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Mouse (Murine) Neuregulin 1 ELISA Kit for Sandwich ELISA - ABIN424277
Zhang, Zhao, Wu, Kong, Sun, Cao, Zhang, Wang, Zhang, Jin, Li: Therapeutic effect of co-transplantation of neuregulin-1-transfected Schwann cells and bone marrow stromal cells on spinal cord hemisection syndrome. in Neuroscience letters 2011
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Human Neuregulin 1 ELISA Kit for Sandwich ELISA - ABIN414850
Das, Czarnek, Bzowska, M??yk-Kope?, Stali?ska, Wyroba, Sroka, Jucha, Deneka, Stok?osa, Ogonek, Swartz, Madeja, Bereta: ADAM17 silencing in mouse colon carcinoma cells: the effect on tumoricidal cytokines and angiogenesis. in PLoS ONE 2012
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Rat (Rattus) Neuregulin 1 ELISA Kit for Sandwich ELISA - ABIN431608
Dang, Cai, Zhang, Liang, Lv, Guo, Yang, Zhu, Jiang: Dysregulation of Neuregulin-1/ErbB signaling in the prefrontal cortex and hippocampus of rats exposed to chronic unpredictable mild stress. in Physiology & behavior 2015
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Mouse (Murine) Neuregulin 1 ELISA Kit for Sandwich ELISA - ABIN425724
Deuschle, Birkel, Hambruch, Hornberger, Kinzel, Perovi?-Ottstadt, Schulz, Hahn, Burnet, Kremoser: The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein. in International journal of cancer. Journal international du cancer 2015
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Human Neuregulin 1 ELISA Kit for Sandwich ELISA - ABIN418227
Wu, Xie, Liu, He, Benitez, Buckanovich, Lubman: Identification and confirmation of differentially expressed fucosylated glycoproteins in the serum of ovarian cancer patients using a lectin array and LC-MS/MS. in Journal of proteome research 2012
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These results suggest that the neuropsin (show KLK8 ELISA Kits)-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB ELISA Kits)-expressing interneurons, and that neuropsin (show KLK8 ELISA Kits) regulates E/I balance and gamma oscillations through NRG1-ErbB4 (show ERBB4 ELISA Kits) signaling toward parvalbumin (show PVALB ELISA Kits)-expressing interneurons.
we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 (show ERBB4 ELISA Kits) activation in macrophages
Results show that at ventral hippocampus-nucleus accumbens synapses, presynaptic type III Nrg1 bidirectional signaling controls the establishment of ventral hippocampus-nucleus accumbens glutamatergic synapses. Type III Nrg1 back-signaling contributes to functional synaptic vesicle clustering and neurotransmitter vesicle release.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (show ERBB4 ELISA Kits) in regulating the initiation of critical period visual cortical plasticity.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
These results demonstrate for the first time in vivo interplay between Nrg1 and endocannabinoids in the brain.
Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 (show ERBB4 ELISA Kits) signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
NRG1 enhanced excitatory drive onto fast spiking interneurons, which inhibited ocular dominance plasticity in juveniles but rescued plasticity in transgenics with hypoexcitable fast-spiking interneurons
we described a RET (show RET ELISA Kits)-ER81 (show ETV1 ELISA Kits)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
NRG1 genotype is associated with substance use.
Significant genetic risk for Hirschsprung disease (HSCR (show EDNRB ELISA Kits)) was imparted by rs2435357 and rs2506030 at RET (show RET ELISA Kits) and by rs12707682 at SEMA3 in a Chinese population. No evidence was found of a genetic association between HSCR (show EDNRB ELISA Kits) and either of the NRG1 SNPs rs7835688 and rs16879552, at either allele or genotype level.
High HRG1 (show SLC48A1 ELISA Kits) expression is associated with breast cancer.
Results showed that heregulin-1ss mRNA was downregulated in 82 % of patients with hepatocellular carcinoma.
NRG1/ErbB2 (show ERBB2 ELISA Kits)/Src (show SRC ELISA Kits)/PTK2 (show PTK2 ELISA Kits) signaling pathway may be a novel regulator of keloid fibroblast migration.
The plasma soluble NRG1 level was significantly higher in mild and moderate Alzheimer's disease patients compared to controls.
Data indicate a role for AXL receptor tyrosine kinase (AXL (show AXL ELISA Kits)) in regulating the nuclear translocation of epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) and suggest that AXL (show AXL ELISA Kits)-mediated SRC (show SRC ELISA Kits) family kinases (SFKs) and neuregulin-1 (NRG1) expression promote this process.
NRG1FISH detection should be considered in patients with IMA pan-negative for known driver oncogenes. These results might suggest that NRG1 fusion is more frequent in IMA from Asian patient.
Results suggest genetic variation at the 5' and 3' ends of NRG1 are associated with schizophrenia. [Meta-Analysis]
Nrg1 acts as an axonal signal that drives virtually all stages of Schwann cell development and myelination.Nrg1 plays important role in the peripheral nerve injury and nerve repair.[review]
Data suggest that epidermal growth factor receptor (show EGFR ELISA Kits) B [ErbB (show EGFR ELISA Kits)] isoforms and their ligands (epidermal growth factor (show EGF ELISA Kits) [EGF (show EGF ELISA Kits)], amphiregulin (show AREG ELISA Kits) [AREG (show AREG ELISA Kits)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR ELISA Kits) receptors.
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 ELISA Kits) and ErbB4 (show ERBB4 ELISA Kits), in main gastrointestinal tissues of the non-human primate rhesus monkey.
we observed the activation of Notch (show NOTCH1 ELISA Kits) signaling in cardiomyocytes adjacent to those undergoing apical constriction, and we showed that this activation is positively regulated by Neuregulin signaling.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (show EGF ELISA Kits)-like ligand(s) activates the ErbB2 (show ERBB2 ELISA Kits)/ErbB4 (show ERBB4 ELISA Kits) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (show EGF ELISA Kits) family member requirements for an evolutionary conserved process.
Notch1 (show NOTCH1 ELISA Kits) activation induces expression of ephrin b2a (efnb2a (show EFNB2 ELISA Kits)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 ELISA Kits) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 ELISA Kits) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (show ERBB3 ELISA Kits) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (show DISC1 ELISA Kits) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 ELISA Kits)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 ELISA Kits) and ErbB3 (show ERBB3 ELISA Kits) during regeneration
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, neuregulin 1 type III beta 3
, membrane-bound isoform
, neuregulin 1 alpha isoform