Browse our FGFR3 Proteins (FGFR3)

Full name:
Fibroblast Growth Factor Receptor 3 Proteins (FGFR3)
On www.antibodies-online.com are 56 Fibroblast Growth Factor Receptor 3 (FGFR3) Proteins from 15 different suppliers available. Additionally we are shipping FGFR3 Antibodies (208) and FGFR3 Kits (26) and many more products for this protein. A total of 308 FGFR3 products are currently listed.
Synonyms:
ACH, CD333, CEK2, fc27h01, Fgfr-3, FGFR3, Flg-2, FR3, HBGFR, HSFGFR3EX, JTK4, LOC100034114, Mfr3, sam3, wu:fc27h01
list all proteins Gene Name GeneID UniProt
FGFR3 2261 P22607
FGFR3 14184  
Rat FGFR3 FGFR3 84489  

Show all synonyms

FGFR3 Proteins (FGFR3) by Origin

Select your origin of interest

Top referenced FGFR3 Proteins

  1. Mouse (Murine) FGFR3 Protein expressed in Human Cells - ABIN2007272 : Lamy, Gobet, Laurent, Blanchard, Varin, Moulin, Andreou, Frebourg, Pfister: Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. in The Journal of urology 2006 (PubMed)

More Proteins for FGFR3 Interaction Partners

Human Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. Liposarcoma patients harboring FGFR1 (show FGFR1 Proteins)/3 mutations experienced reduced overall survival.

  2. High FGFR3 expression is associated with bladder cancer.

  3. Study provides evidence of the significant oncogenic potential of the FGFR3-TACC3 (show TACC3 Proteins) fusion protein. The presence of the TACC coiled-coil domain leads to increased and altered levels of FGFR3 activation, fusion protein phosphorylation, downstream signaling, cellular transformation, proliferation, and viability.

  4. we show that low dose of NVP-BGJ398 improves in vivo condyle growth and corrects dysmorphologies in Fgfr3(Y367C/+) mice, suggesting that postnatal treatment with NVP-BGJ398 mice might offer a new therapeutic strategy to improve mandible anomalies in achondroplasia (ACH), and others FGFR3-related disorders.

  5. FGFR3 mRNA missplicing in hepatocellular carcinoma (HCC (show FAM126A Proteins)), contributes significantly to its malignant character.

  6. Mutations in FGFR3 gene is associated with tubular adenomas.

  7. High FGFR3 expression is associated with multiple myeloma.

  8. FGFR3 was predominantly mutated in infiltrative hepatocellular carcinoma (HCC (show FAM126A Proteins)) compared to nodular HCC (show FAM126A Proteins). FGFR3 protein expression was higher in mutated infiltrative HCC (show FAM126A Proteins) compared to non-mutated infiltrative HCC (show FAM126A Proteins) and nodular HCC (show FAM126A Proteins). FGFR3 may be a candidate oncogene (show RAB1A Proteins) in tumor progression.

  9. Our findings show that grade heterogeneity in urothelial carcinoma is characterized by increased MIB-1 labelling, and particularly in the FGFR3 mutant pathway, with homozygous deletions of CDKN2A in low- and high-grade areas

  10. We argue that routine use of molecular genomic tumour analysis in urothelial carcinoma may inform selection of patients for appropriate trials and we further investigate the potential of FGFR3 as a meaningful clinical target for this difficult disease

Mouse (Murine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. NVP-BGJ398 inhibited FGFR3 downstream signaling pathways, including MAPK (show MAPK1 Proteins), SOX9 (show SOX9 Proteins), STAT1 (show STAT1 Proteins), and PLCgamma, in the growth plates of Fgfr3Y367C/+ mice and in cultured chondrocyte models of Achondroplasia.

  2. data suggest that FGF2 (show FGF2 Proteins) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 Proteins), FGFR2 (show FGFR2 Proteins), and FGFR3.

  3. we show that low dose of NVP-BGJ398 improves in vivo condyle growth and corrects dysmorphologies in Fgfr3(Y367C/+) mice, suggesting that postnatal treatment with NVP-BGJ398 mice might offer a new therapeutic strategy to improve mandible anomalies in achondroplasia (ACH), and others FGFR3-related disorders.

  4. Conditional Fgfr3 deletion in mice aggravated destabilization of medial meniscus (DMM (show COL2A1 Proteins))-induced cartilage degeneration. FGFR-3 activation attenuated cartilage degeneration induced by DMM (show COL2A1 Proteins) surgery and age.

  5. Using a mouse model of Thanatophoric Dysplasia Type II (TDII) we show that both HDAC6 (show HDAC6 Proteins) deletion and treatment with the small molecule HDAC6 (show HDAC6 Proteins) inhibitor tubacin reduced FGFR3 accumulation in the growth plate and improved endochondral bone growth

  6. This study reveals that chondrocyte FGFR3 is involved in the regulation of bone formation and bone remodeling by a paracrine mechanism.

  7. Results show that Fgfr3-deficient mice exhibit progressive osteoarthritis-like defects in temporomandibular Joint (TMJ) changes, indicating that FGFR3 signaling is critically involved in the maintenance of the structure integrity and function of TMJ articular cartilage during adult stage.

  8. loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling and upregulation of IHH (show IHH Proteins).

  9. A proliferation-independent and SOX9 (show SOX9 Proteins)-dependent differentiation block is a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders caused by mutations in FGFR3.

  10. This study showed constitutively active form of Fgfr3 to increase FGF signaling.

Zebrafish Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

Cow (Bovine) Fibroblast Growth Factor Receptor 3 (FGFR3) interaction partners

  1. The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.

  2. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

  3. chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene

FGFR3 Protein Profile

Protein Summary

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Alternative names and synonyms associated with FGFR3

  • fibroblast growth factor receptor 3 (FGFR3)
  • fibroblast growth factor receptor 3 (LOC100034114)
  • FGF receptor 3 (fgfr3)
  • fibroblast growth factor receptor 3 (Fgfr3)
  • fibroblast growth factor receptor 3 (fgfr3)
  • ACH protein
  • CD333 protein
  • CEK2 protein
  • fc27h01 protein
  • Fgfr-3 protein
  • FGFR3 protein
  • Flg-2 protein
  • FR3 protein
  • HBGFR protein
  • HSFGFR3EX protein
  • JTK4 protein
  • LOC100034114 protein
  • Mfr3 protein
  • sam3 protein
  • wu:fc27h01 protein

Protein level used designations for FGFR3

fibroblast growth factor receptor 3 , FGFR-3 , fibroblast growth factor receptor 3 variant 4 , hydroxyaryl-protein kinase , tyrosine kinase JTK4 , heparin-binding growth factor receptor , fibroblast growth factor receptor 3-IIIc , tyrosine kinase (cek2) , tyrosine kinase receptor CEK2 , fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)

GENE ID SPECIES
461067 Pan troglodytes
554324 Ovis aries
712829 Macaca mulatta
100034114 Equus caballus
100141386 Felis catus
399347 Xenopus laevis
2261 Homo sapiens
14184 Mus musculus
84489 Rattus norvegicus
396515 Gallus gallus
100732948 Cavia porcellus
58129 Danio rerio
488808 Canis lupus familiaris
281769 Bos taurus
Selected quality suppliers for FGFR3 Proteins (FGFR3)
Did you look for something else?