Browse our TRKB Proteins (NTRK2)

Full name:
Neurotrophic Tyrosine Kinase, Receptor, Type 2 Proteins (NTRK2)
On are 38 Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Proteins from 13 different suppliers available. Additionally we are shipping TRKB Antibodies (355) and TRKB Kits (50) and many more products for this protein. A total of 469 TRKB products are currently listed.
AI848316, C030027L06Rik, GP145-TrkB, ntrk2, RATTRKB1, si:ch211-220b11.1, Tkrb, Trk-B, TrkB, trkb-b, TRKB1, trkB2, xtrkb
list all proteins Gene Name GeneID UniProt
NTRK2 4915 Q16620
NTRK2 18212 P15209
NTRK2 25054 Q63604

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TRKB Proteins (NTRK2) by Origin

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Top referenced TRKB Proteins

  1. Dog (Canine) TRKB Protein expressed in Human Cells - ABIN2008876 : Pillai: Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia. in Neuro-Signals 2008 (PubMed)
    Show all 4 references for 2008876

  2. Rat (Rattus) TRKB Protein expressed in Human Cells - ABIN2009366 : Haniu, Montestruque, Bures, Talvenheimo, Toso, Lewis-Sandy, Welcher, Rohde: Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for 2009366

  3. Dog (Canine) TRKB Protein expressed in Human Cells - ABIN2008878 : Haapasalo, Sipola, Larsson, Akerman, Stoilov, Stamm, Wong, Castren: Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for 2008878

  4. Human TRKB Protein expressed in Human Cells - ABIN2001961 : Geiger, Peeper: Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. in Cancer research 2007 (PubMed)
    Show all 4 references for 2001961

  5. Human TRKB Protein expressed in HEK-293 Cells - ABIN2181555 : Allen, Dawbarn, Eckford, Wilcock, Ashcroft, Colebrook, Feeney, MacGowan: Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. in Neuroscience 1994 (PubMed)
    Show all 4 references for 2181555

More Proteins for TRKB Interaction Partners

Zebrafish Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA (show NTRK1 Proteins) and TrkB-receptors in cells and fibers of granular and molecular layers. TrkC (show NTRK3 Proteins) was faintly detected

  2. BDNF (show BDNF Proteins)-TrkB influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

  3. Light regulates the expression of the BDNF (show BDNF Proteins)/TrkB2 system in the adult zebrafish retina.

Rhesus Monkey Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. Study showed that complex relationships exist between BDNF (show BDNF Proteins)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

Human Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. overexpression of TrkB, but not of BDNF (show BDNF Proteins), is significantly associated with a poor survival outcome for TNBC patients.

  2. In the current work, we provide a global analysis of the physiological consequences of TrkB receptor activation in vitro and discuss the dynamic consequences of TrkB activation in vivo. Finally, we propose a clinically-feasible option for increasing BDNF (show BDNF Proteins) expression in the hypothalamus to more readily utilize the oncolytic effects of BDNF (show BDNF Proteins).

  3. ShcD (show SHC4 Proteins) binds to active Ret (show RET Proteins), TrkA (show NTRK1 Proteins), and TrkB neurotrophic factor (show NTF3 Proteins) receptors predominantly via its phosphotyrosine-binding (PTB (show PTBP1 Proteins)) domain.

  4. These findings, while exploratory, indicate that the genotypes of NTRK2 and COMT (show COMT Proteins) may contribute to relative risk for symptom burden during and shortly after the period of chemotherapy in women with early stage breast cancer.

  5. We demonstrated that downregulation of PHLDA1 (show PHLDA1 Proteins) leads to a significant increase in expression of Aurora A (show AURKA Proteins) and TRKB that are markers of poor prognosis in neuroblastoma (show ARHGEF16 Proteins)

  6. The receptors, TrkB and p75 (show CUX1 Proteins) are more highly expressed in deep infiltrating endometriosis than in peritoneal tissues.

