1 ELISA Kits) pathway in a cancer-specific context
There were significant differences in human epidermal growth factor receptor (show EGFR ELISA Kits) 2 and human epidermal growth factor receptor (show EGFR ELISA Kits) 3 serum levels between the patients with tissue human epidermal growth factor receptor (show EGFR ELISA Kits) 2-positive and tissue human epidermal growth factor receptor (show EGFR ELISA Kits) 2-negative ( p = 0.0026, p = 0.000011) tumors, but not in the serum levels of human epidermal growth factor receptor (show EGFR ELISA Kits) 4 ( p = 0.054).
Our results support a role for the hepatocellular ERBB (show EGFR ELISA Kits) tyrosine kinases in fibrogenesis. Maximal impact to fibrogenesis occurred in the ERBB3 and EGFR (show EGFR ELISA Kits)-ERBB3 DKO models, suggesting that EGFR (show EGFR ELISA Kits)-ERBB3 heterodimeric signaling in damaged hepatocytes may play a more important role in liver fibrosis than EGFR-EGFR (show EGFR ELISA Kits) homodimeric signaling.
nuc-ErbB3 directly regulates levels of H3K27me3 in Schwann cells
Data indicate that Sonic hedgehog (Shh (show SHH ELISA Kits)) stimulate branching morphogenesis (BrM (show SMARCA2 ELISA Kits)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 ELISA Kits) protein, epidermal growth factor (EGF (show EGF ELISA Kits)) and receptors of the ErbB (show EGFR ELISA Kits) receptors ErbB1 (show EGFR ELISA Kits), ErbB2 (show ERBB2 ELISA Kits) and ErbB3.
ERBB3 is required for wound healing and for the progression of skin tumors in mice.
The expression of ERBB3 in combination with ERBB4 (show ERBB4 ELISA Kits) significantly amplifies proliferation of lymphocytes upon ligand stimulation.
Data indicate that increased expression of erbB3 plays a pivotal role in activating downstream PI-3K/Akt (show AKT1 ELISA Kits) pathway and promoting erbB2 (show ERBB2 ELISA Kits)-driven mammary/breast tumorigenesis.
Suggest that ERBB3 may promote hepatocellular carcinoma through STAT3 (show STAT3 ELISA Kits) activation.
ERBB3 is crucial for the proliferation of Bergmann glia in the developing cerebellum.
ErbB3 plays a key role in migration, as well as in myelination, in mouse Schwann lineage cells.
Knock-down of Erbb3 with siRNA during early differentiation inhibits cardiomyogenesis in embryonic stem cells.
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
, receptor tyrosine kinase ErbB3
, receptor tyrosine-protein kinase erbB-3-like
, proto-oncogene-like protein c-ErbB-3
, receptor tyrosine-protein kinase erbB-3
, tyrosine kinase-type cell surface receptor HER3
, avian erythroblastosis oncogene B 3
, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
, avian erythroblastosis oncogene B 3 receptor
, glial growth factor receptor
, receptor tyrosine kinase