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anti-Human FGF21 Antibodies:
anti-Mouse (Murine) FGF21 Antibodies:
anti-Rat (Rattus) FGF21 Antibodies:
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Human Polyclonal FGF21 Primary Antibody for IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
Human Polyclonal FGF21 Primary Antibody for ELISA, WB - ABIN314287
Inagaki, Dutchak, Zhao, Ding, Gautron, Parameswara, Li, Goetz, Mohammadi, Esser, Elmquist, Gerard, Burgess, Hammer, Mangelsdorf, Kliewer: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. in Cell metabolism 2007
FGF21 appears to act in a paracrine manner to increase glucose uptake under low insulin (show INS Antibodies) conditions, but it does not contribute to the resistance to diet-induced obesity.
Insulin (show INS Antibodies) rather than glucose per se increases total and bioactive FGF21 in the postprandial period in adult humans.
FGF21 has a role in promoting remyelination in the central nervous system
FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity.
serum FGF19 (show FGF19 Antibodies) and FGF21 and hepatic Klotho (show KL Antibodies) expression are inversely associated with hepatic damage in children with NAFLD (show TSC2 Antibodies)
Higher vitamin D status, but not FGF21, was associated with greater postprandial glucose oxidation and improved insulin (show INS Antibodies) sensitivity in metabolic syndrome.
dietary protein dilution promotes improved glucose homeostasis through an select nonessential amino acids insufficiency-induced liver NUPR1 (show NUPR1 Antibodies)/FGF21 axis
In Japanese men, acute endurance exercise lowers serum FGF21 levels 24 h following exercise. The results suggest that acute endurance exercise modulates postprandial FGF21 metabolism regardless of age.
Higher circulating FGF21 levels were associated with a high mortality rate, but not cardiovascular events in patient with end-stage renal disease, suggesting that circulating FGF21 levels serve as a predictive marker for mortality in these subjects.
FGF21 is not critical for bone homeostasis or actions of PPARalpha (show PPARA Antibodies) and PPARgamma (show PPARG Antibodies).
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
mTORC1 mediated many of the beneficial actions of FGF21 in vitro, including UCP1 (show UCP1 Antibodies) and FGF21 induction, increased adiponectin (show ADIPOQ Antibodies) secretion, and enhanced glucose uptake without any adverse effects on insulin (show INS Antibodies) action.
Data suggest that expression of Fgf21 in liver responds acutely to dietary protein intake; low-protein high-carbohydrate diet induces Fgf21 expression; high-protein low-carbohydrate diet reduces Fgf21 expression; Fgf21 expression/secretion in cultured hepatocytes appears to be controlled by glucose but not amino acids.
These findings reveal a previously unappreciated anti-inflammatory role for FGF21 in adipose tissue, but do not support that FGF21 is necessary for exercise-mediated anti-inflammatory effects.
our results reveal that ERRgamma (show ESRRG Antibodies), induced via activation of the hepatic CB1 (show CNR1 Antibodies) receptor, is a regulator of hepatic FGF21 gene expression and secretion.
OPA1 (show MED12 Antibodies) mutant mice are resistant to age- and diet-induced weight gain and insulin (show INS Antibodies) resistance, by mechanisms that involve activation of endoplasmic reticulum stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin (show INS Antibodies) sensitivity.
inhibitor of mTORC1 to control hepatic insulin (show INS Antibodies) action and maintain glucose homeostasis
the acute and chronic effects of FGF21 can be dissociated through adipose-dependent and -independent mechanisms.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21