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Syntaxin 18 (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor (show VTI1B Proteins)) is required for expansion of postsynaptic membranes during new synapse formation.
The SNP rs12644497 in the STX18 gene was associated with congenital heart diseases Chinese Han populations.
RINT-1 (show RINT1 Proteins) coordinates the localization and function of ZW10 (show ZW10 Proteins) by serving as a link between ZW10 (show ZW10 Proteins) and the SNARE (show NAPA Proteins) complex comprising syntaxin 18.
Stx18 in involved in growth of human breast cancer cells and may possibly be used as a prognostic marker and a molecular target in the treatment of breast cancer.
Suggest that syntaxin 18 has an important role in ER subdomain organization by mediating the fusion of retrograde membrane carriers with the ER membrane.
Domain analyses of Sec22b revealed that the R-SNARE motif, a selective domain for forming a SNARE complex with syntaxin18 and/or D12, was responsible for the inhibition of phagocytosis.
Syntaxin 18 is involved in endoplasmic reticulum (ER)-mediated phagocytosis, presumably by regulating the specific and direct fusion of the ER and plasma or phagosomal membranes.
Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity).
, syntaxin 18
, cell growth-inhibiting gene 9 protein