  7. High expression of NTRK2 is associated with gastric cancer.

  8. Genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.

  9. High expression of TrkA (show NTRK1 Proteins), TrkB, or TrkC (show NTRK3 Proteins) was significantly associated with histopathology

  10. Results show up-regulation of TrkB and down-regulation of Runx3 (show RUNX3 Proteins) and Keap1 (show KEAP1 Proteins) in breast cancer cells and suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (show RUNX3 Proteins) or Keap1 (show KEAP1 Proteins).

Mouse (Murine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. findings show that BDNF (show BDNF Proteins)-TrkB signaling, rather than Dopamine signaling, in the Ventral Tegmental Area -Nuc (show SREBF2 Proteins). Accumbens circuit is crucial for facilitating depressive-like depressive-like outcomes after Chronic Social Defeat Stress and they establish BDNF (show BDNF Proteins)-TrkB signaling as a pathologic mechanism during periods of chronic stress.

  2. inhibition of Sig (show PICALM Proteins)-1 R prevented cocaine-induced TrkB activation in hippocampal neurons.

  3. After spinal cord injury, astrocyte-specific TrkB knock-out mice showed reduced hyperpathic responses and improved motor coordination.

  4. Results imply that oleanolic acid ameliorates scopolamine-induced memory impairment by modulating the brain-derived neurotrophic factor (show BDNF Proteins) -ERK1/2-cAMP response element-binding protein pathway through tropomyosin receptor kinase (show NTRK1 Proteins) B activation in mice, suggesting that oleanolic acid would be a potential therapeutic agent for the treatment of cognitive deficits.

  5. Data show that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) participates in the migration of cortical neurons during cortical development by mediating TrkB receptor axonal anterograde transport.

  6. findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (show GRIN1 Proteins)-CaMKII (show CAMK2G Proteins)-dependent BDNF (show BDNF Proteins) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity

  7. Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.

  8. Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF (show BDNF Proteins)/TrkB and downstream neuroplastic signaling

  9. Observations provide evidence that female-specific induction of estrogen receptor alpha (show ESR1 Proteins) expression confers neuroprotection with TrkB agonist therapy via Src (show SRC Proteins) family kinase activation and account for improved functional outcomes in female neonates post-hypoxia and ischemia.

  10. data suggest antidepressant effects of BDNF (show BDNF Proteins)-TrkB in the NAc, which could not be explained by activation of the transcription factors CREB (show CREB1 Proteins) or beta-catenin (show CTNNB1 Proteins). The effects TrkB has on depression-related behavior in different brain regions appear to critically depend on the targeted cell type.

Cow (Bovine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF (show BDNF Proteins)) and its receptor (BDNF (show BDNF Proteins) receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).

  2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (show BDNF Proteins)-Trk-B

TRKB (NTRK2) Protein Profile

Protein Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRKB (NTRK2)

  • neurotrophic tyrosine kinase, receptor, type 2 (NTRK2)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-b)
  • neurotrophic tyrosine kinase, receptor, type 2b (ntrk2b)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-a)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2)
  • neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2)
  • AI848316 protein
  • C030027L06Rik protein
  • GP145-TrkB protein
  • ntrk2 protein
  • RATTRKB1 protein
  • si:ch211-220b11.1 protein
  • Tkrb protein
  • Trk-B protein
  • TrkB protein
  • trkb-b protein
  • TRKB1 protein
  • trkB2 protein
  • xtrkb protein

Protein level used designations for NTRK2

neurotrophin receptor B xTrkB-alpha , BDNF/NT-3 growth factors receptor , neurotrophic tyrosine kinase, receptor, type 2 , BDNF/NT-3 growth factors receptor-like , neurotrophic tyrosine kinase receptor type 2 , trk-B , trkB tyrosine kinase , tyrosine kinase receptor , BDNF-tropomyosine receptor kinase B , tropomyosin-related kinase B , tyrosine kinase receptor B , GP145-TrkB/GP95-TrkB , neural receptor protein-tyrosine kinase (trkB) , trkB protein

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