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Browse our anti-Mitofusin 2 (MFN2) Antibodies

Full name:
anti-Mitofusin 2 Antibodies (MFN2)
On www.antibodies-online.com are 171 Mitofusin 2 (MFN2) Antibodies from 25 different suppliers available. Additionally we are shipping Mitofusin 2 Proteins (10) and Mitofusin 2 Kits (7) and many more products for this protein. A total of 198 Mitofusin 2 products are currently listed.
Synonyms:
anon-WO0125274.3, CG3869, CMT2A, CMT2A2, CPRP1, D630023P19Rik, Dmel\\CG3869, dmfn, Fzo, HSG, marf, Marf-1, mfn, MFN2, mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11
list all antibodies Gene Name GeneID UniProt
MFN2 9927 O95140
MFN2 170731 Q80U63
MFN2 64476  

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Top referenced anti-Mitofusin 2 Antibodies

  1. Human Monoclonal MFN2 Primary Antibody for IHC (p), ELISA - ABIN523306 : Stacchiotti, Favero, Giugno, Lavazza, Reiter, Rodella, Rezzani: Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. in PLoS ONE 2014 (PubMed)

  2. Human Polyclonal MFN2 Primary Antibody for IHC, IHC (p) - ABIN4334778 : Yang, Yang: Bit-by-bit autophagic removal of parkin-labelled mitochondria. in Nature communications 2013 (PubMed)

  3. Cow (Bovine) Polyclonal MFN2 Primary Antibody for IHC, WB - ABIN2775408 : Chung, Cho, Hwang, Kim, Yoo, Kwon, Kim, Sunwoo, Züchner, Choi: Early-onset stroke associated with a mutation in mitofusin 2. in Neurology 2008 (PubMed)

  4. Human Polyclonal MFN2 Primary Antibody for IHC (p), WB - ABIN568087 : Santel, Fuller: Control of mitochondrial morphology by a human mitofusin. in Journal of cell science 2001 (PubMed)

  5. Human Polyclonal MFN2 Primary Antibody for IF (p), IHC (p) - ABIN682528 : Ku, Ji, Zhang, Li, Sang: PM2.5, SO2 and NO2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain. in Chemosphere 2016 (PubMed)

More Antibodies against Mitofusin 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) interaction partners

  1. lack of ChChd3 (show CHCHD3 Antibodies) leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki (show YAP1 Antibodies)). Furthermore, loss of ChChd3 (show CHCHD3 Antibodies) induces oxidative stress and activates the JNK (show MAPK8 Antibodies) pathway. In addition, depletion of other mitochondrial fusion components, Opa1 (show OPA1 Antibodies) or Marf, inactivates the Hippo pathway as well.

  2. Marf is required for mitochondrial fusion and transport in long axons.

  3. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  4. Parkin (show PARK2 Antibodies) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  5. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  6. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  7. MARF and Opa1 (show OPA1 Antibodies) control mitochondrial and cardiac function in Drosophila.

  8. The PINK1 (show PINK1 Antibodies)/Parkin (show PARK2 Antibodies) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

  9. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut (show GUSB Antibodies) development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line.

Human Mitofusin 2 (MFN2) interaction partners

  1. Taken together, these data suggest that the striking reduction in mitochondria in MNs (show FLNA Antibodies) expressing mutant MFN2 is not the result of impaired biogenesis, but more likely the consequence of enhanced mitophagy.

  2. our findings indicate miR (show MLXIP Antibodies)-106a as an important factor to promote hypertrophic progress and suggest miR (show MLXIP Antibodies)-106a as a new molecular target for the treatment of pathological hypertrophy. The present study also uncovered a novel relationship between miR (show MLXIP Antibodies)-106a and Mfn2, with Mfn2 as a downstream signaling mediator of miR (show MLXIP Antibodies)-106a.

