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Studies indicate that miR (show MLXIP ELISA Kits)-182 negatively regulated Met via direct binding to the Met 3'-untranslated region (3'-UTR (show UTS2R ELISA Kits)).
Selective MET tyrosine kinase (show TXK ELISA Kits) inhibitor SAR125844 has significant antitumour activity in patients with MET-amplified non-small cell lung carcinoma.
miR (show MLXIP ELISA Kits)-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL (show AXL ELISA Kits) and the interference with the activation of downstream signaling.
The hepatocyte growth factor (HGF (show HGF ELISA Kits))-MET receptor tyrosine kinase (show RET ELISA Kits) signaling pathway
Crizotinib is active and well tolerated in advanced, metastatic papillary renal cell carcinoma type 1, achieving objective responses and long-lasting disease control in patients with MET mutations or amplification.
Data show that cancer-associated fibroblasts (CAFs (show TBX1 ELISA Kits))-derived hepatocyte growth factor (HGF (show HGF ELISA Kits)) or recombinant HGF (show HGF ELISA Kits) activated c-Met/phosphoinositide 3-kinase (PI3K (show PIK3CA ELISA Kits))/Akt (show AKT1 ELISA Kits) and glucose-regulated protein 78 (GRP78 (show HSPA5 ELISA Kits)) signalling pathways in ovarian cancer cells.
Data show that MET is the direct target of miR (show MLXIP ELISA Kits)-206 in lung cancer cells.
Results indicate that miR (show MLXIP ELISA Kits)-329 played a pivotal role in lung cancer through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic MET.
nMet accelerated HCC (show FAM126A ELISA Kits) tumorigenesis and metastasis via the activation of TAK1 (show MAP3K7 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) pathway.
Data show that afatinib resistant clones were selectively killed by knock down of ERBB3 (show ERBB3 ELISA Kits) + c-MET + c-KIT (show KIT ELISA Kits), but not by the individual or doublet knock down combinations, and the combination of afatinib with the SRC (show SRC ELISA Kits) family inhibitor dasatinib killed afatinib resistant H1975 cells in a greater than additive fashion.
possible cooperative role of the EGF (show EGF ELISA Kits) and HGF (show HGF ELISA Kits) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met
, hepatocyte growth factor
, hepatoCyte growth factor receptor
, met proto-oncogene
, Hepatocyte growth factor receptor
, hepatocyte growth factor receptor-like
, Proto-oncogene c-Met
, Scatter factor receptor
, Tyrosine-protein kinase Met