Browse our PDGFRA Proteins (PDGFRA)

Full name:
Platelet-Derived Growth Factor Receptor, alpha Polypeptide Proteins (PDGFRA)
On www.antibodies-online.com are 38 Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Proteins from 11 different suppliers available. Additionally we are shipping PDGFRA Antibodies (558) and PDGFRA Kits (58) and many more products for this protein. A total of 683 PDGFRA products are currently listed.
Synonyms:
AI115593, APDGFR, CD140A, PDGFACE, PDGFR, PDGFR-2, PDGFR-A, PDGFR2, RHEPDGFRA
list all proteins Gene Name GeneID UniProt
PDGFRA 18595 P26618
PDGFRA 25267 P20786
PDGFRA 5156 P16234

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PDGFRA Proteins (PDGFRA) by Origin

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Top referenced PDGFRA Proteins

  1. Human PDGFRA Protein expressed in Human Cells - ABIN2003042 : Matsui, Heidaran, Miki, Popescu, La Rochelle, Kraus, Pierce, Aaronson: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. in Science (New York, N.Y.) 1989 (PubMed)
    Show all 3 references for 2003042

  2. Human PDGFRA Protein expressed in Escherichia coli (E. coli) - ABIN667511 : Xie, Aszterbaum, Zhang, Bonifas, Zachary, Epstein, McCormick: A role of PDGFRalpha in basal cell carcinoma proliferation. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 2 references for 667511

  3. Rat (Rattus) PDGFRA Protein expressed in Human Cells - ABIN2009618 : Choudhury, Grandaliano, Jin, Katz, Abboud: Activation of PLC and PI 3 kinase by PDGF receptor alpha is not sufficient for mitogenesis and migration in mesangial cells. in Kidney international 2000 (PubMed)
    Show all 2 references for 2009618

More Proteins for PDGFRA Interaction Partners

Mouse (Murine) Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. FOXA3 (show FOXA3 Proteins) is a marker of the Sertoli cell lineage and of the adult Leydig cell population, and is a regulator of Pdgfra transcription in Leydig cells.

  2. PDGFRalpha and PDGFRbeta are coexpressed in the craniofacial mesenchyme of mid-gestation mouse embryos and that ablation of Pdgfrb (show PDGFRB Proteins) in the neural crest lineage results in increased nasal septum width, delayed palatal shelf development, and subepidermal blebbing.

  3. The results from this study indicate that PDGF (show PDGFA Proteins) signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.

  4. transient middle cerebral-arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb (show PDGFRB Proteins)-gene inactivation, including N-PRbeta-KO mice where the Pdgfrb (show PDGFRB Proteins)-gene was mostly inactivated in the brain except that in vascular pericytes

  5. PDGFR alpha has an important role in cranial neural crest cell mitosis within the mandibular processes

  6. PDGF (show PDGFA Proteins) signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.

  7. PDGFRalpha has a role in demarcating the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium

  8. In KIT-mutant GIST, inhibition of PDGFRA disrupts a KIT-ERK (show EPHB2 Proteins)-ETV1 (show ETV1 Proteins)-KIT signaling loop by inhibiting ERK (show EPHB2 Proteins) activation.

  9. Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase (show YES1 Proteins).

  10. Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF (show PDGFA Proteins)/PDGFR (show PDGFRB Proteins) signaling activation.

Human Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) interaction partners

  1. Data indicate that co-inhibition of FGFR1 (show FGFR1 Proteins) and HER2 (show ERBB2 Proteins) or PDGFRalpha led to enhanced drug responses.

  2. High PDGFRA expression is associated with pathogenesis of malignant peripheral nerve sheath tumor.

  3. The interaction between CSR1 (show SCARA3 Proteins) and SF3A3 (show SF3A3 Proteins) led to migration of SF3A3 (show SF3A3 Proteins) from nucleus to cytoplasm. The cytoplasmic redistribution of SF3A3 (show SF3A3 Proteins) significantly reduced the splicing efficiency of epidermal growth factor receptor (show EGFR Proteins) and platelet-derived growth factor receptor (show PDGFRL Proteins).

  4. PDGFRa amplification in multiple skin lesions of undifferentiated pleomorphic sarcoma

  5. PDGFRA mutations were associated with gastrointestinal stromal tumors.

  6. The PDGFRA kinase domain structure we report in this study has potential to facilitate development of new agents which can inhibit this kinase, including both its activating and drug-resistant mutations.

  7. BRAF (show BRAF Proteins) mutations are rare events in KIT/PDGFRA wild-type gastrointestinal stromal tumors.

  8. There are two platelet-derived growth factor receptor (PDGFR (show PDGFRB Proteins)) genes (PDGFRA and PDGFRB (show PDGFRB Proteins)), and they reside on chromosome 4 and 5.

  9. Data did not detect any significant association with SNPs of APRIL, SPATA8, PDGFRA, and POLB with Systemic Lupus Erythematosus in Chinese Han Population.

  10. Synchronous T lymphoblastic lymphoma and myeloid neoplasm with PDGFRA rearrangement.

PDGFRA Protein Profile

Protein Summary

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.

Alternative names and synonyms associated with PDGFRA

  • platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
  • platelet-derived growth factor receptor, alpha polypeptide (LOC100218386)
  • platelet derived growth factor receptor, alpha polypeptide (Pdgfra)
  • platelet derived growth factor receptor, alpha polypeptide (pdgfra)
  • platelet-derived growth factor receptor alpha (LOC100343006)
  • AI115593 protein
  • APDGFR protein
  • CD140A protein
  • PDGFACE protein
  • PDGFR protein
  • PDGFR-2 protein
  • PDGFR-A protein
  • PDGFR2 protein
  • RHEPDGFRA protein

Protein level used designations for PDGFRA

platelet-derived growth factor receptor, alpha polypeptide , alpha-type platelet-derived growth factor receptor-like , Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha) , CD140 antigen-like family member A , PDGF alpha chain , PDGF-R-alpha , PDGFR-alpha , alpha-type platelet-derived growth factor receptor , platelet-derived growth factor alpha receptor , platelet-derived growth factor receptor alpha , alpha platelet-derived growth factor receptor , CD140a antigen , PDGFRA/BCR fusion , platelet-derived growth factor receptor 2 , rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein , tyrosine kinase PDGFR

GENE ID SPECIES
100059815 Equus caballus
100218386 Taeniopygia guttata
100412331 Callithrix jacchus
100431735 Pongo abelii
100464991 Ailuropoda melanoleuca
18595 Mus musculus
25267 Rattus norvegicus
380245 Xenopus laevis
100343006 Oryctolagus cuniculus
5156 Homo sapiens
442860 Canis lupus familiaris
407607 Sus scrofa
282301 Bos taurus
395509 Gallus gallus
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