  3. The results of the present study demonstrated that Resveratrol may protect bronchial epithelial cells from cigarette smoke -induced apoptosis in vitro by preventing mitochondrial dysfunction, and MFN2 may be associated with the anti-apoptotic functions of RSV in HBE (show HBe1 Antibodies) cells.

  4. Low MFN2 expression in hepatocellular carcinoma indicated a worse overall survival.

  5. Low expression of MFN2 is associated with lung adenocarcinoma.

  6. Between 1999 and 2012, the genetic diagnosis of MFN2 mutation was made in 11 children who were treated in our department for different neurological symptoms. We found 5 different mutations in the MFN2 gene in 6 unrelated families

  7. We report four novel mutations and four rare missense variants of MFN2 in Charcot-Marie-Tooth disease 2A families in mainland China

  8. The results of this study suggested that the MFN2 gene should be considered in Polish hereditary motor-sensory neuropathiey II patients.

  9. These results suggest that defects in Mfn2 could cause mitochondrial dysfunction and decrease trophoblastic cells' viability

  10. This study demonstrated that Mfn2 gene polymorphisms were associated with essential hypertension in northern Han Chinese population, especially in male subjects

Mouse (Murine) Mitofusin 2 (MFN2) interaction partners

  1. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  2. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (show CRMP1 Antibodies) during chondrogenesis resulted in a loss of differentiation ability

  3. SIRT1 (show SIRT1 Antibodies) overexpression substantially increased autophagy in wild-type cells, but not in MFN2-deficient cells.

  4. mitofusin 2 overexpression may attenuate hypoxia-induced apoptosis.

  5. Mitofusin 2, in addition to its role in mitochondrial fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway.

  6. suggest a balance between negative metabolic consequences of mitofusin 2 deficiency and adaptive processes exemplified by increased level of PGC-1alpha (show PPARGC1A Antibodies) and TFAM (show TFAM Antibodies) transcription factor which prevent an depletion of mtDNA and severe impairment of cell metabolism

  7. Our results indicate that HDAC6 (show HDAC6 Antibodies) is a critical regulator of MFN2 degradation by MARCH5 (show MARCH5 Antibodies), thus protecting mitochondrial connectivity from hypoxic stress.

  8. Mfn2 attenuates the blastocyst formation rate and cleavage speed in mouse zygotes and causes mitochondrial dysfunction, as confirmed by the ATP and mtDNA levels and mitochondrial membrane potential.

  9. Mfn2 is specifically required for the maintenance of hematopoietic stem cells (HSCs) with extensive lymphoid potential, but not, or less so, for the maintenance of myeloid-dominant HSCs

  10. confirm the hypothesis that the cellular consequences of mutations in the mitofusin 2 gene can mostly be manifested in the peripheral nervous system

Zebrafish Mitofusin 2 (MFN2) interaction partners

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) interaction partners

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (show MFN1 Antibodies).

Mitofusin 2 (MFN2) Antigen Profile

Antigen Summary

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Mitofusin 2 (MFN2)

  • mitofusin 2 (MFN2) antibody
  • Mitochondrial assembly regulatory factor (Marf) antibody
  • mitofusin 2 (mfn2) antibody
  • mitofusin 2 (Mfn2) antibody
  • mitofusin 2 (LOC100350119) antibody
  • anon-WO0125274.3 antibody
  • CG3869 antibody
  • CMT2A antibody
  • CMT2A2 antibody
  • CPRP1 antibody
  • D630023P19Rik antibody
  • Dmel\\CG3869 antibody
  • dmfn antibody
  • Fzo antibody
  • HSG antibody
  • marf antibody
  • Marf-1 antibody
  • mfn antibody
  • MFN2 antibody
  • mg:cb01g09 antibody
  • si:dkeyp-104h9.2 antibody
  • wu:fb79a11 antibody

Protein level used designations for anti-Mitofusin 2 (MFN2) Antibodies

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

GENE ID SPECIES
100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
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