Browse our PCDH15 Proteins (PCDH15)

Full name:
Protocadherin-15 Proteins (PCDH15)
On www.antibodies-online.com are 5 Protocadherin-15 (PCDH15) Proteins from 2 different suppliers available. Additionally we are shipping PCDH15 Kits (19) and PCDH15 Antibodies (15) and many more products for this protein. A total of 41 PCDH15 products are currently listed.
Synonyms:
av, BB078305, CDHR15, DFNB23, ENSMUSG00000046980, Gm9815, nmf19, protocadherin-15, USH1F
list all proteins Gene Name GeneID UniProt
PCDH15 11994 Q99PJ1
Rat PCDH15 PCDH15 690865  
PCDH15 65217 Q96QU1

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PCDH15 Proteins (PCDH15) by Origin

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More Proteins for PCDH15 Interaction Partners

Mouse (Murine) Protocadherin-15 (PCDH15) interaction partners

  1. Through an interaction with PIST (show GOPC Proteins), PCDH15 is retained in the trans-Golgi network and its expression is reduced in the plasma membrane.

  2. Absence of Pcdh15-CD2 isoform results in the loss of tip-links in mature auditory hair cells.

  3. Pcdh15 as a determinant of SERT (show SLC6A4 Proteins) protein expression and 5-HT (show DDC Proteins) homeostasis.

  4. the involvement of the gene Pcdh15 in auditory function

  5. These results offer new insights into the interaction between PCDH15 and CDH23 and help explain the etiology of human deafness linked to mutations in the tip-link interface.

  6. crystallography, molecular dynamics simulations and binding experiments to characterize the protocadherin 15-cadherin 23 bond

  7. Pcdh15 variants colocalize with rab5 (show RAB5A Proteins) and traffic apically to the hair cell bundle.

  8. A novel synaptic Usher complex comprised of clarin-1 and specific isoforms of CDH23, PCDH15 and VLGR1, was identified.

  9. results therefore provide genetic evidence consistent with PCDH15 and CDH23 being part of the tip-link complex and necessary for normal mechanotransduction

  10. Findings reveal an essential role for PCDH15-CD2 (show CCND2 Proteins) in the formation of kinociliary links and hair bundle polarization, and show that several PCDH15 isoforms can function redundantly at tip links.

Human Protocadherin-15 (PCDH15) interaction partners

  1. PCDH15 polymorphism is associated with extraversion.

  2. Results present structures of a protocadherin-15 fragment featuring a non-canonical linker region that exhibits increased flexibility without compromising mechanical strength.

  3. This study confirms that genetic variations in PCDH15 modify the susceptibility to noise-induced hearing loss development in humans.

  4. Results uncovered a novel interaction between MYO3A (show MYO3A Proteins) and PCDH15 shedding new light on the function of myosin IIIA (show MYO3A Proteins) at stereocilia tips.

  5. no statistically significant association between any rare, heterozygous PCDH15 point variants and schizophrenia or autism spectrum disorders was found

  6. PCDH15 p.Asp1010Gly variant probably modified the phenotypic expression of the 7511T>C mutation in MT-TS1

  7. The novel homozygous mutation in a family segregating non-syndromic hearing loss family supports previous reported observations that PCDH15 does not only causes Usher syndrome type 1F, but also DFNB23.

  8. PCDH15 or DFNB59 (show DFNB59 Proteins) variants are associated with poor CI performance, yet children with PCDH15 or DFNB59 (show DFNB59 Proteins) variants might show clinical features indistinguishable from those of other typical pediatric cochlear implant recipients.

  9. PCDH15 has several alternate cytoplasmic domain exons and differentially spliced isoforms may function redundantly

  10. Genetic variations of PCDH15 and their interactions with occupational noise exposure are associated with genetic susceptibility t onoise-induced hearing loss.

PCDH15 Protein Profile

Protein Summary

This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.

Alternative names and synonyms associated with PCDH15

  • protocadherin-15 (CpipJ_CPIJ005081)
  • protocadherin 15 (Pcdh15)
  • protocadherin 15 (LOC100356485)
  • protocadherin-15-like (LOC100862556)
  • protocadherin-related 15 (PCDH15)
  • protocadherin-related 15 (Pcdh15)
  • av protein
  • BB078305 protein
  • CDHR15 protein
  • DFNB23 protein
  • ENSMUSG00000046980 protein
  • Gm9815 protein
  • nmf19 protein
  • protocadherin-15 protein
  • USH1F protein

Protein level used designations for Protocadherin-15 Proteins (PCDH15)

protocadherin-15 , Ames waltzer , protocadherin 15 CD2 , protocadherin 15 CD3 isoform , cadherin-related family member 15 , protocadherin 15 , protocadherin-15-CD3

GENE ID SPECIES
6036517 Culex quinquefasciatus
11994 Mus musculus
690865 Rattus norvegicus
100356485 Oryctolagus cuniculus
100862556 Mus musculus
65217 Homo sapiens
100151991 Sus scrofa
423644 Gallus gallus
100718043 Cavia porcellus
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