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Browse our Neuregulin 1 Proteins (NRG1)

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Neuregulin 1 Proteins (NRG1)
On are 51 Neuregulin 1 (NRG1) Proteins from 12 different suppliers available. Additionally we are shipping Neuregulin 1 Antibodies (238) and Neuregulin 1 Kits (59) and many more products for this protein. A total of 382 Neuregulin 1 products are currently listed.
6030402G23Rik, ARIA, D230005F13Rik, DKFZp459A1838, GGF, GGF2, GGFII, heregulin, Hgl, HPRG, HRG, HRG1, HRGA, HRGalpha, HRGP, MST131, NDF, NRG-1, NRG1, nrg1-A, pro-neuregulin-1, SMDF, THPH11, wu:fm70e01
list all proteins Gene Name GeneID UniProt
NRG1 3273 P04196
NRG1 171016 Q99PS8
NRG1 211323  

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Neuregulin 1 Proteins (NRG1) by Origin

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Top referenced Neuregulin 1 Proteins

  1. Human Neuregulin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2666853 : Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 7 references for ABIN2666853

  2. Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066 : Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012 (PubMed)

More Proteins for Neuregulin 1 Interaction Partners

Rhesus Monkey Neuregulin 1 (NRG1) interaction partners

  1. The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins), in main gastrointestinal tissues of the non-human primate rhesus monkey.

Zebrafish Neuregulin 1 (NRG1) interaction partners

  1. Notch1 (show NOTCH1 Proteins) activation induces expression of ephrin b2a (efnb2a (show EFNB2 Proteins)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 Proteins) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 Proteins) and nrg1 expression

  2. These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.

  3. These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.

  4. ErbB3 (show ERBB3 Proteins) signaling is required for normal migration of trunk, but not cranial, neural crest cells

  5. Disc1 (show DISC1 Proteins) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.

  6. NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) during regeneration

Human Neuregulin 1 (NRG1) interaction partners

  1. Orbitofrontal sulcogyral pattern formation in schizophrenia may be associated with NRG1 allele frequency, which is closely related to neurodevelopment.

  2. This study found a significant association between genetic variation at NRG1 and the modulation of small-worldness properties of the functional cortical network during the performance of an odd-ball task in healthy subjects.

  3. Neuregulin-1 has now been accepted to have therapeutic potential in cardiovascular disease. The preclinical and clinical researches of NRG1 have demonstrated its advantage effects in cardiac function with multi-target cardiovascular biology and pathophysiology, but its influence on cardiac electrophysiology is rarely involved, which is a very important aspect and should not be ignored. [review]

  4. Results suggest that silibinin is a potential anti-cancer drug to inhibit proliferative and invasive characteristics of the epithelial ovarian cancer (EOC) cells that exhibit an autocrine heregulin (HRG)/HER3 (show ERBB3 Proteins) protein (HRG/HER3 (show ERBB3 Proteins)) pathway.

  5. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 (show DISC1 Proteins) and NRG1 genes could be associated with schizophrenia in the Chinese population.

  6. SZuggest the use of polymeric PLGA and PEG (show PAEP Proteins)-PLGA microparticles as delivery systems for NRG1 in the treatment of myocardial infarction.

  7. NRG1 was a shared common susceptibility gene for major mental disorders in Han Chinese population.

  8. overexpression of phospho-ALK and alternative receptor tyrosine kinases such as phospho-EGFR (show EGFR Proteins), phospho-HER3 (show ERBB3 Proteins), and phospho-IGFR-1R was observed in both resistant cell lines. Additionally, NRG1, a ligand for HER3 (show ERBB3 Proteins), is upregulated and responsible for resistance by activating the EGFR (show EGFR Proteins) family pathways through the NRG1-HER3 (show ERBB3 Proteins)-EGFR (show EGFR Proteins) axis.

  9. Study found significant association between NRG1 (rs35753505) gene polymorphism and the risk of temporal lobe epilepsy in a Chinese Han population

  10. This study demonstrate dysregulation of the NRG1-ErbB4 (show ERBB4 Proteins)/3 axis in both human and mouse ALS (show IGFALS Proteins) and to provide support for NRG1 supplementation as a possible therapeutic option for motor neuron disease

Rabbit Neuregulin 1 (NRG1) interaction partners

  1. The structure confirms that the N2 domain, which along with the N1 domain, forms an important molecular interaction site on HRG (show HRG Proteins), possesses a cystatin (show CST3 Proteins)-like fold composed of a 5-stranded antiparallel beta-sheet wrapped around a 5-turn alpha-helix.

