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Browse our TRKB Proteins (NTRK2)

Full name:
Neurotrophic Tyrosine Kinase, Receptor, Type 2 Proteins (NTRK2)
On are 34 Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) Proteins from 12 different suppliers available. Additionally we are shipping TRKB Antibodies (337) and TRKB Kits (43) and many more products for this protein. A total of 440 TRKB products are currently listed.
AI848316, C030027L06Rik, GP145-TrkB, ntrk2, RATTRKB1, si:ch211-220b11.1, Tkrb, Trk-B, TrkB, trkb-b, TRKB1, trkB2, xtrkb
list all proteins Gene Name GeneID UniProt
NTRK2 4915 Q16620
NTRK2 18212 P15209
NTRK2 25054 Q63604

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TRKB Proteins (NTRK2) by Origin

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Top referenced TRKB Proteins

  1. Dog (Canine) TRKB Protein expressed in Human Cells - ABIN2008876 : Pillai: Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia. in Neuro-Signals 2008 (PubMed)
    Show all 4 references for ABIN2008876

  2. Rat (Rattus) TRKB Protein expressed in Human Cells - ABIN2009366 : Haniu, Montestruque, Bures, Talvenheimo, Toso, Lewis-Sandy, Welcher, Rohde: Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for ABIN2009366

  3. Dog (Canine) TRKB Protein expressed in Human Cells - ABIN2008878 : Haapasalo, Sipola, Larsson, Akerman, Stoilov, Stamm, Wong, Castren: Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 references for ABIN2008878

  4. Human TRKB Protein expressed in HEK-293 Cells - ABIN2181553 : Allen, Dawbarn, Eckford, Wilcock, Ashcroft, Colebrook, Feeney, MacGowan: Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. in Neuroscience 1994 (PubMed)
    Show all 4 references for ABIN2181553

  5. Mouse (Murine) TRKB Protein expressed in Human Cells - ABIN2007380 : Geiger, Peeper: Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. in Cancer research 2007 (PubMed)
    Show all 4 references for ABIN2007380

More Proteins for TRKB Interaction Partners

Zebrafish Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. BDNF (show BDNF Proteins)-TrkB influences the expression level of components of chemokine (show CCL1 Proteins) signaling including Cxcr4b, and the generation of progenitors of mechanoreceptors, at the level of expression of Atoh1a-Atp2b1a.

  2. Light regulates the expression of the BDNF (show BDNF Proteins)/TrkB2 system in the adult zebrafish retina.

Rhesus Monkey Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. Study showed that complex relationships exist between BDNF (show BDNF Proteins)/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence

Human Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. High expression of NTRK2 is associated with gastric cancer.

  2. Genetic variability of NTRK2, a susceptibility gene for psychiatric disorders, is related to emotional arousal and-independently-to brain white-matter properties in healthy individuals.

  3. High expression of TrkA (show NTRK1 Proteins), TrkB, or TrkC (show NTRK3 Proteins) was significantly associated with histopathology

  4. Results show up-regulation of TrkB and down-regulation of Runx3 (show RUNX3 Proteins) and Keap1 (show KEAP1 Proteins) in breast cancer cells and suggest that TrkB plays a key role in tumorigenicity and metastasis of breast cancer cells through suppression of Runx3 (show RUNX3 Proteins) or Keap1 (show KEAP1 Proteins).

  5. Our data revealed that anoikis-resistant ACHN (show LARP6 Proteins) cells presented with tolerance to detachment-induced apoptosis, excessive proliferation and aggressive invasion, accompanied by upregulation of TrkB expression in contrast to parental cells

  6. results demonstrate the occurrence of ASIC2 (show ACCN1 Proteins) and TrkB in the human intervertebral disc (IVD (show IVD Proteins)), and the increased expression of both in pathological IVD (show IVD Proteins) suggest their involvement in IVD (show IVD Proteins) degeneration

  7. Data indicate the role of tropomyosin-related kinase-B (TrkB) in activation of the interleukin-6 (show IL6 Proteins)/Janus kinase 2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) transcription factor and PI3 kinase (show PIK3CA Proteins)/c-AKT (show AKT1 Proteins) proto-oncogene (show RAB1A Proteins) protein pathway in breast cancer.

  8. soluble Abeta42 and BDNF (show BDNF Proteins), but not TrkB or soluble tau, correlate with dementia in the oldest-old

  9. The rare variants in NTRK2 were significantly associated with smoking status.

  10. Entrectinib inhibits growth of TrkB expressing neuroblastoma (show ARHGEF16 Proteins) cells in vitro and in vivo, and that it enhances the efficacy of conventional chemotherapy in in vivo models.

