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Browse our FIGF Proteins (Figf)

Full name:
C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) Proteins (Figf)
On www.antibodies-online.com are 35 C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) Proteins from 13 different suppliers available. Additionally we are shipping FIGF Antibodies (137) and FIGF Kits (53) and many more products for this protein. A total of 235 FIGF products are currently listed.
Synonyms:
AI325264, FIGF, Vegf-d, Vegfd
list all proteins Gene Name GeneID UniProt
Figf 14205 P97946
Figf 360457 O35251
Figf 2277 O43915

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Top referenced FIGF Proteins

  1. Human FIGF Protein expressed in Human Cells - ABIN2003050 : Stacker, Stenvers, Caesar, Vitali, Domagala, Nice, Roufail, Simpson, Moritz, Karpanen, Alitalo, Achen: Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. in The Journal of biological chemistry 1999 (PubMed)
    Show all 4 references for ABIN2003050

  2. Mouse (Murine) FIGF Protein expressed in Human Cells - ABIN2007419 : Baldwin, Catimel, Nice, Roufail, Hall, Stenvers, Karkkainen, Alitalo, Stacker, Achen: The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN2007419

  3. Rat (Rattus) FIGF Protein expressed in Human Cells - ABIN2009160 : McColl, Baldwin, Roufail, Freeman, Moritz, Simpson, Alitalo, Stacker, Achen: Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. in The Journal of experimental medicine 2003 (PubMed)
    Show all 4 references for ABIN2009160

  4. Human FIGF Protein expressed in Escherichia coli (E. coli) - ABIN1047904 : Yamada, Nezu, Shimane, Hirata: Molecular cloning of a novel vascular endothelial growth factor, VEGF-D. in Genomics 1997 (PubMed)
    Show all 3 references for ABIN1047904

  5. Human FIGF Protein expressed in HEK-293 Cells - ABIN2181913 : Leppänen, Jeltsch, Anisimov, Tvorogov, Aho, Kalkkinen, Toivanen, Ylä-Herttuala, Ballmer-Hofer, Alitalo: Structural determinants of vascular endothelial growth factor-D receptor binding and specificity. in Blood 2011 (PubMed)

More Proteins for FIGF Interaction Partners

Zebrafish C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. Vegfd can compensate for loss of Vegfc (show VEGFC Proteins) in zebrafish facial lymphatic sprouting.

  2. VEGFD-mediated pathologies include or involve an underlying dysregulation of SOXF-mediated transcriptional networks.

  3. Our studies therefore identified the first non-mammalian VEGF-D and established its in vivo role for vascular system development during vertebrate embryogenesis and provided an alternative animal model to further reveal functions of VEGF-D.

Mouse (Murine) C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. Overexpression of VEGFD causes lymphatic hyperplasia in lung, kidney, and brown adipose tissue. Overexpression of VEGFD in white adipose tissue causes a de novo lymphatic network.

  2. Vegf-d promotes oedema in response to hyperoxia in mice and support the hypothesis that VEGF-D signalling promotes vascular leak in human hyperoxic acute lung injury (HALI).

  3. VEGF-D may be beneficial in early-stage tumors since it suppresses the pro-tumorigenic inflammation, while at later stages VEGF-D-induced tumor lymphatics provide a route for metastasis.

  4. These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A (show VEGFA Proteins) and VEGF-D play critical roles in this process.

  5. Results provided evidence that IL-7 (show IL7 Proteins)/IL-7R induce VEGF-D upregulation and promote lymphangiogenesis via c-Fos/c-Jun (show JUN Proteins) pathway in lung cancer.

  6. Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C (show VEGFC Proteins) or VEGF-D.

  7. Neutrophils contribute to lymphangiogenesis primarily by modulating VEGF-A (show VEGFA Proteins) bioavailability and bioactivity and, to a lesser extent, secreting VEGF-D. Neutrophils increased VEGF-A (show VEGFA Proteins) bioavailability and bioactivity via the secretion of MMP9 (show MMP9 Proteins) and heparanase (show HPSE Proteins).

