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Human Neuregulin 1 Protein expressed in Human Cells - ABIN2004422
Holmes, Sliwkowski, Akita, Henzel, Lee, Park, Yansura, Abadi, Raab, Lewis: Identification of heregulin, a specific activator of p185erbB2. in Science (New York, N.Y.) 1992
Show all 2 Pubmed References
Human Neuregulin 1 Protein expressed in Wheat germ - ABIN1307066
Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid. in The Journal of biological chemistry 2012
The present research focused on morphological distribution of Nrg1 and its receptors, ErbB2 (show ERBB2 Proteins) and ErbB4 (show ERBB4 Proteins), in main gastrointestinal tissues of the non-human primate rhesus monkey.
these results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF (show EGF Proteins)-like ligand(s) activates the ErbB2 (show ERBB2 Proteins)/ErbB4 (show ERBB4 Proteins) pathway, either through functioning as the primary ligand or acting in a redundant manner. Overall, our work provides an example of cross-species differences in EGF (show EGF Proteins) family member requirements for an evolutionary conserved process.
Notch1 (show NOTCH1 Proteins) activation induces expression of ephrin b2a (efnb2a (show EFNB2 Proteins)) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch (show NOTCH1 Proteins) activation in the absence of cardiac contraction rescues efnb2a (show EFNB2 Proteins) and nrg1 expression
These findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
ErbB3 (show ERBB3 Proteins) signaling is required for normal migration of trunk, but not cranial, neural crest cells
Disc1 (show DISC1 Proteins) and nrg1 function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.
NRG1 and PI3K functionally interact with ErbB2 (show ERBB2 Proteins) and ErbB3 (show ERBB3 Proteins) during regeneration
Nrg1 acts as an axonal signal that drives virtually all stages of Schwann cell development and myelination.Nrg1 plays important role in the peripheral nerve injury and nerve repair.[review]
HRG/HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins) signaling promotes AhR (show AHR Proteins)-mediated Memo-1 (show MEMO1 Proteins) expression and migration in colorectal cancer
once infertility is established the HRG C633T SNP seems to be important for male infertility and pregnancy rate following IVF (show SCN5A Proteins)
We also demonstrate that the effects of RET (show RET Proteins) and NRG1 are universal across European and Asian ancestries. In contrast, we detected a European-specific association of a low-frequency variant, rs80227144, in SEMA3. Conditional analyses on the lead SNPs revealed a secondary association signal, corresponding to an Asian-specific, low-frequency missense variant encoding RET (show RET Proteins) p.Asp489Asn
primary aromatase (show CYP19A1 Proteins) inhibitor treatment modulates expression of HER-family members as well as EGFR1 (show EGFR Proteins) and NRG1 in HER-2/neu (show ERBB2 Proteins) non-amplified breast cancers in vivo
These data highlight the complex divalent metal-dependent regulatory mechanisms that govern HRG function.
GGF2 may improve contractile performance in the failing rat heart and that infrequent exposure to GGF2 may improve LV function
these results suggest that changes in Nrg1 signaling may influence the pathological development of AD, and exogenous Nrg1 may serve as a potential candidate for the prevention and treatment of AD.
Orbitofrontal sulcogyral pattern formation in schizophrenia may be associated with NRG1 allele frequency, which is closely related to neurodevelopment.
This study found a significant association between genetic variation at NRG1 and the modulation of small-worldness properties of the functional cortical network during the performance of an odd-ball task in healthy subjects.
The structure confirms that the N2 domain, which along with the N1 domain, forms an important molecular interaction site on HRG (show HRG Proteins), possesses a cystatin (show CST3 Proteins)-like fold composed of a 5-stranded antiparallel beta-sheet wrapped around a 5-turn alpha-helix.
Results demonstrate for the first time a link between a mutation of a schizophrenia risk gene, neuregulin 1 and altered neuronal resonance properties in sensory cortex.
findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 (show ERBB4 Proteins) in regulating the initiation of critical period visual cortical plasticity.
Data show that laminin alpha2beta1gamma1 (Lm211) can inhibit neuregulin 1 type III (Nrg1III) by limiting protein kinase A (PKA) activation, which is required to initiate myelination.
These results demonstrate for the first time in vivo interplay between Nrg1 and endocannabinoids in the brain.
Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 (show ERBB4 Proteins) signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
NRG1 enhanced excitatory drive onto fast spiking interneurons, which inhibited ocular dominance plasticity in juveniles but rescued plasticity in transgenics with hypoexcitable fast-spiking interneurons
we described a RET (show RET Proteins)-ER81 (show ETV1 Proteins)-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ
Co-disruption of DISC1 (show DISC1 Proteins) and NRG1, indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP Proteins) gene expression in a mouse schizophrenia model.
In mice, NRG1 type III plays a key role not only in myelination but also in migration of Schwann cell precursors.
LH induction of NRG1 directly drives the proliferation of Leydig cells in the infant testis, leading to an obligatory number of adult Leydig cells required for the production of sufficient androgen to support and maintain spermatogenesis and sexual behavior of adult male mice.
Data suggest that epidermal growth factor receptor (show EGFR Proteins) B [ErbB (show EGFR Proteins)] isoforms and their ligands (epidermal growth factor (show EGF Proteins) [EGF (show EGF Proteins)], amphiregulin (show AREG Proteins) [AREG (show AREG Proteins)], and neuregulin-1 [NRG1]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
Cloning of a novel isoform of NRG1 (IgNRG1beta2) containing an immunoglobulin-like domain which is probably essential for efficient interaction with ErbB (show EGFR Proteins) receptors.
The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD).
, pro-neuregulin-1, membrane-bound isoform
, histidine-proline-rich glycoprotein
, histidine-rich glycoprotein 1
, glial growth factor
, heregulin, alpha (45kD, ERBB2 p185-activator)
, neu differentiation factor
, neuregulin 1 type IV beta 1a
, neuregulin 1 type IV beta 3
, sensory and motor neuron derived factor
, type I neuregulin 1
, type III neuregulin 1
, neuregulin 1 type III beta 3
, neuregulin 1 alpha isoform
, membrane-bound isoform