Mouse (Murine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. findings reveal a spine-autonomous, autocrine signalling mechanism involving NMDAR (show GRIN1 Proteins)-CaMKII (show CAMK2G Proteins)-dependent BDNF (show BDNF Proteins) release from stimulated dendritic spines and subsequent TrkB activation on these same spines that is crucial for structural and functional plasticity

  2. Following ethanol administration, phosphorylation of TrkB in the striatum was significantly reduced in wild-type mice.

  3. Results suggest that the therapeutic actions of atypical antidepressant drugs involve various neurocircuits, some of which, but not all, appears to involve BDNF (show BDNF Proteins)/TrkB and downstream neuroplastic signaling

  4. Observations provide evidence that female-specific induction of estrogen receptor alpha (show ESR1 Proteins) expression confers neuroprotection with TrkB agonist therapy via Src (show SRC Proteins) family kinase activation and account for improved functional outcomes in female neonates post-hypoxia and ischemia.

  5. data suggest antidepressant effects of BDNF (show BDNF Proteins)-TrkB in the NAc, which could not be explained by activation of the transcription factors CREB (show CREB1 Proteins) or beta-catenin (show CTNNB1 Proteins). The effects TrkB has on depression-related behavior in different brain regions appear to critically depend on the targeted cell type.

  6. Study indicates that diminished mature BDNF (show BDNF Proteins) trophic signaling through the TrkB receptor, rather than an induction in proBDNF, is a main contributing factor to the vulnerability of striatal neurons in the zQ175 HD mouse model

  7. TrkB is an endothelial injury-response molecule in atherogenesis. Endothelial brain-derived neurotrophic factor (show BDNF Proteins)/TrkB signaling reduces VE-cadherin (show CDH5 Proteins) shedding and protects against atherosclerotic lesion development in ApoE (show APOE Proteins)-/- mice.

  8. Brain ischaemia induces shedding of a BDNF (show BDNF Proteins)-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and gamma-secretases.

  9. Brain-derived neurotrophic factor (BDNF (show BDNF Proteins)) and its specific receptor, tropomyosin (show TPM2 Proteins)-related kinase (TrkB), have a role the in pathophysiology of depression.

  10. Expression of the dominant-negative BDNF (show BDNF Proteins) receptor TrkB receptor in the majority of pyramidal neurons in adult visual cortex has strikingly different effects on cortical wiring than expression of the same transgene in a sparse neuron population.

Cow (Bovine) Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2) interaction partners

  1. These observations provided evidence that brain-derived naeurotrophic factor(BDNF (show BDNF Proteins)) and its receptor (BDNF (show BDNF Proteins) receptor) secreted by bovine sperm was important in regulation of insulin (show INS Proteins) and leptin (show LEP Proteins).

  2. Expressed in ganglionic neuron-like tumor cells, which may activate an embryonic autocrine pathwy involving bdnf (show BDNF Proteins)-Trk-B

TRKB (NTRK2) Protein Profile

Protein Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRKB (NTRK2)

  • neurotrophic tyrosine kinase, receptor, type 2 (NTRK2)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-b)
  • neurotrophic tyrosine kinase, receptor, type 2b (ntrk2b)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2-a)
  • neurotrophic tyrosine kinase, receptor, type 2 (ntrk2)
  • neurotrophic tyrosine kinase, receptor, type 2 (Ntrk2)
  • AI848316 protein
  • C030027L06Rik protein
  • GP145-TrkB protein
  • ntrk2 protein
  • RATTRKB1 protein
  • si:ch211-220b11.1 protein
  • Tkrb protein
  • Trk-B protein
  • TrkB protein
  • trkb-b protein
  • TRKB1 protein
  • trkB2 protein
  • xtrkb protein

Protein level used designations for NTRK2

neurotrophin receptor B xTrkB-alpha , BDNF/NT-3 growth factors receptor , neurotrophic tyrosine kinase, receptor, type 2 , BDNF/NT-3 growth factors receptor-like , neurotrophic tyrosine kinase receptor type 2 , trk-B , trkB tyrosine kinase , tyrosine kinase receptor , BDNF-tropomyosine receptor kinase B , tropomyosin-related kinase B , tyrosine kinase receptor B , GP145-TrkB/GP95-TrkB , neural receptor protein-tyrosine kinase (trkB) , trkB protein

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