Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human Neuregulin 4 Protein expressed in Wheat germ - ABIN1313026
Liu, Tefft, Roberts, Zhang, Ren, Li, Huang, Zhang, Phillips, Wu: Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. in American journal of physiology. Heart and circulatory physiology 2012
NRG4 and its receptor ErbB4 (show ERBB4 Proteins) are present in human breast milk and developing human intestine, respectively. Thus, NRG4-ErbB4 (show ERBB4 Proteins) signaling may be a novel pathway for therapeutic intervention or prevention in NEC.
Nrg4 might have a protective role in the development of Non-alcoholic fatty liver disease (NAFLD).
results establish Nrg4 as a brown fat-enriched endocrine factor with therapeutic potential for the treatment of obesity-associated disorders, including type 2 diabetes and nonalcoholic fatty liver disease (NAFLD).
Pharmacological inhibition of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4 (show ERBB4 Proteins).
NRG4 overexpression is associated with advanced-stage prostate cancer
describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide (show HP Proteins)
NRG4 was positive in almost all breast cancers studied.
Neuregulin-4 expression is downregulated during urinary bladder cancer progression
Pharmacological inhibition of PI3K/Akt (show AKT1 Proteins) signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR\; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999
, pro-neuregulin-4, membrane-bound isoform
, heregulin 4