Browse our ASCL2 Proteins (ASCL2)

Full name:
Achaete-Scute Complex Homolog 2 (Drosophila) Proteins (ASCL2)
On are 6 Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) Proteins from 4 different suppliers available. Additionally we are shipping ASCL2 Antibodies (63) and ASCL2 Kits (12) and many more products for this protein. A total of 86 ASCL2 products are currently listed.
2410083I15Rik, ASCL2, ASH2, ASH2L1, ASH2L2, bHLHa45, Bre2, HASH2, Mash2
list all proteins Gene Name GeneID UniProt
ASCL2 17173 O35885
ASCL2 24209 P19360
ASCL2 430 Q99929

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ASCL2 Proteins (ASCL2) by Origin

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More Proteins for ASCL2 Interaction Partners

Cow (Bovine) Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) interaction partners

  1. More DNMT1 (show DNMT1 Proteins) mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos.

  2. Mash2 is highly conserved across species and is specifically expressed in the bovine placenta. Bovine Mash2 appears to be maternally expressed after implantation, but the paternal genome plays a role in regulating expression.

Pig (Porcine) Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) interaction partners

  1. The lack of differential expression by microarray profiling of fetal tissues from swine parthenotes and control bi-parental fetuses supports lack of imprinting at ASCL2 in pigs.

Mouse (Murine) Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) interaction partners

  1. overexpression of the imprinted Ascl2 gene has considerable consequences for placental development, specifically for the parietal trophoblast giant cell and spongiotrophoblast lineages both of which express pregnancy-related hormones.

  2. The ascl2 forms a transcriptional switch that is both Wnt (show WNT2 Proteins) responsive and Wnt (show WNT2 Proteins) dependent to define stem cell identity.

  3. Ascl2 directly initiates follicular T-helper cell development

  4. TSSC3 (show PHLDA2 Proteins) plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3 (show PHLDA2 Proteins)/PI3K/AKT (show AKT1 Proteins)/MASH2 signaling pathway.

  5. Elevated expression of Ascl2 in a Wnt (show WNT2 Proteins) signalling dependent manner specifically in the stem cell compartment of the intestine neither increases tumour formation nor diminishes survival in a well established intestinal tumour model, the Apc (show APC Proteins)(min) mouse.

  6. Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells

  7. Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.

  8. Mash2 gene is preferentially expressed from the paternal allele.

  9. The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the mouse model of Beckwith-Wiedemann Syndrome.

  10. Mash2 is a regulator of Krox24, Mob-1, and CXCR4 expression in cultured Schwann cells and negatively regulates their proliferation; a candidate for missing class B bHLH proteins in peripheral nerves

Human Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) interaction partners

  1. Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (show TNF Proteins)) induced proinflammatory transcription in macrophages.

  2. Ascl2 over-expression is associated with colorectal neoplasms.

  3. expression of ASCL2 may identify an aggressive subgroup in lung squamous cell carcinoma

  4. the histone methyltransferase core enzyme ASH2L (show ASH2L Proteins) was bound at EGFR (show EGFR Proteins) in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 (show EP300 Proteins) was bound in samples with H3K27ac enrichment

  5. SEMA3F (show SEMA3F Proteins) functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 (show CXCR4 Proteins) signaling axis.

  6. SNAIL1 (show SNAI1 Proteins) combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 (show EPHB3 Proteins) tumor suppressor in colorectal cancer.

  7. Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.

  8. ASCL2 gene expression is regulated by miR (show MLXIP Proteins)-200a/b/c, miR (show MLXIP Proteins)-141 and miR429 levels in colon cancer.

  9. ASH2L (show ASH2L Proteins) enhances ERalpha (show ESR1 Proteins) expression as a coactivator of GATA3 (show GATA3 Proteins) in breast cancers

  10. Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5 (show RBBP5 Proteins)/Ash2L (show ASH2L Proteins) heterodimer.

ASCL2 Protein Profile

Protein Summary

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Alternative names and synonyms associated with ASCL2

  • achaete-scute complex-like protein 2 (mash2)
  • achaete-scute complex homolog 2 (Drosophila) (ASCL2)
  • achaete-scute complex homolog 2 (Drosophila) (Ascl2)
  • ash2 (absent, small, or homeotic)-like (Drosophila) (ASH2L)
  • 2410083I15Rik protein
  • ASCL2 protein
  • ASH2 protein
  • ASH2L1 protein
  • ASH2L2 protein
  • bHLHa45 protein
  • Bre2 protein
  • HASH2 protein
  • Mash2 protein

Protein level used designations for ASCL2

achaete-scute complex-like protein 2 , achaete-scute complex homolog 2 (Drosophila) , achaete-scute complex homolog-like 2 , achaete-scute homolog 2 , achaete scute-like protein 2 , ASH-2 , long transient receptor potential-related channel 5 , mASH-2 , mammalian achaete scute homolog 2 , mash2 , transcription factor cash4 , achaete-scute complex-like 2 , class A basic helix-loop-helix protein 45 , mammalian achaete/scute homologue 2 , ASH2-like protein , set1/Ash2 histone methyltransferase complex subunit ASH2

414840 Bos taurus
466319 Pan troglodytes
100144467 Sus scrofa
664650 Bos taurus
17173 Mus musculus
24209 Rattus norvegicus
395791 Gallus gallus
430 Homo sapiens
483666 Canis lupus familiaris
9070 Homo sapiens
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