Browse our Myosin VI Proteins (MYO6)

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Myosin VI Proteins (MYO6)
On are 4 Myosin VI (MYO6) Proteins from 3 different suppliers available. Additionally we are shipping Myosin VI Antibodies (45) and many more products for this protein. A total of 53 Myosin VI products are currently listed.
95F, 95F MHC, BC029719, CG5695, CMY6, DFNA22, DFNB37, Dm95F, Dm 95F, Dmel\\CG5695, Dro95F, jag, Jaguar, Jar, M6, Mhc95F, ms(3)06746, myosins VI, Myosin VI, MyoVI, RGD1560646, sv, Tlc
list all proteins Gene Name GeneID UniProt
MYO6 4646 Q9UM54
MYO6 17920  
Rat MYO6 MYO6 315840  

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Myosin VI Proteins (MYO6) by Origin

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More Proteins for Myosin VI Interaction Partners

Fruit Fly (Drosophila melanogaster) Myosin VI (MYO6) interaction partners

  1. These observations support the notion that a major function of Myosin VI in the nerve terminal is tethering synaptic vesicles to proper sub-cellular location within the bouton

  2. These data demonstrate that generating an organized and functional actin (show ACTB Proteins) structure in this cell requires multiple activities coordinated by myosin VI.

  3. The androcam structure and its binding to the myosin VI structural (Insert 2) and regulatory (IQ) light chain sites are distinct from those of calmodulin (show CALM Proteins).

  4. data indicate that myosin V (show MYO5A Proteins) and VI, but not II, play related but distinct roles in regulating microtubule (MT)-based mitochondrial movement: they oppose, rather than complement, protracted MT-based movements and perhaps facilitate organelle docking

  5. MyoVI is required for border cell migration where it stabilizes E-cadherin (show CDH1 Proteins) and Arm.

  6. Myosin VI is crucial for correct cell morphology and maintenance of adhesive cellular contacts within epithelial cell layers.

  7. Myosin VI stabilizes a branched actin network in actin structures (cones) that mediate the separation of the syncytial spermatids. I

  8. The spatial and temporal expression of Myosin VI was examined by expressing a Green Fluorescent Protein tagged Myosin VI molecule, under the control of a Myosin VI-Gal4 (show LGALS4 Proteins) line.

  9. Data suggest that Echinoid mediates the dimerization of myosin VI/Jaguar in vivo which in turn regulates the reorganization and/or contraction of actin (show ACTB Proteins) filaments to control changes in cell shape.

  10. Miranda protein forms an apical crescent at interphase, but is ubiquitously localized at prophase in a Myosin-II-dependent manner.

Human Myosin VI (MYO6) interaction partners

  1. MYO6 could play an essential role in the growth of OSCC cells via regulation of cell cycle progression and apoptosis.

  2. characterisation of the human myosin VI deafness mutant (R1166X) suggests that defects in cargo binding may leave myosin VI in a primed/activated state with an increased actin-binding ability

  3. PRAS40 (show AKT1S1 Proteins) was downregulated in the DU145 cells following MYO6 knockdown.

  4. knockdown of MYO6 slightly arrested cell cycle in G0/G1 phase, but remarkably increased the proportion of the sub-G1 phase of cell with the increase of apoptotic cells in colorectal cancer

  5. study indicates that MYO6 may play an important role in gastric cancer tumorigenesis and may serve as a potential therapeutic target in human gastric cancer.

  6. This study identified an isoform-specific regulatory helix, named the alpha2-linker, that defines specific conformations and hence determines the target selectivity of human myosin VI.

  7. Interaction of myosin VI and its binding partner DOCK7 plays an important role in NGF-stimulated protrusion formation in PC12 cells.

  8. Knockdown of myosin VI significantly suppressed melanoma cell viability and proliferation.

  9. Knockdown of MYO6 markedly reduced cell viability and colony formation, as well as suppressed cell cycle progression in breast cancer cells.

  10. MYO6 was highly expressed in hepatocellular carcinoma.

Mouse (Murine) Myosin VI (MYO6) interaction partners

  1. We propose that myosin VI, by removing stereociliary elements such as CDH23 (show CDH23 Proteins) as a component of the transient lateral links (which are probably required for the integrity of the immature hair bundles), allows the hair bundle and its transduction apparatus to progress in their development, so that the mechano-electrical transducer channels acquire their physiological resting tension and Ca2 (show CA2 Proteins)+-dependent adaptation properties

  2. a plaque accretion defect as the primary manifestation of myosin VI loss in Cx43 (show GJA1 Proteins) homeostasis, is reported.

  3. the Turner mutation was mapped to a critical region of 11 cM on chromosome 9 that includes myosin VI.

