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On these bases, we identified that miR (show MLXIP ELISA Kits)-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR (show MLXIP ELISA Kits)-208b can regulate the development of osteosarcoma.
Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt (show WNT2 ELISA Kits) signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer.
Knockdown of Ror2 expression in renal cell carcinoma cells significantly reduced cell proliferation and induced apoptosis.
found no association between ROR2 staining and poor patient survival
Data show that CD13 (show ANPEP ELISA Kits) anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart.
ROR2 gene mutations are associated with autosomal recessive robinow syndrome.
results corroborated previous findings of Ryk (show RYK ELISA Kits)-mediated Wnt5a (show WNT5A ELISA Kits) effect, and suggested a role for Ror2 in the Wnt5a (show WNT5A ELISA Kits) machinery in glioblastoma
Data show that silencing receptor tyrosine kinases (RTKs) ROR2 and ROR1 (show ROR1 ELISA Kits) has a strong inhibitory effect on the ability of ovarian cancer cells to proliferate, migrate and invade.
Wnt5a (show WNT5A ELISA Kits)-Ror2 signaling enhances expression and secretion of CXCL16 (show CXCL16 ELISA Kits) in mesenchymal stem cells thereby activating CXCR6 (show CXCR6 ELISA Kits) expressed on tumor cells to promote proliferation.
the b-catenin-independent WNT (show WNT2 ELISA Kits) score correlated with reduced overall survival only in the metastasized situation . This is in line with the in vitro results of the alternative WNT (show WNT2 ELISA Kits) receptors ROR1 (show ROR1 ELISA Kits) and ROR2, which foster invasion
Although Ror1 (show ROR1 ELISA Kits)-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1 (show ROR1 ELISA Kits); Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
The Wnt5a (show WNT5A ELISA Kits)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (show IFNG ELISA Kits) in colitis
Non-canonical Wnt5a (show WNT5A ELISA Kits)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (show WNT5A ELISA Kits)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (show ITK ELISA Kits)) may play an important role in disrupting TBM via MMP-2 (show MMP2 ELISA Kits) induction during renal fibrosis.
The results indicate an important role of Wnt5a (show WNT5A ELISA Kits)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
This study provides a method to investigate the effects of the Wnt (show WNT2 ELISA Kits) pathway on the fate of mesenchymal stem cells (MSC (show MSC ELISA Kits)) in vivo and for the further improvement of MSC (show MSC ELISA Kits)-based therapies.
Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src (show SRC ELISA Kits)-dependent manner that is negatively regulated by NRAGE (show MAGED1 ELISA Kits).
Wnt5a (show WNT5A ELISA Kits)-Ror1 (show ROR1 ELISA Kits) and Wnt5a (show WNT5A ELISA Kits)-Ror2 signaling pathways regulated neurogenesis in the developing neocortex.
A soluble form of Ror2 acted as a decoy receptor of Wnt5a (show WNT5A ELISA Kits) and abrogated bone destruction in mouse arthritis models
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, neurotrophic tyrosine kinase receptor-related 2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2