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Browse our Mitofusin 2 Proteins (MFN2)

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Mitofusin 2 Proteins (MFN2)
On are 10 Mitofusin 2 (MFN2) Proteins from 4 different suppliers available. Additionally we are shipping Mitofusin 2 Antibodies (174) and Mitofusin 2 Kits (6) and many more products for this protein. A total of 200 Mitofusin 2 products are currently listed.
anon-WO0125274.3, CG3869, CMT2A, CMT2A2, CPRP1, D630023P19Rik, Dmel\\CG3869, dmfn, Fzo, HSG, marf, Marf-1, mfn, MFN2, mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11
list all proteins Gene Name GeneID UniProt
MFN2 9927 O95140
MFN2 170731 Q80U63
MFN2 64476  

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Mitofusin 2 Proteins (MFN2) by Origin

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Top referenced Mitofusin 2 Proteins

  1. Human MFN2 Protein expressed in Human - ABIN2726078 : Wang, Zhang, Li, Tang, Siedlak, Fujioka, Liu, Su, Pi, Wang: MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for Mitofusin 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) interaction partners

  1. Marf is required for mitochondrial fusion and transport in long axons.

  2. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  3. Parkin (show PARK2 Proteins) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  4. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  5. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  6. MARF and Opa1 (show OPA1 Proteins) control mitochondrial and cardiac function in Drosophila.

  7. The PINK1 (show PINK1 Proteins)/Parkin (show PARK2 Proteins) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

  8. Dmfn-mRNA was widely expressed during embryogenesis accumulating in the mesoderm and endoderm during gut (show GUSB Proteins) development, during oogenesis with transcripts maternally deposited into the early embryo and in the male germ line.

Human Mitofusin 2 (MFN2) interaction partners

  1. The results of the present study demonstrated that Resveratrol may protect bronchial epithelial cells from cigarette smoke -induced apoptosis in vitro by preventing mitochondrial dysfunction, and MFN2 may be associated with the anti-apoptotic functions of RSV in HBE (show HBe1 Proteins) cells.

  2. Low MFN2 expression in hepatocellular carcinoma indicated a worse overall survival.

  3. Low expression of MFN2 is associated with lung adenocarcinoma.

  4. Between 1999 and 2012, the genetic diagnosis of MFN2 mutation was made in 11 children who were treated in our department for different neurological symptoms. We found 5 different mutations in the MFN2 gene in 6 unrelated families

  5. We report four novel mutations and four rare missense variants of MFN2 in Charcot-Marie-Tooth disease 2A families in mainland China

  6. The results of this study suggested that the MFN2 gene should be considered in Polish hereditary motor-sensory neuropathiey II patients.

  7. These results suggest that defects in Mfn2 could cause mitochondrial dysfunction and decrease trophoblastic cells' viability

  8. This study demonstrated that Mfn2 gene polymorphisms were associated with essential hypertension in northern Han Chinese population, especially in male subjects

  9. Report exposes a novel role for Shh (show SHH Proteins) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 (show MFN1 Proteins) and 2.

  10. family study of early onset severe axonal Charcot-Marie-Tooth disease with dominant inheritance - SNP mutation in MFN2

Mouse (Murine) Mitofusin 2 (MFN2) interaction partners

  1. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 during chondrogenesis resulted in a loss of differentiation ability

  2. SIRT1 (show SIRT1 Proteins) overexpression substantially increased autophagy in wild-type cells, but not in MFN2-deficient cells.

  3. mitofusin 2 overexpression may attenuate hypoxia-induced apoptosis.

  4. Mitofusin 2, in addition to its role in mitochondrial fusion, is important for maintaining coenzyme Q levels and may be an integral player in the mevalonate synthesis pathway.

  5. suggest a balance between negative metabolic consequences of mitofusin 2 deficiency and adaptive processes exemplified by increased level of PGC-1alpha and TFAM (show TFAM Proteins) transcription factor which prevent an depletion of mtDNA and severe impairment of cell metabolism

  6. Our results indicate that HDAC6 (show HDAC6 Proteins) is a critical regulator of MFN2 degradation by MARCH5 (show MARCH5 Proteins), thus protecting mitochondrial connectivity from hypoxic stress.

  7. Mfn2 attenuates the blastocyst formation rate and cleavage speed in mouse zygotes and causes mitochondrial dysfunction, as confirmed by the ATP and mtDNA levels and mitochondrial membrane potential.

  8. Mfn2 is specifically required for the maintenance of hematopoietic stem cells (HSCs) with extensive lymphoid potential, but not, or less so, for the maintenance of myeloid-dominant HSCs

  9. confirm the hypothesis that the cellular consequences of mutations in the mitofusin 2 gene can mostly be manifested in the peripheral nervous system

  10. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1 (show MFN1 Proteins), Mfn2, OPA1 (optic atrophy 1 (show OPA1 Proteins) protein), and Drp1 (dynamin 1-like protein (show DNM1L Proteins)). [REVIEW]

Zebrafish Mitofusin 2 (MFN2) interaction partners

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) interaction partners

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (show MFN1 Proteins).

Mitofusin 2 (MFN2) Protein Profile

Protein Summary

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Mitofusin 2 (MFN2)

  • mitofusin 2 (MFN2)
  • Mitochondrial assembly regulatory factor (Marf)
  • mitofusin 2 (mfn2)
  • mitofusin 2 (Mfn2)
  • mitofusin 2 (LOC100350119)
  • anon-WO0125274.3 protein
  • CG3869 protein
  • CMT2A protein
  • CMT2A2 protein
  • CPRP1 protein
  • D630023P19Rik protein
  • Dmel\\CG3869 protein
  • dmfn protein
  • Fzo protein
  • HSG protein
  • marf protein
  • Marf-1 protein
  • mfn protein
  • MFN2 protein
  • mg:cb01g09 protein
  • si:dkeyp-104h9.2 protein
  • wu:fb79a11 protein

Protein level used designations for Mitofusin 2 Proteins (MFN2)

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
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