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anti-Human WASF3 Antibodies:
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Chicken Polyclonal WASF3 Primary Antibody for WB - ABIN2784832
Sossey-Alaoui, Li, Cowell: c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration. in The Journal of biological chemistry 2007
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (show WASF1 Antibodies) and -3 to the metastatic phenotype of PC-3 (show PCSK1 Antibodies) cells through their interaction with the ARP2 (show ACTR2 Antibodies)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (show ATAD3A Antibodies) and GRP78 (show HSPA5 Antibodies), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (show NFKB1 Antibodies) is required for invadopodia formation as well as MMP9 (show MMP9 Antibodies) expression and activity that are needed for cancer cells to degrade the ECM (show MMRN1 Antibodies)
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail (show SNAI1 Antibodies).
miR (show MLXIP Antibodies)-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3.
Upregulated WAVE3 expression is essential for TGF-beta (show TGFB1 Antibodies)-mediated EMT (show ITK Antibodies) and metastasis of triple-negative breast cancer cells.
ZEB1 (show ZEB1 Antibodies)/2 upregulation by WASF3 results from downregulation of KISS1 (show KISS1 Antibodies), leading to the release of inhibition of nuclear factor (NF)kappaB (show NFKB1 Antibodies) by IkappaBalpha (show NFKBIA Antibodies)
these results define a novel signaling network whereby JAK2 (show JAK2 Antibodies)/STAT3 (show STAT3 Antibodies) signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility.
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3