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Mouse (Murine) FGFR3 Protein expressed in Human Cells - ABIN2007272
Lamy, Gobet, Laurent, Blanchard, Varin, Moulin, Andreou, Frebourg, Pfister: Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. in The Journal of urology 2006
FGFR3 gene mutations are associated with Urinary Bladder Cancer.
we identified a novel FGFR3 mutation, p.Ser348Cys, in a patient with achondroplasia. A number of different FGFR3 mutations can cause achondroplasia; therefore, if the common p.Gly380Arg mutation is not found, complete analysis of FGFR3 is indicated in patients with achondroplasia
FGFR3 promotes angiogenesis-dependent metastasis of hepatocellular carcinoma via facilitating MCP-1 (show CCL2 Proteins)-mediated vascular formation.
The expression of FGFR3-AS1 (show PTGDR Proteins) and FGFR3 is positively correlated in osteosarcoma tissues
Combined urinary FGFR3/Cyclin D3 (show CCND3 Proteins) expression shows improved detection rates for bladder cancer recurrence with high specificity and sensitivity.
Our results indicate that PRMT5 (show PRMT5 Proteins) is a marker of poor prognosis in NPC (show NPC1 Proteins) patients. PRMT5 (show PRMT5 Proteins) promoted the radioresistance of NPC (show NPC1 Proteins) cells via targeting FGFR3, at least partly if not totally.
These data suggest that nuclear translocation of FGFR3 is frequent and carries clinicopathologic as well as prognostic significances in pancreatic cancer
FGFR3 protein is frequently overexpressed in oral and oropharyngeal squamous cell carcinoma.
FGFR3 biology and skeletal disease
analysis of FGFR3 and FGFR4 (show FGFR4 Proteins) gene polymorphisms in breast cancer in Chinese women of Heilongjiang province reveals that SNPs rs1966265 and rs351855 in FGFR4 (show FGFR4 Proteins) , but not rs2234909 and rs3135848 in FGFR3 are associated with breast cancer
loss of Fgfr3 function leads to the formation of chondroma-like lesions via downregulation of MEK (show MDK Proteins)/ERK (show EPHB2 Proteins) signaling and upregulation of IHH (show IHH Proteins).
A proliferation-independent and SOX9 (show SOX9 Proteins)-dependent differentiation block is a key driving mechanism responsible for poor endochondral bone growth in achondroplasia disorders caused by mutations in FGFR3.
This study showed constitutively active form of Fgfr3 to increase FGF signaling.
FGFR3 induces degradation of Bmpr1a (show BMPR1A Proteins) to regulate skeletal development.
microtubule formation is a major downstream effector of Fgf-receptor 3 and this pathway impacts the formation of fluid spaces in the organ of Corti.
FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.
FGFR3 overexpression in lung leads to adenocarcinoma.
our results demonstrate that FGFR1 (show FGFR1 Proteins) is crucial for S115 breast cancer cell proliferation and tumor growth and angiogenesis, whereas FGFR2 (show FGFR2 Proteins) and FGFR3 are less critical for the growth of these cells
Peptide P3 inhibited tyrosine kinase (show TYRO3 Proteins) activity of FGFR3 and the ERK/MAPK (show MAPK1 Proteins) pathway.
dysregulation of Sox9 (show SOX9 Proteins) and beta-catenin (show CTNNB1 Proteins) levels and activity in growth plate chondrocytes is an important underlying mechanism in skeletal diseases caused by mutations in FGFR3
The ectodomain of FGFR3 is proteolytically cleaved in response to ligand-induced receptor activation by FGF1, but unlike most regulated intramembrane proteolysis target proteins, it requires endocytosis and does not involve a metalloproteinase.
Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
chondrodysplastic dwarfism in Japanese brown cattle is not caused by mutation in the FGFR3 gene
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.
fibroblast growth factor receptor 3
, fibroblast growth factor receptor 3 variant 4
, hydroxyaryl-protein kinase
, tyrosine kinase JTK4
, heparin-binding growth factor receptor
, fibroblast growth factor receptor 3-IIIc
, tyrosine kinase (cek2)
, tyrosine kinase receptor CEK2
, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)