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Vegfd can compensate for loss of Vegfc (show VEGFC ELISA Kits) in zebrafish facial lymphatic sprouting.
VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.
Our studies therefore identified the first non-mammalian VEGF-D and established its in vivo role for vascular system development during vertebrate embryogenesis and provided an alternative animal model to further reveal functions of VEGF-D.
These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A (show VEGFA ELISA Kits) and VEGF-D play critical roles in this process.
Results provided evidence that IL-7 (show IL7 ELISA Kits)/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun (show JUN ELISA Kits) pathway in lung cancer.
Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C (show VEGFC ELISA Kits) or VEGF-D.
Neutrophils contribute to lymphangiogenesis primarily by modulating VEGF-A (show VEGFA ELISA Kits) bioavailability and bioactivity and, to a lesser extent, secreting VEGF-D. Neutrophils increased VEGF-A (show VEGFA ELISA Kits) bioavailability and bioactivity via the secretion of MMP9 (show MMP9 ELISA Kits) and heparanase (show HPSE ELISA Kits).
Vegf-d deficiency alters the caliber of initial lymphatics in the dermis leading to reduced functional capacity.
Vascular endothelial growth factor-C (show VEGFC ELISA Kits) and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction.
VEGF-D has a role in progestin-induced break-through bleeding in thin-walled blood and lymphatic endometrial vessels
nuclear calcium-VEGFD signaling mediates the effect of neuronal activity on the maintenance of dendritic arbors in the adult hippocampus and is required for cognitive functioning.
Data show that that OUBC induces profound lymphangiogenesis in the tumor and SLN (show SLN ELISA Kits) and substantial lymphatic metastasis to SLN (show SLN ELISA Kits) through VEGF-C (show VEGFC ELISA Kits)/D-VEGFR-3 (show FLT4 ELISA Kits) signaling pathway.
VEGF-D over-expression has differential effects on the uterine vasculature. These effects may facilitate VEGF-D's ability to promote endometrial cancer metastasis and disease progression.
Data indicate that vascular endothelial growth factor D (VEGF-D) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3 (show FLT4 ELISA Kits)) may help to determine the prognosis and management of colorectal cancer (CRC (show CALR ELISA Kits)).
Taken together, our data suggest that TNF-alpha (show TNF ELISA Kits) can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2 (show MAPK1/3 ELISA Kits)/AP-1 (show FOSB ELISA Kits)/VEGF-D pathway.
VEGF-D may play an important role in the process of lymphatic metastasis of epithelial ovarian cancer
CCL21 (show CCL21 ELISA Kits)/CCR7 (show CCR7 ELISA Kits) induce VEGF-D up-regulation and promote lymphangiogenesis via ERK (show EPHB2 ELISA Kits)/Akt (show AKT1 ELISA Kits) pathway in lung cancer.
The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC ELISA Kits) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 ELISA Kits)-3 (VEGFR-3 (show FLT4 ELISA Kits)).
Study demonstrated that VEGF-D upregulates myofibroblast proliferation, migration, and collagen synthesis through activation of VEGF pathway.
MTA1 (show MTA1 ELISA Kits) is up-regulated in CRC (show CALR ELISA Kits); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC ELISA Kits), VEGFD and VEGFR3 (show FLT4 ELISA Kits)
VEGF-C (show VEGFC ELISA Kits)/D score correlated neither with periphery Lymphatic vessel density (LVD) nor with LVD in the tumor center
study suggests that both VEGF-C (show VEGFC ELISA Kits) and VEGF-D in tumor cells promote lymph node metastasis
A positive association for VEGF-D and an inverse association for MMP-2 (show MMP2 ELISA Kits) were observed in patients with positive lymph node status at the time of radical cystectomy in urothelial carcinoma of the bladder.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.
c-fos induced growth factor (vascular endothelial growth factor D)
, vascular endothelial growth factor D
, vascular enthelial growth factor D
, vegf d
, Vascular endothelial growth factor D
, c-fos-induced growth factor