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anti-Human KLF10 Antibodies:
anti-Mouse (Murine) KLF10 Antibodies:
anti-Rat (Rattus) KLF10 Antibodies:
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In clinical specimens of lung adenocarcinoma, low KLF10 expression associated with decreased patient survival, consistent with a pivotal role for KLF10 in distinguishing the antiproliferative versus prometastatic functions of TGFbeta (show TGFB1 Antibodies). Our results establish that KLF10 functions to suppress TGFb (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies), establishing a molecular basis for the dichotomy of TGFb (show TGFB1 Antibodies) function during tumor progression.
the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 (show SMAD7 Antibodies) promoter-mediated activation of TGF-beta (show TGFB1 Antibodies)/Smad2 (show SMAD2 Antibodies) signaling
TIEG-1 overexpression in normal human skin fibroblasts results in improved resistance to oxidative stress
CDK2 (show CDK2 Antibodies) up-regulates the protein level of KLF10 through reducing its association with SIAH1 (show SIAH1 Antibodies), a KLF10 E3-ubiqutin ligase involved in proteasomal degradation.
KLF10 directly binds to TGF-BRII promoter in T cells, leading to enhanced gene expression.
The tumor suppressor function of LSAMP (show LSAMP Antibodies) is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 (show CTAG2 Antibodies) or KLF10.
KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 (show FOXP3 Antibodies) via Sin3-HDAC (show HDAC3 Antibodies)/PCAF (show KAT2B Antibodies) pathway and, thus, immune activation.
RAF-1 (show RAF1 Antibodies) phosphorylation and PIN1 (show PIN1 Antibodies) isomerization together regulate KLF10 stability and further affect the role of KLF10 in tumor progression.
KLF10 is an effective repressor of myoblast proliferation and represses FGFR1 (show FGFR1 Antibodies) promoter activity in these cells via an Sp1 (show PSG1 Antibodies) binding site.
KLF10 may constitute a pharmacogenomic marker to discriminate between response and nonresponse to hydroxyurea treatment in beta-hemoglobinopathy patients.
Authors demonstrate that targeting the SDF-1 (show CXCL12 Antibodies)/CXCR4 (show CXCR4 Antibodies) pathway in the context of KLF10 deletion substantially suppresses PDAC progression.
In an animal endometriosis model, unlike wild-type controls, Klf10(-/-) animals developed cystic lesions with massive immune infiltrate and minimal peri (show POSTN Antibodies)-lesional fibrosis. The Klf10(-/-) disease progression phenotype also contrasted with prolific fibrosis and minimal immune cell infiltration seen in Klf11 (show KLF11 Antibodies)(-/-) animals.
TIEG1 is involved in regulating the canonical Wnt (show WNT2 Antibodies) signaling pathway in bone through multiple mechanisms of action.
This study further implicates important roles for TIEG1 in the development of skeletal muscle and suggests that defects in TIEG1 expression and/or function may be associated with muscle disease.
Study has provided new insights into the role of TIEG1 in the functional and morphological properties of fast and slow twitch skeletal muscles.
our findings indicate that the absence of TIEG1 plays a cardioprotective role in ischaemic heart disease by promoting changes in Pten (show PTEN Antibodies)/Akt (show AKT1 Antibodies) signalling.
Klf10 is involved in tooth development and promotes odontoblastic differentiation via the up-regulation of Dmp1 (show DMP1 Antibodies) and Dspp (show DSPP Antibodies) transcription.
Decreased expression of Osterix (show SP7 Antibodies), as well as impaired TGFbeta (show TGFB1 Antibodies) and BMP2 (show BMP2 Antibodies) signaling, contribute to the observed osteopenic bone phenotype of TIEG1 KO mice.
KLF10 deficiency predisposes to colitis through epigenetic regulation of TGFBRII expression and colonic macrophage dysregulation.
Kruppel-like zinc finger transcription factor; involved in TGFbeta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth
Kruppel-like factor 10
, Krueppel-like factor 10
, TGFB-inducible early growth response protein 1
, early growth response-alpha
, transforming growth factor-beta-inducible early growth response protein 1
, zinc finger transcription factor TIEG
, TGF-beta inducible early growth response protein 1
, GDNF-inducible factor
, TGFB inducible early growth response 1
, transcription factor GIF
, TGFB inducible early growth response
, zinc finger transcription factor homolog CPG20