Browse our HGF Proteins (HGF)

Full name:
Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) Proteins (HGF)
On are 82 Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) Proteins from 18 different suppliers available. Additionally we are shipping HGF Antibodies (261) and HGF Kits (121) and many more products for this protein. A total of 481 HGF products are currently listed.
AI838057, c-Met, C230052L06Rik, DFNB39, F-TCF, HGF, HGF/SF, HGFB, HGFR, HPTA, NK1, NK2, Par4, SF, SF/HGF
list all proteins Gene Name GeneID UniProt
HGF 15234 Q08048
HGF 24446 P17945
HGF 3082 P14210

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HGF Proteins (HGF) by Origin

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Top referenced HGF Proteins

  1. Human HGF Protein expressed in Insect Cells - ABIN2666489 : DAngelo, Bernasconi, Schäfer, Moyat, Michetti, Maillard, Velin: Macrophages promote epithelial repair through hepatocyte growth factor secretion. in Clinical and experimental immunology 2013 (PubMed)
    Show all 6 references for 2666489

  2. Rat (Rattus) HGF Protein expressed in Human Cells - ABIN2009606 : Comoglio: Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. in EXS 1993 (PubMed)
    Show all 4 references for 2009606

  3. Dog (Canine) HGF Protein expressed in Human Cells - ABIN2008912 : Brown, Gydesen, Johannsen, Gade, Skibinski, Chakrabarti, Brun, Spillantini, Yancopoulou, Thusgaard, Sorensen, Fisher, Collinge: Frontotemporal dementia linked to chromosome 3. in Dementia and geriatric cognitive disorders 2004 (PubMed)
    Show all 3 references for 2008912

  4. Mouse (Murine) HGF Protein expressed in Human Cells - ABIN2007211 : Kemp, Mulloy, Gherardi: Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. in Biochemical Society transactions 2006 (PubMed)
    Show all 3 references for 2007211

  5. Rat (Rattus) HGF Protein expressed in Escherichia coli (E. coli) - ABIN1047160 : Okajima, Miyazawa, Kitamura: Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury. in European journal of biochemistry / FEBS 1990 (PubMed)
    Show all 2 references for 1047160

  6. Human HGF Protein expressed in Insect Cells - ABIN1589618 : Rezzola, Dal Monte, Belleri, Bugatti, Chiodelli, Corsini, Cammalleri, Cancarini, Morbidelli, Oreste, Bagnoli, Semeraro, Presta: Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy. in Diabetes 2015 (PubMed)
    Show all 2 references for 1589618

  7. Human HGF Protein expressed in HEK-293 Cells - ABIN2722630 : Ueda, Ito, Shiraishi, Taniguchi, Kayukawa, Nakanishi, Nakamura, Naya, Hongo, Kamoi, Okihara, Kawauchi, Miki: PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model. in Biochimica et biophysica acta 2015 (PubMed)

More Proteins for HGF Interaction Partners

Mouse (Murine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) interaction partners

  1. a c-Met/ETS-1 (show ETS1 Proteins)/matrix metalloproteinase-14 (MMP-14 (show MMP14 Proteins)) axis that controls VE-cadherin (show CDH5 Proteins) degradation, endothelial mesenchymal transition, and vascular abnormality.

  2. Our results show that BMF (show BMF Proteins)-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis.

  3. We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva

  4. c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.

  5. this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis

  6. In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS (show RALGDS Proteins) at Y752 in its RBD (show CACNA1D Proteins), which blocks the binding of Ras to RalGDS (show RALGDS Proteins).

  7. HGF displays an antioxidant response by inducing the glutathione-related protection system.

  8. this study revealed that HB-EGF (show HBEGF Proteins) as well as HGF inhibited BDL-induced cholestatic liver injury by predominantly exerting acute cytoprotective and chronic antifibrotic effects, respectively.

  9. The results suggest that PGRN (show GRN Proteins) may affect the differentiation of retinal precursor cells to photoreceptor cells through the HGF receptor signaling pathway.

  10. study demonstrates that co-activation of AKT (show AKT1 Proteins) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN (show FASN Proteins) pathway.

Human Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) interaction partners

  1. Data suggest that HGF, IL-20 (show IL20 Proteins), and IL-22 (show IL22 Proteins) in the serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before chemotherapy may be a prognostic of cancer progression.

  2. Studies indicate that the over-expression of hepatocyte growth factor (HGF) is valuable in colorectal cancer (CRC (show CALR Proteins)) prognosis.

