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Browse our FGFR3 Proteins (FGFR3)

Full name:
Fibroblast Growth Factor Receptor 3 Proteins (FGFR3)
On www.antibodies-online.com are 44 Fibroblast Growth Factor Receptor 3 (FGFR3) Proteins from 15 different suppliers available. Additionally we are shipping FGFR3 Antibodies (176) and FGFR3 Kits (19) and many more products for this protein. A total of 255 FGFR3 products are currently listed.
Synonyms:
ACH, CD333, CEK2, fc27h01, Fgfr-3, FGFR3, Flg-2, FR3, HBGFR, HSFGFR3EX, JTK4, LOC100034114, Mfr3, sam3, wu:fc27h01
list all proteins Gene Name GeneID UniProt
FGFR3 2261 P22607
FGFR3 14184  
Rat FGFR3 FGFR3 84489  

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FGFR3 Proteins (FGFR3) by Origin

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Top referenced FGFR3 Proteins

  1. Mouse (Murine) FGFR3 Protein expressed in Human Cells - ABIN2007272 : Lamy, Gobet, Laurent, Blanchard, Varin, Moulin, Andreou, Frebourg, Pfister: Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. in The Journal of urology 2006 (PubMed)

More Proteins for FGFR3 Interaction Partners

Human Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. Our results indicate that PRMT5 (show PRMT5 Proteins) is a marker of poor prognosis in NPC (show NPC1 Proteins) patients. PRMT5 (show PRMT5 Proteins) promoted the radioresistance of NPC (show NPC1 Proteins) cells via targeting FGFR3, at least partly if not totally.

  2. These data suggest that nuclear translocation of FGFR3 is frequent and carries clinicopathologic as well as prognostic significances in pancreatic cancer

  3. FGFR3 protein is frequently overexpressed in oral and oropharyngeal squamous cell carcinoma.

  4. FGFR3 biology and skeletal disease

  5. analysis of FGFR3 and FGFR4 (show FGFR4 Proteins) gene polymorphisms in breast cancer in Chinese women of Heilongjiang province reveals that SNPs rs1966265 and rs351855 in FGFR4 (show FGFR4 Proteins) , but not rs2234909 and rs3135848 in FGFR3 are associated with breast cancer

  6. The FGFR3, PIK3CA (show PIK3CA Proteins), TERT (show TERT Proteins) mutations, along with aberrant DNA methylation (show HELLS Proteins) patterns, can serve as reliable genetic markers for the diagnosis of urinary bladder cancer. (Review)

  7. The most notable effect of the achondroplasia mutation is increased propensity for FGFR3 dimerization in the absence of ligand.

  8. Findings provide new evidence that PRMT5 (show PRMT5 Proteins) plays an important role in CRC (show CALR Proteins) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E (show EIF4E Proteins) and FGFR3.

  9. Expression of FGF-2 (show FGF2 Proteins), FGFR-2 (show FGFR2 Proteins) and FGFR-3 was upregulated in patients with potentially malignant oral lesions serving as biomarkers of malignant transformation to oral squamous cell carcinoma.

  10. FGF receptor (FGFR) 3 may serve as a promising biomarker for Bladder Cancer. Mutations of this gene are prevalent in BC.

Mouse (Murine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling and upregulation of IHH (show IHH Proteins).

  2. A proliferation-independent and SOX9 (show SOX9 Proteins)-dependent differentiation block is a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders caused by mutations in FGFR3.

  3. This study showed constitutively active form of Fgfr3 to increase FGF signaling.

  4. FGFR3 induces degradation of Bmpr1a (show BMPR1A Proteins) to regulate skeletal development.

  5. microtubule formation is a major downstream effector of Fgf-receptor 3 and this pathway impacts the formation of fluid spaces in the organ of Corti.

  6. FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.

  7. FGFR3 overexpression in lung leads to adenocarcinoma.

  8. our results demonstrate that FGFR1 (show FGFR1 Proteins) is crucial for S115 breast cancer cell proliferation and tumor growth and angiogenesis, whereas FGFR2 (show FGFR2 Proteins) and FGFR3 are less critical for the growth of these cells

  9. Peptide P3 inhibited tyrosine kinase (show TYRO3 Proteins) activity of FGFR3 and the ERK/MAPK (show MAPK1 Proteins) pathway.

  10. dysregulation of Sox9 (show SOX9 Proteins) and beta-catenin (show CTNNB1 Proteins) levels and activity in growth plate chondrocytes is an important underlying mechanism in skeletal diseases caused by mutations in FGFR3

Zebrafish Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

Cow (Bovine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.

  2. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  3. chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene

FGFR3 Protein Profile

Protein Summary

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Alternative names and synonyms associated with FGFR3

  • fibroblast growth factor receptor 3 (FGFR3)
  • fibroblast growth factor receptor 3 (LOC100034114)
  • FGF receptor 3 (fgfr3)
  • fibroblast growth factor receptor 3 (Fgfr3)
  • fibroblast growth factor receptor 3 (fgfr3)
  • ACH protein
  • CD333 protein
  • CEK2 protein
  • fc27h01 protein
  • Fgfr-3 protein
  • FGFR3 protein
  • Flg-2 protein
  • FR3 protein
  • HBGFR protein
  • HSFGFR3EX protein
  • JTK4 protein
  • LOC100034114 protein
  • Mfr3 protein
  • sam3 protein
  • wu:fc27h01 protein

Protein level used designations for FGFR3

fibroblast growth factor receptor 3 , FGFR-3 , fibroblast growth factor receptor 3 variant 4 , hydroxyaryl-protein kinase , tyrosine kinase JTK4 , heparin-binding growth factor receptor , fibroblast growth factor receptor 3-IIIc , tyrosine kinase (cek2) , tyrosine kinase receptor CEK2 , fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

GENE ID SPECIES
461067 Pan troglodytes
554324 Ovis aries
712829 Macaca mulatta
100034114 Equus caballus
100141386 Felis catus
399347 Xenopus laevis
2261 Homo sapiens
14184 Mus musculus
84489 Rattus norvegicus
396515 Gallus gallus
100732948 Cavia porcellus
58129 Danio rerio
488808 Canis lupus familiaris
281769 Bos taurus
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