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Browse our PDGFRA Proteins (PDGFRA)

Full name:
Platelet-Derived Growth Factor Receptor, alpha Polypeptide Proteins (PDGFRA)
On www.antibodies-online.com are 28 Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Proteins from 8 different suppliers available. Additionally we are shipping PDGFRA Antibodies (421) and PDGFRA Kits (41) and many more products for this protein. A total of 519 PDGFRA products are currently listed.
Synonyms:
AI115593, APDGFR, CD140A, PDGFACE, PDGFR, PDGFR-2, PDGFR-A, PDGFR2, RHEPDGFRA
list all proteins Gene Name GeneID UniProt
PDGFRA 18595 P26618
PDGFRA 25267 P20786
PDGFRA 5156 P16234

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PDGFRA Proteins (PDGFRA) by Origin

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Top referenced PDGFRA Proteins

  1. Human PDGFRA Protein expressed in Human Cells - ABIN2003042 : Matsui, Heidaran, Miki, Popescu, La Rochelle, Kraus, Pierce, Aaronson: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. in Science (New York, N.Y.) 1989 (PubMed)
    Show all 3 references for ABIN2003042

  2. Human PDGFRA Protein expressed in Baculovirus infected Insect Cells - ABIN2003046 : Choudhury, Grandaliano, Jin, Katz, Abboud: Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells. in Kidney international 2000 (PubMed)
    Show all 2 references for ABIN2003046

  3. Human PDGFRA Protein expressed in Escherichia coli (E. coli) - ABIN667511 : Xie, Aszterbaum, Zhang, Bonifas, Zachary, Epstein, McCormick: A role of PDGFRalpha in basal cell carcinoma proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 references for ABIN667511

More Proteins for PDGFRA Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. PDGFR alpha has an important role in cranial neural crest cell mitosis within the mandibular processes

  2. PDGF (show PDGFA Proteins) signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.

  3. PDGFRalpha has a role in demarcating the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

  4. In KIT-mutant GIST, inhibition of PDGFRA disrupts a KIT-ERK (show EPHB2 Proteins)-ETV1 (show ETV1 Proteins)-KIT signaling loop by inhibiting ERK (show EPHB2 Proteins) activation.

  5. Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase (show YES1 Proteins).

  6. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF (show PDGFA Proteins)/PDGFR (show PDGFRB Proteins) signaling activation.

  7. Data indicate that PDGF (show PDGFA Proteins)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins))-smad (show SMAD1 Proteins) proteins smad1 (show SMAD1 Proteins)/5/8 activation requires lysosome-mediated degradation of PDGF (show PDGFA Proteins) alpha Receptor (PDGFRalpha).

  8. PDGFR (show PDGFRB Proteins) is a key contributor to pulmonary vascular remodeling in experimental pulmonary hypertension.

  9. Multipotential Neural precursors deficient in arylsulfatase A (show ARSA Proteins) show a higher ratio of long versus short fatty acid sulfatides, reduction in PDGFRa, decreased AKT (show AKT1 Proteins) phosphorylation, and increased exosomal shedding of PDGFRa.

  10. purines activate SK currents via mainly P2Y1 (show P2RY1 Proteins) receptors in PDGFRalpha(+) cells

Human Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. we retrospectively examined correlations between clinical outcomes and KIT/PDGFRA mutational status in a subset of imatinib-resistant or -intolerant patients with stromal tumor participating in a worldwide, open-label treatment-use study

  2. Data characterized metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) genetic susceptibility genes beyond kit proto-oncogene (show RAB1A Proteins) protein (KIT)/PDGF (show PDGFA Proteins) alpha receptor (PDGFRalpha) genotype.

  3. Our data support those recently published in a meta-analysis on 1487 patients proving that GISTs bearing KIT mutations have a significantly poorer prognosis than either PDGFRA mutated or WT GISTs

  4. Case Report: rectal gastrointestinal stromal tumor with kit and PDGFRA mutations.

  5. 16.0% of the gastrointestinal stromal tumors samples studied had a mutation in PDGFRA

  6. case Report/Review: therapy-related acute myeloid leukemia (show BCL11A Proteins) with t(4:14)(q12;q24) and PDGFRA gene rearrangement.

  7. Case Report/Review: PDGFRA exon 18 mutation in myxoid epithelioid gastrointestinal stromal tumor.

  8. In conclusion, mutations in the PDGFRa gene was independent of the viral positivity and may represent an independent factor in Merkel cell carcinoma development.

  9. There were statistically significant correlations between the expression of PDGFR-alpha, c-Met, and EGFR (show EGFR Proteins) and disease-free survival

  10. The current study identified novel KIT and PDGFRA gene mutations that added new insights into the genetic heterogeneity of gastrointestinal stromal tumors

PDGFRA Protein Profile

Protein Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

Alternative names and synonyms associated with PDGFRA

  • platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
  • platelet-derived growth factor receptor, alpha polypeptide (LOC100218386)
  • platelet derived growth factor receptor, alpha polypeptide (Pdgfra)
  • platelet derived growth factor receptor, alpha polypeptide (pdgfra)
  • platelet-derived growth factor receptor alpha (LOC100343006)
  • AI115593 protein
  • APDGFR protein
  • CD140A protein
  • PDGFACE protein
  • PDGFR protein
  • PDGFR-2 protein
  • PDGFR-A protein
  • PDGFR2 protein
  • RHEPDGFRA protein

Protein level used designations for PDGFRA

platelet-derived growth factor receptor, alpha polypeptide , alpha-type platelet-derived growth factor receptor-like , Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) , CD140 antigen-like family member A , PDGF alpha chain , PDGF-R-alpha , PDGFR-alpha , alpha-type platelet-derived growth factor receptor , platelet-derived growth factor alpha receptor , platelet-derived growth factor receptor alpha , alpha platelet-derived growth factor receptor , CD140a antigen , PDGFRA/BCR fusion , platelet-derived growth factor receptor 2 , rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein , tyrosine kinase PDGFR

GENE ID SPECIES
100059815 Equus caballus
100218386 Taeniopygia guttata
100412331 Callithrix jacchus
100431735 Pongo abelii
100464991 Ailuropoda melanoleuca
18595 Mus musculus
25267 Rattus norvegicus
380245 Xenopus laevis
100343006 Oryctolagus cuniculus
5156 Homo sapiens
442860 Canis lupus familiaris
407607 Sus scrofa
282301 Bos taurus
395509 Gallus gallus
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