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Browse our FIGF Proteins (Figf)

Full name:
C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) Proteins (Figf)
On are 27 C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Proteins from 12 different suppliers available. Additionally we are shipping FIGF Antibodies (132) and FIGF Kits (48) and many more products for this protein. A total of 214 FIGF products are currently listed.
AI325264, FIGF, Vegf-d, Vegfd
list all proteins Gene Name GeneID UniProt
Figf 14205 P97946
Figf 360457 O35251
Figf 2277 O43915

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FIGF Proteins (Figf) by Origin

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Top referenced FIGF Proteins

  1. Rat (Rattus) FIGF Protein expressed in Human Cells - ABIN2009160 : Stacker, Stenvers, Caesar, Vitali, Domagala, Nice, Roufail, Simpson, Moritz, Karpanen, Alitalo, Achen: Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 references for ABIN2009160

  2. Human FIGF Protein expressed in Human Cells - ABIN2003050 : Baldwin, Catimel, Nice, Roufail, Hall, Stenvers, Karkkainen, Alitalo, Stacker, Achen: The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN2003050

  3. Mouse (Murine) FIGF Protein expressed in Human Cells - ABIN2007419 : McColl, Baldwin, Roufail, Freeman, Moritz, Simpson, Alitalo, Stacker, Achen: Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. in The Journal of experimental medicine 2003 (PubMed)
    Show all 4 references for ABIN2007419

  4. Mouse (Murine) FIGF Protein expressed in Human Cells - ABIN2007415 : Roy, Bhardwaj, Ylä-Herttuala: Biology of vascular endothelial growth factors. in FEBS letters 2006 (PubMed)
    Show all 4 references for ABIN2007415

  5. Human FIGF Protein expressed in Escherichia coli (E. coli) - ABIN1047904 : Yamada, Nezu, Shimane, Hirata: Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. in Genomics 1997 (PubMed)
    Show all 3 references for ABIN1047904

  6. Human FIGF Protein expressed in HEK-293 Cells - ABIN2181913 : Leppänen, Jeltsch, Anisimov, Tvorogov, Aho, Kalkkinen, Toivanen, Ylä-Herttuala, Ballmer-Hofer, Alitalo: Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. in Blood 2011 (PubMed)

More Proteins for FIGF Interaction Partners

Zebrafish C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. Vegfd can compensate for loss of Vegfc (show VEGFC Proteins) in zebrafish facial lymphatic sprouting.

  2. VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.

  3. Our studies therefore identified the first non-mammalian VEGF-D and established its in vivo role for vascular system development during vertebrate embryogenesis and provided an alternative animal model to further reveal functions of VEGF-D.

Mouse (Murine) C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A (show VEGFA Proteins) and VEGF-D play critical roles in this process.

  2. Results provided evidence that IL-7 (show IL7 Proteins)/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun (show JUN Proteins) pathway in lung cancer.

  3. Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C (show VEGFC Proteins) or VEGF-D.

  4. Neutrophils contribute to lymphangiogenesis primarily by modulating VEGF-A (show VEGFA Proteins) bioavailability and bioactivity and, to a lesser extent, secreting VEGF-D. Neutrophils increased VEGF-A (show VEGFA Proteins) bioavailability and bioactivity via the secretion of MMP9 (show MMP9 Proteins) and heparanase (show HPSE Proteins).

  5. Vegf-d deficiency alters the caliber of initial lymphatics in the dermis leading to reduced functional capacity.

  6. Vascular endothelial growth factor-C (show VEGFC Proteins) and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction.

  7. VEGF-D has a role in progestin-induced break-through bleeding in thin-walled blood and lymphatic endometrial vessels

  8. nuclear calcium-VEGFD signaling mediates the effect of neuronal activity on the maintenance of dendritic arbors in the adult hippocampus and is required for cognitive functioning.

  9. Data show that that OUBC induces profound lymphangiogenesis in the tumor and SLN and substantial lymphatic metastasis to SLN through VEGF-C (show VEGFC Proteins)/D-VEGFR-3 (show FLT4 Proteins) signaling pathway.

  10. VEGF-D over-expression has differential effects on the uterine vasculature. These effects may facilitate VEGF-D's ability to promote endometrial cancer metastasis and disease progression.

Human C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC Proteins) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 Proteins)-3 (VEGFR-3 (show FLT4 Proteins)).

  2. Study demonstrated that VEGF-D upregulates myofibroblast proliferation, migration, and collagen synthesis through activation of VEGF pathway.

  3. MTA1 (show MTA1 Proteins) is up-regulated in CRC (show CALR Proteins); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC Proteins), VEGFD and VEGFR3 (show FLT4 Proteins)

  4. VEGF-C (show VEGFC Proteins)/D score correlated neither with periphery Lymphatic vessel density (LVD) nor with LVD in the tumor center

  5. study suggests that both VEGF-C (show VEGFC Proteins) and VEGF-D in tumor cells promote lymph node metastasis

  6. A positive association for VEGF-D and an inverse association for MMP-2 (show MMP2 Proteins) were observed in patients with positive lymph node status at the time of radical cystectomy in urothelial carcinoma of the bladder.

  7. These findings suggest that IL-8 (show IL8 Proteins) may be a potent inducer of LECs, although this effect does not appear to involve the VEGF-C (show VEGFC Proteins)/VEGF-D and VEGFR-3 (show FLT4 Proteins) signaling pathway.

  8. fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.

  9. Among VEGF (show VEGFA Proteins) homologs, MMPE from various kinds of tumor origin, VEGF-D showed 92.6% rate of positive expression. ICC stain of VEGF-D is a useful marker in the aid of MMPE diagnosis.

  10. VEGF-D is involved in the development of lymphangiogenesis in peritoneal dialysis patients.

FIGF (Figf) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.

Alternative names and synonyms associated with FIGF (Figf)

  • c-fos induced growth factor (vascular endothelial growth factor D) (FIGF)
  • c-fos induced growth factor (figf)
  • c-fos induced growth factor (vascular endothelial growth factor D) (figf)
  • Vascular endothelial growth factor D (vegfd)
  • c-fos induced growth factor (Figf)
  • AI325264 protein
  • FIGF protein
  • Vegf-d protein
  • Vegfd protein

Protein level used designations for Figf

c-fos induced growth factor (vascular endothelial growth factor D) , vascular endothelial growth factor D , vascular enthelial growth factor D , vegf d , vegf-d , Vascular endothelial growth factor D , c-fos-induced growth factor

712654 Macaca mulatta
100050877 Equus caballus
100601827 Nomascus leucogenys
678512 Danio rerio
100144690 Xenopus (Silurana) tropicalis
100158352 Xenopus laevis
465508 Pan troglodytes
493703 Felis catus
100195607 Salmo salar
14205 Mus musculus
360457 Rattus norvegicus
2277 Homo sapiens
286799 Bos taurus
100338090 Oryctolagus cuniculus
100155670 Sus scrofa
491749 Canis lupus familiaris
395255 Gallus gallus
101102873 Ovis aries
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