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These observations encourage investigation of the neurobiology of NRG3 isoforms and highlight inhibition of NRG3 signaling as a potential target for psychiatric treatment development.
common variants of GABRG2 (show GABRG2 Proteins), RELN (show RELN Proteins) and NRG3 and the GABRG2 (show GABRG2 Proteins)-RELN (show RELN Proteins)-PTCH1 (show PTCH1 Proteins) interaction networks might confer altered susceptibility to Hirschsprung disease.
these data suggest that Nrg3/ErbB4 (show ERBB4 Proteins) signaling may be an important factor in nicotine dependence.
This study demonstrated that genetic variants in the NRG3 gene play a role in alzheimer disease and revealed that SNPs in the NRG3 genes were more strongly associated with onset age of Alzherimer disease.
An association between rs10748842 genotype in neuregulin 3 does not fit a simple inefficiency model of risk association in dorsolateral prefrontal cortex physiology.
NRG3 may be a susceptibility gene for Hirschsprung's disease in a Chinese population.
Neuregulin 3 rs6584400 genetic carriers are associated with psychotic symptoms and attention performance in schizophrenia.
no association of SNPs or haplotypes with risk of schizophrenia in Han Chinese population
Our results suggest a role for NRG3 in HSCR (show EDNRB Proteins) etiology and provide insights into the relative contribution of structural variants in both syndromic and non-syndromic HSCR (show EDNRB Proteins).
NRG3 polymorphisms and haplotypes were similar between schizophrenia patients and healthy controls of Korean ethnicity
This study demonistrated that Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia.
used positional cloning to narrow the interval containing scaramanga (ska) to a 75.6-kb interval containing the distal part of the Neuregulin3 (Nrg3) gene
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
, pro-neuregulin-3, membrane-bound isoform-like
, neuregulin 3 variant 1
, neuregulin 3 variant 10
, neuregulin 3 variant 11
, neuregulin 3 variant 12
, neuregulin 3 variant 13
, neuregulin 3 variant 14
, neuregulin 3 variant 3
, neuregulin 3 variant 4
, neuregulin 3 variant 5
, neuregulin 3 variant 6
, neuregulin 3 variant 7
, neuregulin 3 variant 8
, neuregulin 3 variant 9
, neuregulin-3-like polypeptide
, pro-neuregulin-3, membrane-bound isoform