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IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation.
IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points.
Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review)
Analysis of structural determinants of alkali sensor IRR positive cooperativity.
IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age.
Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family
The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus.
The activation of IRR by alkali might be part of a local loop of signaling between the exocrine and endocrine parts of the pancreas where alkalinization of the juice facilitate insulin (show INS Proteins) release that increases the volume of secreted juice to control its pH and bicabonate content.
Disruption of insulin receptor-related receptor in mice impairs the renal response to alkali loading attested by development of metabolic alkalosis and decreased urinary bicarbonate excretion in response to this challenge
the insulin receptor tyrosine kinase family, comprising Ir, Igf1r (show IGF1R Proteins) and Irr, is required for the appearance of male gonads and thus for male sexual differentiation
Insulin receptor (show INSR Proteins) substrates 1 and 2 (IRS-1 (show IRS1 Proteins) and IRS-2 (show IRS2 Proteins)) were targeted and compared as central distributors of the insulin (show INS Proteins) signal, the insulin receptor (show INSR Proteins), the insulin-like growth factor 1 receptor (show IGF1R Proteins), and the insulin receptor-related receptor.
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
, insulin receptor-related protein
, insulin receptor-related receptor
, insulin receptor related tyrosine kinase
, insulin receptor-related protein-like