  3. These results establish HGF/C-Met as a central organizing signal in blood vessel-directed tumor cell migration in vivo and highlight a promising role for C-Met inhibitors in blocking tumor cell streaming and metastasis in vivo, and for use in human trials.

  4. Furthermore, activation of HGF/Met signaling increased the expression and transcriptional activity of FOXM1 (show FOXM1 Proteins), and the cross talk between FOXM1 (show FOXM1 Proteins) and HGF/Met signaling promoted pancreatic ductal adenocarcinoma (PDA)growth and resistance to Met inhibition

  5. These data suggest that paxillin (show PXN Proteins) appears to influence major cell functions in a diverse range of prostate and breast cancer models. The responsiveness of cells to environmental factors such as HGF or BME may be influenced by paxillin (show PXN Proteins) status, although this seems to be dependent on cell type

  6. Fibronectin (show FN1 Proteins) and Hepatocyte Growth Factor were shown to be produced by lung fibroblasts and, furthermore, to enhance malignant pleural mesothelioma cell migration and invasion

  7. Glioblastoma patients with high expression of hepatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase (show MGMT Proteins) may benefit from onartuzumab plus bevacizumab chemotherapy.

  8. Plasma levels of HGF in PAH patients with mild disease were significantly higher than those in healthy controls, suggesting that plasma HGF has potential utility as a diagnostic biomarker for early PAH.

  9. Blood HGF was significantly higher in chronic hepatitis C patients with liver fibrosis compared to those without fibrosis.

  10. In summary, a decrease in VEGF-A (show VEGFA Proteins) and an increase in sVEGFR1 during chemotherapy and bevacizumab exposure can contribute to both chemotherapy (due to c-MET/b-catenin activation) and bevacizumab (due to low VEGF (show VEGFA Proteins) requirements) resistance. Because HGF levels decrease also during acquired resistance, alternative strategies to HGF-ligand inhibition should be investigated

Rabbit Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) interaction partners

  1. acute pulmonary embolism associated with an enhanced HGF expression in the lungs, the right ventricle, and the liver

Cow (Bovine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) interaction partners

  1. SNPs within bovine HGF gene were significantly associated with growth traits. This will provide a background for application of bovine HGF gene in the selection program in Chinese cattle.

  2. Treatment of the bovine satellite cells (BSC (show SLC12A2 Proteins)) with ephrin-A5 (show EFNA5 Proteins) causes a reduction in velocity with a concomitant increase in directed migration. Treatment of BSC (show SLC12A2 Proteins) with hepatocyte growth factor had no immediate effect on cell motility or migration.

  3. HGF transiently increases gene transcription of angiotensin-converting enzyme (show ACE Proteins)

Pig (Porcine) Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) interaction partners

  1. Combined administration of mesenchymal stem cells overexpressing IGF-1 (show IGF1 Proteins) and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

  2. In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1 (show IGF1 Proteins)/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.

HGF Protein Profile

Protein Summary

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with HGF

  • hepatocyte growth factor (HGF)
  • hepatocyte growth factor (Hgf)
  • hepatocyte growth factor (hepapoietin A; scatter factor) (HGF)
  • hepatocyte growth factor (hepapoietin A; scatter factor) (Hgf)
  • hepatocyte growth factor-like (LOC100525120)
  • met proto-oncogene (Met)
  • AI838057 protein
  • c-Met protein
  • C230052L06Rik protein
  • DFNB39 protein
  • F-TCF protein
  • HGF protein
  • HGF/SF protein
  • HGFB protein
  • HGFR protein
  • HPTA protein
  • NK1 protein
  • NK2 protein
  • Par4 protein
  • SF protein
  • SF/HGF protein

Protein level used designations for HGF

hepatocyte growth factor , SF , hepatopoeitin-A , hepatopoietin-A , scatter factor , fibroblast-derived tumor cytotoxic factor , lung fibroblast-derived mitogen , hepapoietin A , HGF alpha-chain , hepatocyte growth factor /scatter factor , HGF receptor , HGF/SF receptor , SF receptor , hepatocyte growth factor receptor , met proto-oncogene tyrosine kinase , proto-oncogene c-Met , scatter factor receptor , tyrosine-protein kinase Met

708316 Macaca mulatta
15234 Mus musculus
24446 Rattus norvegicus
3082 Homo sapiens
100730730 Cavia porcellus
100316908 Oryctolagus cuniculus
403441 Canis lupus familiaris
282879 Bos taurus
395941 Gallus gallus
493705 Felis catus
443075 Ovis aries
100525120 Sus scrofa
17295 Mus musculus
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