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Human MET ELISA Kit for Sandwich ELISA - ABIN1672788
Bin, Ma, Xu, Shi: Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action. in World journal of gastroenterology : WJG 2012
Show all 3 references for 1672788
c-Met overexpression is significantly associated with a poorer prognosis in esophageal cancer.. C-Met may serve as a potential novel prognostic biomarker for esophageal cancer patients (Meta-Analysis)
Concurrent MET silver in situ hybridization positivity and KRAS mutation may predict a high risk of recurrence in pancreatobiliary subtype of ampullary adenocarcinomas
Data suggest that combination regimens incorporating targeted inhibitors in patients with c-MET protein pathway activation could be of interest.
MET inhibition by SGX523 and EGFR (show EGFR ELISA Kits)-MET heterodimerisation are determined by EGFR (show EGFR ELISA Kits) genotype.
Report macrocyclic peptides targeting c-Met in gastric carcinoma.
HPV-16 E6 was confirmed to regulate microRNA miR-23b indirectly through the DNA methylation of host gene C9orf3 and thus induce c-MET and inhibit apoptosis in cervical cancer cells.
Studies provide evidence that MET amplification in non-small cell lung cancer is implicated in acquired resistance to EGFR (show EGFR ELISA Kits) inhibitors and has been reported in approximately one-fifth of cases with EGFR (show EGFR ELISA Kits) inhibitor resistance. [review]
Using an integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems, we identified previously unidentified gene fusions involving the MET oncogene (show RAB1A ELISA Kits) in approximately 10% of cases. These MET fusions activated mitogen-activated protein kinase (show MAPK1 ELISA Kits) (MAPK (show MAPK1 ELISA Kits)) signaling and, in cooperation with lesions compromising cell cycle regulation, induced aggressive glial tumors in vivo.
We have identified cooperation of hMet and beta-catenin (show CTNNB1 ELISA Kits) activation in a subset of Hepatocellular cancer patients and modeled this human disease in mice with a significant transcriptomic intersection; this model will provide novel insight into the biology of this tumor and allow us to evaluate novel therapies as a step toward precision medicine
ASM (show SMPD1 ELISA Kits) and ceramides, together with STX6 (show STX6 ELISA Kits) and cholesterol, constitute a new regulatory mechanism for the exit of Met from the Golgi during its biosynthetic route.
We found the roles of hepatocyte growth factor (HGF (show HGF ELISA Kits)) signaling in stria vascularis development for the first time and that lack of HGF (show HGF ELISA Kits) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (show HGF ELISA Kits) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva
c-Met has been found to attenuate lung injury and apoptosis in bronchial epithelial cells.
In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS (show RALGDS ELISA Kits) at Y752 in its RBD (show CACNA1D ELISA Kits), which blocks the binding of Ras to RalGDS (show RALGDS ELISA Kits).
study demonstrates that co-activation of AKT (show AKT1 ELISA Kits) and c-Met induces hepatocellular carcinoma development that depends on the mTORC1/FASN (show FASN ELISA Kits) pathway.
Molecular and functional studies revealed that ectopic Met expression in limb mesenchyme does not alter HGF (show HGF ELISA Kits) expression patterns and levels, but impairs HGF (show HGF ELISA Kits) bioavailability
miR-206 suppressed c-Met expression in gastric cancer and could function as a potent tumor suppressor in c-Met overexpressing tumors.
Meg3 overexpression in insulinoma cells down-regulated the expression of the protooncogene c-met.
our results support the concept of the acrosome as a lysosome-related organelle and provide evidence for the identification of MET as a tyrosine kinase receptor (show KDR ELISA Kits) that may play a role in fertilization.
We show that a subset of adult calcitonin gene-related peptide (CGRP (show CALCA ELISA Kits))-expressing myenteric neurons produce MET, the receptor for hepatocyte growth factor (show HGF ELISA Kits).
HGF and c-met inhibition by means of a novel monoclonal neutralizing antibody inhibits tumor growth in prostate cancer cells and in mouse xenografts.
possible cooperative role of the EGF (show EGF ELISA Kits) and HGF (show HGF ELISA Kits) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met