Browse our WIPF1 Proteins (WIPF1)

Full name:
WAS/WASL Interacting Protein Family, Member 1 Proteins (WIPF1)
On are 5 WAS/WASL Interacting Protein Family, Member 1 (WIPF1) Proteins from 4 different suppliers available. Additionally we are shipping WIPF1 Antibodies (36) and many more products for this protein. A total of 47 WIPF1 products are currently listed.
AI115543, D2Ertd120e, PRPL-2, Waspip, Wip
list all proteins Gene Name GeneID UniProt
WIPF1 7456 O43516
Mouse WIPF1 WIPF1 215280 Q8K1I7
WIPF1 117538 Q6IN36

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WIPF1 Proteins (WIPF1) by Origin

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Human WAS/WASL Interacting Protein Family, Member 1 (WIPF1) interaction partners

  1. Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics.

  2. establish a new cancer stem cell signalling pathway downstream of mtp53 in which AKT2 (show AKT2 Proteins) regulates WIP and controls YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) stability.

  3. Knocking down WIP expression in A549 cells significantly reduced RhoA (show RHOA Proteins) levels and WIP was found to interact with RhoA (show RHOA Proteins) suggesting that WIP might be executing its function by regulating RhoA (show RHOA Proteins).

  4. Study provides evidence that WIP and WIRE contribute to breast cancer cell invasiveness through coordinated roles. WIP seems necessary for the assembly of invasive protrusions, whereas WIRE regulates their maturation, which leads to matrix degradation.

  5. conclude that tyrosine phosphorylation of WIP is a crucial regulator of WASP stability and function as an actin-nucleation-promoting factor

  6. WIP was shown to interact with various binding partners, including the signaling proteins Nck (show NCK1 Proteins), CrkL (show CRKL Proteins) and cortactin (show CTTN Proteins).

  7. Data indicate the WASp-interacting protein (WIP)-Wiskott-Aldrich syndrome protein (WASp) interaction in the regulation of actin-dependent processes.

  8. These findings reveal WIP as a previously unreported regulator of neuronal maturation and synaptic activity

  9. These findings indicate that WIP deficiency should be suspected in patients with features of WAS in whom WAS sequence and mRNA levels are normal.

  10. The results suggest that some of the mutations in the WH1 domain cause the Wiskott-Aldrich syndrome syndrome in humans by perturbing the WASP-WIP complex formation.

Mouse (Murine) WAS/WASL Interacting Protein Family, Member 1 (WIPF1) interaction partners

  1. These experiments identify WIP as a member of a signaling cascade comprised of Abl (show ABL1 Proteins) family kinases, mTORC1 and S6K (show RPS6KB1 Proteins), which regulates neuron development and specifically, neuritic branching and complexity.

  2. WIP is a link between membrane lipid composition and actin cytoskeleton at dendritic spines.

  3. WIPf1 deficiency results in defective B cell function. By regulating the cortical actin cytoskeleton, WIPf1 influences the function of CD19 (show CD19 Proteins) as a general hub for PI3K signaling.

  4. WIP binding to actin, independently of its binding to Wiskott-Aldrich syndrome protein, is critical for the integrity of the actin cytoskeleton in T cells and for their migration into tissues.

  5. Results show that WIP is a novel regulator of focal adhesion assembly and cell adhesion.

  6. Data indicate the involvement of WIP (WASP Interacting Protein) in the control of migratory persistence in both mesenchymal (fibroblast) and amoeboid (B lymphocytes) motility.

  7. Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly.

  8. These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly.

  9. This study implicates WIP in enteropathogenic Escherichia coli-mediated actin polymerization and pedestal elongation.

  10. These findings identify a novel role for mAbp1 in growth factor-induced dorsal ruffle formation through its interaction with WIP.

WIPF1 Protein Profile

Protein Summary

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.

Alternative names and synonyms associated with WIPF1

  • WAS/WASL interacting protein family, member 1 (WIPF1)
  • WAS/WASL interacting protein family, member 1 (Wipf1)
  • AI115543 protein
  • D2Ertd120e protein
  • PRPL-2 protein
  • Waspip protein
  • Wip protein

Protein level used designations for WIPF1

WAS/WASL interacting protein family, member 1 , WAS/WASL-interacting protein family member 1 , Wiskott-Aldrich syndrome protein interacting protein , WASP interacting protein , WASP-interacting protein , protein PRPL-2 , wiskott-Aldrich syndrome protein-interacting protein

459755 Pan troglodytes
698446 Macaca mulatta
424143 Gallus gallus
540304 Bos taurus
100580744 Nomascus leucogenys
7456 Homo sapiens
215280 Mus musculus
117538 Rattus norvegicus
488409 Canis lupus familiaris
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