Browse our CHAT Proteins (CHAT)

On are 4 Choline O-Acetyltransferase (CHAT) Proteins from 3 different suppliers available. Additionally we are shipping CHAT Antibodies (109) and CHAT Kits (40) and many more products for this protein. A total of 157 CHAT products are currently listed.
B230380D24Rik, ChoAcTase, CMS1A, CMS1A2
list all proteins Gene Name GeneID UniProt
CHAT 12647  
CHAT 1103 P28329
CHAT 290567  

CHAT Proteins (CHAT) by Origin

More Proteins for CHAT Interaction Partners

Mouse (Murine) Choline O-Acetyltransferase (CHAT) interaction partners

  1. cholinergic transmission in the knock-out dorsal motor nucleus of vagus was overactivated because knock-out mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase)

  2. Study describes in detail a population of choline acetyltransferase immunoreactive /glutamate decarboxylase 67 (show GAD1 Proteins) neurons predominantly ventral to the central canal of the cervical, thoracic and lumbar spinal cord of adult and juvenile mice. These cells potentially correspond to a sub-population of the cholinergic central canal cluster cells which may play a unique role in controlling spinal cord circuitry.

  3. The isolation and characterization of CD4 (show CD4 Proteins) TChAT cells will enable analysis of the role of these cells in hypotension and hypertension, and may suggest novel therapeutic strategies by targeting cell-mediated vasorelaxation.

  4. Microgravity causes substantial down-regulation of nerve tissue proteins, choline acetyltransferase, NF200 (show NEFH Proteins), and calbindin (show CALB1 Proteins) in mouse motor neurons.

  5. These studies indicate a novel relationship between cholinergic neurons and APP (show APP Proteins) processing, with 82-kDa ChAT acting as a negative regulator of Abeta (show APP Proteins) production

  6. increased REST/NRSF expression and its effect on the regulatory region for choline acetyltransferase (ChAT) transcription could explain the decreased expression of ChAT in the Alzheimer's disease transgenic mouse

  7. chronic social defeat stress in mice produces stress-related behaviors; a decrease in the Chat level at days 12 and 27 was noted in the prefrontal cortex (PFC (show CFP Proteins)), amygdala (Amyg), and dorsal hippocampus (HIP) in defeated mice

  8. In choline acetyltransferase transgenic mice the activated cardiac ACh (show FGFR3 Proteins)-HIF-1alpha (show HIF1A Proteins) cascade improves survival after myocardial infarction.

  9. After bilateral common carotid artery occlusion, peripherin (show PRPH Proteins) overexpression was significantly correlated with reduction in ChAT activity

  10. Histone deacetylase 9 (HDAC9 (show HDAC9 Proteins)) represses ChAT gene expression in NG108-15 neuronal cells and thus plays an important role in cholinergic differentiation.

Zebrafish Choline O-Acetyltransferase (CHAT) interaction partners

  1. We have identified a zebrafish mutant line, bajan, in which compromised motility and fatigue result from a point mutation in the gene coding choline acetyltransferase

Human Choline O-Acetyltransferase (CHAT) interaction partners

  1. Compared with the control group, the densitometric quantification and mean density of GPR43 (show FFAR2 Proteins) and ChAT proteins, and expression of GPR43 (show FFAR2 Proteins) and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

  2. Results suggest that SATB1 (show SATB1 Proteins) is activated to bind to chromatin at S/MARs after exposure to Abeta (show APP Proteins) 1-42, resulting in alternative utilization and movement of 82-kDa ChAT to these regions demonstrating that both proteins play critical roles in the response of neural cells to acute Abeta (show APP Proteins)-exposure.

  3. We conducted a meta-analysis of studies involving CHAT, TFAM (show TFAM Proteins), and VR22 (show CTNNA3 Proteins) polymorphisms and Alzheimer disease susceptibility.For CHAT, rs2177369 (G>A) in whites and rs3810950 (G>A) in Asians were found to be associated with AD susceptibility. No association was detected between rs1880676 and rs868750 and AD risk.

  4. There is a striking variability in the severity of phenotypes resulting from mutations in CHAT, which is the only gene so far known to be linked with congenital deficiency of ACh (show FGFR3 Proteins) synthesis.

  5. Data show thata the expression of choline acetyltransferase (ChAT) is reduced in the postmortem alcoholic basal forebrain in comparison to moderate drinking controls.

  6. These studies indicate a novel relationship between cholinergic neurons and APP (show APP Proteins) processing, with 82-kDa ChAT acting as a negative regulator of Abeta (show APP Proteins) production

  7. There was a loss of choline O-acetyltransferase in the visual cortex of dementia with Lewy bodies patients.

  8. the functional consequences of 12 missense and one nonsense mutations of CHAT in 11 patients. ( choline acetyltransferase)

Pig (Porcine) Choline O-Acetyltransferase (CHAT) interaction partners

  1. The results revealed broad coexistence of ChAT and CGRP (show CALCA Proteins) in the spinal cord neurons which implies that the neurons synthesize and store ChAT and CGRP (show CALCA Proteins) in their cell bodies.

CHAT Protein Profile

Protein Summary

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.

Alternative names and synonyms associated with CHAT

  • choline acetyltransferase (PGTG_00551)
  • choline acetyltransferase (LOC100533322)
  • choline acetyltransferase (Chat)
  • choline acetyltransferase (chat)
  • choline O-acetyltransferase (CHAT)
  • choline O-acetyltransferase (Chat)
  • B230380D24Rik protein
  • ChoAcTase protein
  • CMS1A protein
  • CMS1A2 protein

Protein level used designations for CHAT

choline acetyltransferase , CHOACTase , choline O-acetyltransferase , choline acetylase , baj , acetyl CoA:choline O-acetyltransferase

10528159 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100533322 Aplysia californica
12647 Mus musculus
100170938 Danio rerio
1103 Homo sapiens
290567 Rattus norvegicus
751512 Felis catus
100718930 Cavia porcellus
395314 Gallus gallus
450451 Pan troglodytes
486775 Canis lupus familiaris
396896 Sus scrofa
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