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Browse our Neuregulin 1 Proteins (NRG1)

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Neuregulin 1 Proteins (NRG1)
On are 49 Neuregulin 1 (NRG1) Proteins from 12 different suppliers available. Additionally we are shipping Neuregulin 1 Antibodies (212) and Neuregulin 1 Kits (62) and many more products for this protein. A total of 356 Neuregulin 1 products are currently listed.
6030402G23Rik, ARIA, D230005F13Rik, DKFZp459A1838, GGF, GGF2, GGFII, heregulin, Hgl, HPRG, HRG, HRG1, HRGA, HRGalpha, HRGP, MST131, NDF, NRG-1, NRG1, nrg1-A, pro-neuregulin-1, SMDF, THPH11, wu:fm70e01
list all proteins Gene Name GeneID UniProt
NRG1 3273 P04196
NRG1 171016 Q99PS8
NRG1 211323  

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Neuregulin 1 Proteins (NRG1) by Origin

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Top referenced Neuregulin 1 Proteins

  1. Human Neuregulin 1 Protein expressed in Escherichia coli (E. coli) - ABIN2666853 : Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 7 references for ABIN2666853

  2. Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066 : Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012 (PubMed)

More Proteins for Neuregulin 1 Interaction Partners

Rhesus Monkey Neuregulin 1 (NRG1) interaction partners

  1. The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins), in main gastrointestinal tissues of the non-human primate rhesus monkey.

Zebrafish Neuregulin 1 (NRG1) interaction partners

  1. Notch1 (show NOTCH1 Proteins) activation induces expression of ephrin b2a (efnb2a (show EFNB2 Proteins)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 Proteins) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 Proteins) and nrg1 expression

  2. These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.

  3. These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.

  4. ErbB3 (show ERBB3 Proteins) signaling is required for normal migration of trunk, but not cranial, neural crest cells

  5. Disc1 (show DISC1 Proteins) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.

  6. NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) during regeneration

Human Neuregulin 1 (NRG1) interaction partners

  1. Data show that isoform beta2 of the heregulin (HRGbeta2) localizes at telomeres with the telomere-associated proteins TRF2 and RAP1.

  2. Data indicate telomere-binding protein RAP1 (show RABGEF1 Proteins) as an interacting partner of isoform beta2 of the heregulin (HRGbeta2).

  3. findings newly identify a physiological function of the NRG1-ErbB2 (show ERBB2 Proteins)-ErbB3 (show ERBB3 Proteins) axis in trophoblast survival during human placental development.

  4. HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  5. Neuregulin-activated ERBB4 (show ERBB4 Proteins) induces the SREBP-2 (show SREBF2 Proteins) cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.

  6. HRG could inhibit hepatocellular carcinoma cell proliferation via the FGF-Erk1/2 signaling pathway by reducing Erk1/2 phosphorylation.

  7. while transcript and protein levels of EGFR (show EGFR Proteins) and ErbB2 (show ERBB2 Proteins) were up-regulated or unaffected, respectively, hepatitis c virus induced a substantial reduction of ErbB3 (show ERBB3 Proteins) and ErbB4 (show ERBB4 Proteins) expression.

  8. Polymorphisms of dopamine pathway gene NRG1 is associated with cognitive performance in Bipolar disorder.

  9. NRG1 promotes the proliferation and migration of coronary artery smooth muscle cells by enhancing the phosphorylation of ErbB2 (show ERBB2 Proteins), ErbB3 (show ERBB3 Proteins) and ErbB4 (show ERBB4 Proteins).

  10. In this study, we developed an anti-ErbB4 (show ERBB4 Proteins) mAb (clone P6-1) that suppresses NRG-dependent activation of ErbB4 (show ERBB4 Proteins) and examined its effect on breast cancer cell proliferation in the extracellular matrix.

Rabbit Neuregulin 1 (NRG1) interaction partners

  1. The structure confirms that the N2 domain, which along with the N1 domain, forms an important molecular interaction site on HRG (show HRG Proteins), possesses a cystatin (show CST3 Proteins)-like fold composed of a 5-stranded antiparallel beta-sheet wrapped around a 5-turn alpha-helix.