Mouse (Murine) Neuregulin 1 (NRG1) interaction partners

  1. Whole-cell recording showed that perinatal NRG1 pretreatment diminished inhibitory miniature synaptic currents as well as GABAA (show GABRg1 Proteins) receptor sensitivity. These results collectively suggest that perinatal exposure to neuregulin-1 results in the disinhibition of nigral dopamine neurons to influence their firing properties at the adult stage when the behavioral deficits are evident.

  2. NRG1 mediates the preventive effects of olanzapine.

  3. this study investigated whether an unhealthy diet [i.e. high fat diet (HFD)] impacts on the behaviour of a genetic mouse model for the schizophrenia risk gene neuregulin 1 (i.e. transmembrane domain Nrg1 mutant mice: Nrg1 HET). Female Nrg1 HET and wild-type-like littermates (WT) were fed with either HFD or a control chow diet.

  4. Authors found that injury to the olfactory epithelium specifically upregulates the Neuregulin1 Type I isoform bringing the expression pattern adjacent to cells expressing both ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) which is compatible with active signaling, supporting a functional role for Neuregulin1 specifically during regeneration.

  5. These results suggest a mechanism by which cross-talk between DISC1 (show DISC1 Proteins) and NRG1-ErbB4 (show ERBB4 Proteins) signalling may contribute to these deficits.

  6. NRG1 treatments improve glucose tolerance in db/db (show LEPR Proteins) mice. This effect could be mediated through inhibition of hepatic gluconeogenesis

  7. Results suggest a regulatory function of E-cadherin (show CDH1 Proteins) that modulates Nrg1 signaling and promotes Schwann cell myelin formation

  8. CD44 (show CD44 Proteins) and pro-NRG1 are posttranslationally modified at their intracellular domains.

  9. analysis of hippocampal circuitry via Aph1b-gamma-secretase/neuregulin 1 signalling

  10. Nrg1 confers vulnerability to repeated stress-induced sensorimotor gating deficits, dendritic spine growth in the mPFC, and an abberant endocrine response in adolescence in mice.

Cow (Bovine) Neuregulin 1 (NRG1) interaction partners

  1. Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.

Xenopus laevis Neuregulin 1 (NRG1) interaction partners

  1. Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR Proteins) receptors.

Neuregulin 1 (NRG1) Protein Profile

Protein Summary

The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).

Alternative names and synonyms associated with Neuregulin 1 (NRG1)

  • neuregulin 1 (NRG1)
  • neuregulin 1 (nrg1)
  • neuregulin 1 (Nrg1)
  • histidine-rich glycoprotein (HRG)
  • histidine-rich glycoprotein (Hrg)
  • 6030402G23Rik protein
  • ARIA protein
  • D230005F13Rik protein
  • DKFZp459A1838 protein
  • GGF protein
  • GGF2 protein
  • GGFII protein
  • heregulin protein
  • Hgl protein
  • HPRG protein
  • HRG protein
  • HRG1 protein
  • HRGA protein
  • HRGalpha protein
  • HRGP protein
  • MST131 protein
  • NDF protein
  • NRG-1 protein
  • NRG1 protein
  • nrg1-A protein
  • pro-neuregulin-1 protein
  • SMDF protein
  • THPH11 protein
  • wu:fm70e01 protein

Protein level used designations for Neuregulin 1 Proteins (NRG1)

neuregulin 1 , pro-neuregulin-1, membrane-bound isoform , histidine-proline-rich glycoprotein , histidine-rich glycoprotein 1 , MSTP131 , glial growth factor , heregulin, alpha (45kD, ERBB2 p185-activator) , neu differentiation factor , neuregulin 1 type IV beta 1a , neuregulin 1 type IV beta 3 , pro-NRG1 , sensory and motor neuron derived factor , heregulin , type I neuregulin 1 , type III neuregulin 1 , neuregulin 1 type III beta 3 , neuregulin 1 alpha isoform , membrane-bound isoform , HRG-alpha , heregulin-alpha

464102 Pan troglodytes
696275 Macaca mulatta
796461 Danio rerio
100061417 Equus caballus
100171905 Pongo abelii
100472692 Ailuropoda melanoleuca
100500942 Cavia porcellus
100587299 Nomascus leucogenys
3273 Homo sapiens
100009395 Oryctolagus cuniculus
171016 Rattus norvegicus
3084 Homo sapiens
211323 Mus musculus
112400 Rattus norvegicus
281361 Bos taurus
100008920 Oryctolagus cuniculus
100721267 Cavia porcellus
373906 Gallus gallus
482861 Canis lupus familiaris
678677 Ovis aries
373595 Xenopus laevis
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