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Functional studies revealed that knockdown of Nanog eliminated the mESC self-renewal-promoting ability of Sp5. Finally, we demonstrated that the self-renewal-promoting function of Sp5 was largely dependent on its zinc finger domains
Otx2 (show OTX2 Proteins)-mediated Nanog (show NANOG Proteins) regulation contributes to the integrity of the embryonic stem cell state and cell lineage specification in preimplantation development (show MTA2 Proteins).
Maintenance of pluripotency is regulated by a network of transcription factors coordinated by Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins), and Nanog (show NANOG Proteins); Trim24 (show TRIM24 Proteins) significantly improved efficiency of cellular reprogramming, demonstrating its direct functionality in establishing pluripotency.
studies highlight a new hypoxia-induced pathway in which NANOG (show NANOG Proteins) activates BNIP3L (show BNIP3L Proteins) expression, contributing to autophagy induction in hypoxic tumor cells and their resistance to killing by CTL
Genetic reporters can compromise the behavior of important pluripotency-sustaining positive feedback loops, and induce a bifurcation in the underlying dynamics that gives rise to heterogeneous Nanog expression patterns in reporter cell lines that are not representative of the wild-type; findings help explain the range of published observations of Nanog variability and highlight the problem of measurement in live cells.
Here the authors couple mutagenesis with functional and dimerization assays to show that the number of tryptophans within the tryptophan repeat is linked to the strength of homodimerization, Sox2 (show SOX2 Proteins) heterodimerization and self-renewal activity.
In mouse model of acute uterine injury, Nanog (show NANOG Proteins) homebox (NANOG (show NANOG Proteins)) expression reached a peak at 6 h, while sex-determining region Y (show SRY Proteins)-box2 (SOX2 (show SOX2 Proteins)) and octamer-binding protein 4 (OCT4 (show POU5F1 Proteins)) peaked later at 12 h after lipopolysaccharide (LPS (show TLR4 Proteins)) treatment.
NANOG as a key regulator connecting the pluripotency network with constitutive heterochromatin organization in mouse embryonic stem cells.
Data indicate that Nanog homeobox (show NANOG Proteins) protein (show HOXA1 Proteins) is important for the effects of reprogramming media.
Nanog (show NANOG Proteins) enhances proliferation of fibroblasts through transcriptional regulation of cell cycle inhibitor p27 (show CDKN1B Proteins) gene.
The expression of the genes coding for proopiomelanocortin (POMC (show POMC Proteins)), proenkephalin (PENK) and prodynorphin (PDYN (show PDYN Proteins)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
Nav1.7 (show SCN9A Proteins) deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk mRNA and met-enkephalin protein in sensory neurons.
The PENK polymorphism-and potentially opioid neurotransmission more generally-modulates functioning and structural integrity of brain regions.
Serum PENK-A levels were not associated with all-cause mortality in patients with type 2 diabetes mellitus, and its association with cardiovascular mortality was strongly attenuated after accounting for all traditional risk factors.
BSP (show KLK6 Proteins) demonstrated that emodin, to a certain degree, affected the demethylation of tumor-suppressor genes P16, RASSF1A (show RASSF1 Proteins), and ppENK in the pancreatic cancer cell line PANC-1.
increased plasma PENK-A levels are associated with disease severity and in-hospital mortality after acute intracerebral hemorrhage.
enhanced plasma proenkephalin A could be a useful, complementary tool to predict short- or long-term clinical outcome after severe traumatic brain injury.
EPS led to the discovery of two novel immunomodulatory proteins, MFAP5 (show MFAP5 Proteins) and PENK that when administered to mice subjected to endotoxemic shock, reversed the cytokine storm and provided a significant survival benefit
Data from women undergoing hysterectomy for uterine fibroids suggest that uterine isthmian-cervical region exhibits nerve fibers expressing enkephalin (ENK); uterine fundus/corpus myoma pseudocapsules do not exhibit nerve fibers expressing ENK.
Promoter methylation of WIF1 (show WIF1 Proteins), PENK and NPY (show NPY Proteins) is associated with colorectal adenocarcinoma (CRC (show CALR Proteins)) diagnosis and can be used to CRC (show CALR Proteins) from other cancers.
Expression of preproenkephalin is significantly decreased in brain from HIV-1 infected patients compared to HIV-1 negative subjects.
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT-3'. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
, Proenkephalin A
, enkephalin a
, ES cell-associated protein 4
, early embryo specific expression NK family
, early embryo specific expression NK-type homeobox protein
, homeobox protein NANOG
, homeobox transcription factor Nanog
, preproenkephalin 1
, spermatogenic-specific proenkephalin
, preproenkephalin 2
, proenkephalin 1
, proenkephalin 2
, proenkephalin related sequence
, enkephalin A