  8. Vegf-d deficiency alters the caliber of initial lymphatics in the dermis leading to reduced functional capacity.

  9. Vascular endothelial growth factor-C (show VEGFC Proteins) and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction.

  10. VEGF-D has a role in progestin-induced break-through bleeding in thin-walled blood and lymphatic endometrial vessels

Human C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) interaction partners

  1. VEGF-D and its receptors were co-localized on blood vessels in clinical samples of human lungs exposed to hyperoxia; hence, VEGF-D may act directly on blood vessels to promote fluid leak.

  2. VEGF-D-enhanced metastasis was evidently reversed by MP. MP significantly reduced the invasion of VEGFD-SK cells, tumor volume, lymphatic metastasis rates and lymphatic vessel density compared with control groups

  3. Sulf2 (show SULF2 Proteins) facilitated lymphangiogenesis in breast cancer cells by regulating VEGF-D and that the AKT1related signaling pathway was involved.

  4. Data indicate that vascular endothelial growth factor D (VEGF-D) was the best indicator of metastasis and vascular endothelial growth factors and receptor-3 (VEGFR-3 (show FLT4 Proteins)) may help to determine the prognosis and management of colorectal cancer (CRC (show CALR Proteins)).

  5. Taken together, our data suggest that TNF-alpha (show TNF Proteins) can promote lymphangiogenesis and lymphatic metastasis of GBC through the ERK1/2/AP-1 (show FOSB Proteins)/VEGF-D pathway.

  6. VEGF-D may play an important role in the process of lymphatic metastasis of epithelial ovarian cancer

  7. CCL21 (show CCL21 Proteins)/CCR7 (show CCR7 Proteins) induce VEGF-D up-regulation and promote lymphangiogenesis via ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins) pathway in lung cancer.

  8. The most extensively accepted signaling pathways promoting lymphangiogenesis in tumors include the secreted lymphangiogenic proteins: VEGF-C (show VEGFC Proteins) and VEGF-D, and their cognate receptor on lymphatic endothelium VEGF receptor (show FLT1 Proteins)-3 (VEGFR-3 (show FLT4 Proteins)).

  9. Study demonstrated that VEGF-D upregulates myofibroblast proliferation, migration, and collagen synthesis through activation of VEGF pathway.

  10. MTA1 (show MTA1 Proteins) is up-regulated in CRC (show CALR Proteins); its expression is inversely associated with lymphatic metastases and the expression of VEGFC (show VEGFC Proteins), VEGFD and VEGFR3 (show FLT4 Proteins)

FIGF (Figf) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.

Alternative names and synonyms associated with FIGF (Figf)

  • c-fos induced growth factor (vascular endothelial growth factor D) (FIGF)
  • c-fos induced growth factor (figf)
  • c-fos induced growth factor (vascular endothelial growth factor D) (figf)
  • Vascular endothelial growth factor D (vegfd)
  • c-fos induced growth factor (Figf)
  • AI325264 protein
  • FIGF protein
  • Vegf-d protein
  • Vegfd protein

Protein level used designations for Figf

c-fos induced growth factor (vascular endothelial growth factor D) , vascular endothelial growth factor D , vascular enthelial growth factor D , vegf d , vegf-d , Vascular endothelial growth factor D , c-fos-induced growth factor

GENE ID SPECIES
712654 Macaca mulatta
100050877 Equus caballus
100601827 Nomascus leucogenys
678512 Danio rerio
100144690 Xenopus (Silurana) tropicalis
100158352 Xenopus laevis
465508 Pan troglodytes
493703 Felis catus
100195607 Salmo salar
14205 Mus musculus
360457 Rattus norvegicus
2277 Homo sapiens
286799 Bos taurus
100338090 Oryctolagus cuniculus
100155670 Sus scrofa
491749 Canis lupus familiaris
395255 Gallus gallus
101102873 Ovis aries
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