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Human Neuregulin 4 Protein expressed in Wheat germ - ABIN1313026
Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. in American journal of physiology. Heart and circulatory physiology 2012
High serum Nrg4 levels are associated with type 2 diabetes mellitus.
NRG4 and its receptor ErbB4 (show ERBB4 Proteins) are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 (show ERBB4 Proteins) signaling may be a novel pathway for therapeutic intervention or prevention in NEC.
Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD).
results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
Pharmacological inhibition of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4 (show ERBB4 Proteins).
NRG4 overexpression is associated with advanced-stage prostate cancer
describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide (show HP Proteins)
NRG4 was positive in almost all breast cancers studied.
Neuregulin-4 expression is downregulated during urinary bladder cancer progression
Pharmacological inhibition of PI3K/Akt (show AKT1 Proteins) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR\; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999
, pro-neuregulin-4, membrane-bound isoform
, heregulin 4