  4. Myo1a (show MYO1A Proteins) and Myo6 play essential roles in response to intestinal mucosal injury

  5. Disruption in optineurin (show OPTN Proteins) and myosin VI-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  6. We postulate that this novel interaction linking MVI with the PKA pathway could be important for targeting AKAP9-PKA complex within cells and/or providing PKA to phosphorylate MVI tail domain.

  7. Dysfunction of myosin VI is associated with slow retinal optic neuropathy and age-related macular degeneration.

  8. homologous pairing and myosin VI-mediated transcriptional pause release account for the rapid and efficient expression of genes induced by an external stimulus

  9. Myosin VI mediates the movement of NHE3 (show SLC9A3 Proteins) to the microvillus in intestinal epithelial cells.

  10. Report no change in cardiac myosin VI expression in mouse model of dilated cardiomyopathy.

Pig (Porcine) Myosin VI (MYO6) interaction partners

  1. Data suggest that cells direct the movement of vesicles around a cell by altering the relative number of myosin Va (show MYO5A Proteins) from Gallus gallus and myosin VI from Sus scrofa.

  2. A myosin VI deafness mutation, D179Y, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and destroyed the ability of single dimeric molecules to move processively on actin filaments.

  3. model reveals that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling mode

  4. The stepping dynamics of single quantum-dot-labeled myoV and myoVI motors linked to a common cargo, was studied.

  5. These results suggest that myosin VI kinetics are tuned such that the motor maintains a consistent level of mechanical tension within the cell, a property potentially shared by other mechanosensitive proteins.

  6. a mechanism is proposed of myosin VI stepping that predicts a regulation through load of the motor's roles as transporter and anchor

  7. 2.4-A structure of a truncated version of the reverse-direction myosin motor, myosin VI, that contains the motor domain and binding sites for two calmodulin (show CALM Proteins) molecules

  8. Data demonstrate that full-length myosin VI is capable of forming stable, processive dimers when monomers are clustered, which move up to 1-2 mum in approximately 30 nm, hand-over-hand steps.

  9. further adaptations within the motor increase the magnitude and variability of the plus-end directed converter movements, and unexpectedly provide the source of the highly variable myosin VI step size

  10. Results suggest that myosin VI and vinculin (show VCL Proteins) form a molecular apparatus that generates cohesive cell-cell contacts in cultured mammalian epithelia.

Cow (Bovine) Myosin VI (MYO6) interaction partners

  1. MVI, but not myosins IB or IIB, was detected in chromaffin granules isolated from bovine medulla and found to be tightly associated with the granule apical surface.

Myosin VI (MYO6) Protein Profile

Protein Summary

This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.

Alternative names and synonyms associated with Myosin VI (MYO6)

  • jaguar (jar)
  • myosin VI (LOC373230)
  • myosin VI (LOC100223124)
  • myosin VI (LOC100351334)
  • myosin VI (myo6)
  • myosin VI (MYO6)
  • myosin VI (Myo6)
  • 95F protein
  • 95F MHC protein
  • BC029719 protein
  • CG5695 protein
  • CMY6 protein
  • DFNA22 protein
  • DFNB37 protein
  • Dm95F protein
  • Dm 95F protein
  • Dmel\\CG5695 protein
  • Dro95F protein
  • jag protein
  • Jaguar protein
  • Jar protein
  • M6 protein
  • Mhc95F protein
  • ms(3)06746 protein
  • myosins VI protein
  • Myosin VI protein
  • MyoVI protein
  • RGD1560646 protein
  • sv protein
  • Tlc protein

Protein level used designations for Myosin VI Proteins (MYO6)

95F myosin , 95F unconventional myosin , CG5695-PB , CG5695-PG , CG5695-PH , CG5695-PI , CG5695-PJ , CG5695-PK , CG5695-PL , CG5695-PM , jar-PB , jar-PG , jar-PH , jar-PI , jar-PJ , jar-PK , jar-PL , jar-PM , myosin 95F , myosin VI , myosin heavy chain , myosin heavy chain at 95F , myosin-VI , unconventional myosin VI , unconventional myosin-6 , unconventional myosin-VI , Snell's waltzer , tailchaser , unconventional myosin

42889 Drosophila melanogaster
373230 Strongylocentrotus purpuratus
100223124 Taeniopygia guttata
100351334 Oryctolagus cuniculus
100554995 Anolis carolinensis
100588526 Nomascus leucogenys
4646 Homo sapiens
17920 Mus musculus
315840 Rattus norvegicus
395487 Gallus gallus
397085 Sus scrofa
481884 Canis lupus familiaris
535127 Bos taurus
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