Mouse (Murine) Neuregulin 1 (NRG1) interaction partners

  1. Authors found that injury to the olfactory epithelium specifically upregulates the Neuregulin1 Type I isoform bringing the expression pattern adjacent to cells expressing both ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) which is compatible with active signaling, supporting a functional role for Neuregulin1 specifically during regeneration.

  2. These results suggest a mechanism by which cross-talk between DISC1 (show DISC1 Proteins) and NRG1-ErbB4 (show ERBB4 Proteins) signalling may contribute to these deficits.

  3. NRG1 treatments improve glucose tolerance in db/db (show LEPR Proteins) mice. This effect could be mediated through inhibition of hepatic gluconeogenesis

  4. Results suggest a regulatory function of E-cadherin (show CDH1 Proteins) that modulates Nrg1 signaling and promotes Schwann cell myelin formation

  5. CD44 (show CD44 Proteins) and pro-NRG1 are posttranslationally modified at their intracellular domains.

  6. analysis of hippocampal circuitry via Aph1b-gamma-secretase/neuregulin 1 signalling

  7. Nrg1 confers vulnerability to repeated stress-induced sensorimotor gating deficits, dendritic spine growth in the mPFC, and an abberant endocrine response in adolescence in mice.

  8. interaction between NRG1 genotype and prenatal immune challenge on expression of behavioral phenotypes related to schizophrenia; findings indicate complexity of gene x environment interactions that regulate behavioral phenotypes relevant to psychotic illness

  9. An optimal level of NRG1 signaling balances excitatory and inhibitory neurotransmission in the cortex.

  10. ARIA regulates macrophage foam cell formation at least in part by modulating ACAT-1 (show SOAT1 Proteins) expression.

Cow (Bovine) Neuregulin 1 (NRG1) interaction partners

  1. Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.

Xenopus laevis Neuregulin 1 (NRG1) interaction partners

  1. Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR Proteins) receptors.

Neuregulin 1 (NRG1) Protein Profile

Protein Summary

The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).

Alternative names and synonyms associated with Neuregulin 1 (NRG1)

  • neuregulin 1 (NRG1)
  • neuregulin 1 (nrg1)
  • neuregulin 1 (Nrg1)
  • histidine-rich glycoprotein (HRG)
  • histidine-rich glycoprotein (Hrg)
  • 6030402G23Rik protein
  • ARIA protein
  • D230005F13Rik protein
  • DKFZp459A1838 protein
  • GGF protein
  • GGF2 protein
  • GGFII protein
  • heregulin protein
  • Hgl protein
  • HPRG protein
  • HRG protein
  • HRG1 protein
  • HRGA protein
  • HRGalpha protein
  • HRGP protein
  • MST131 protein
  • NDF protein
  • NRG-1 protein
  • NRG1 protein
  • nrg1-A protein
  • pro-neuregulin-1 protein
  • SMDF protein
  • THPH11 protein
  • wu:fm70e01 protein

Protein level used designations for Neuregulin 1 Proteins (NRG1)

neuregulin 1 , pro-neuregulin-1, membrane-bound isoform , histidine-proline-rich glycoprotein , histidine-rich glycoprotein 1 , MSTP131 , glial growth factor , heregulin, alpha (45kD, ERBB2 p185-activator) , neu differentiation factor , neuregulin 1 type IV beta 1a , neuregulin 1 type IV beta 3 , pro-NRG1 , sensory and motor neuron derived factor , heregulin , type I neuregulin 1 , type III neuregulin 1 , neuregulin 1 type III beta 3 , neuregulin 1 alpha isoform , membrane-bound isoform , HRG-alpha , heregulin-alpha

464102 Pan troglodytes
696275 Macaca mulatta
796461 Danio rerio
100061417 Equus caballus
100171905 Pongo abelii
100472692 Ailuropoda melanoleuca
100500942 Cavia porcellus
100587299 Nomascus leucogenys
3273 Homo sapiens
100009395 Oryctolagus cuniculus
171016 Rattus norvegicus
3084 Homo sapiens
211323 Mus musculus
112400 Rattus norvegicus
281361 Bos taurus
100008920 Oryctolagus cuniculus
100721267 Cavia porcellus
373906 Gallus gallus
482861 Canis lupus familiaris
678677 Ovis aries
373595 Xenopus laevis
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