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Microcephalin 1 ELISA Kits (MCPH1)
On are 2 Microcephalin 1 (MCPH1) ELISA Kits from 1 different suppliers available. Additionally we are shipping MCPH1 Antibodies (85) and MCPH1 Proteins (4) and many more products for this protein. A total of 97 MCPH1 products are currently listed.
5430437K10Rik, BRIT1, D030046N04Rik, MCPH1, MCT, MGC83773, MGC148665, RGD1560642
list all ELISA KIts Gene Name GeneID UniProt
Rat MCPH1 MCPH1 306594  
MCPH1 79648 Q8NEM0
MCPH1 244329 Q7TT79

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Human Microcephalin 1 (MCPH1) interaction partners

  1. Candidate tumor suppressor gene MCPH1 is mutated in colorectal and gastric cancers.

  2. Characterization of the effects of MCPH1 loss-of-function on chromosome morphology.

  3. Results show that in addition to the scaffolding function in complex formation, BRUCE (show BIRC6 ELISA Kits) has an E3 ligase function to promote BRIT1 deubiquitination by USP8 (show USP8 ELISA Kits) leading to accumulation of BRIT1 at DNA double-strand break.

  4. Data indicate splice-acceptor site homozygous mutation in intron 4 of microcephalin (MCPH1) gene in 2 children.

  5. in addition to its role in brain development, MCPH1 also functions as a tumor suppressor gene and is directly regulated by miR (show MLXIP ELISA Kits)-27a.

  6. BRUCE (show BIRC6 ELISA Kits) acts as a scaffold, bridging the ubiquitin-specific peptidase 8 (USP8 (show USP8 ELISA Kits)) and BRIT1 in a complex to coordinate USP8 (show USP8 ELISA Kits)-catalyzed deubiquitination of BRIT1.

  7. SNTB1 (show SNTB1 ELISA Kits) and MCPH1 are located on chromosome 8, which may be involved in neuroticism, avoidant personality and depression.

  8. Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage.

  9. MCPH1 has an important role in regulating cell growth through regulating the cell cycle and apoptosis

  10. This study identified MCPH1 significantly associated loci with a biologically plausible role in schizophrenia.

Chimpanzee Microcephalin 1 (MCPH1) interaction partners

  1. sequence comparison of vertebrate species suggested that the identified E2F1 (show E2F1 ELISA Kits) binding motif is primate specific, consistent with the previous observation of rapid evolution of MCPH1 protein sequence in primates

Mouse (Murine) Microcephalin 1 (MCPH1) interaction partners

  1. MCPH1 is a bona fide tumor suppressor gene.

  2. Mcph1-deficient mice reveal a role for MCPH1 in otitis media. Expression of Mcph1 in the epithelial cells of middle ear cavities supported its involvement in the development of otitis media.

  3. MCPH1, through its function in the Chk1 (show CHEK1 ELISA Kits)-Cdc25 (show CDC25C ELISA Kits)-Cdk1 (show CDK1 ELISA Kits) pathway to couple the centrosome cycle with mitosis, is required for precise mitotic spindle orientation and thereby regulates the progenitor division mode to maintain brain size.

  4. VIP (show Vip ELISA Kits) blockade induces microcephaly through Mcph1 signaling; VIP (show Vip ELISA Kits)/Mcph1/Chk1 (show CHEK1 ELISA Kits) signaling is key for normal cortical development

  5. SET is an important regulator of chromosome condensation/decondensation and disruption of the MCPH1-SET interaction might be important for the pathogenesis of primary microcephaly

  6. Data did not show clear signs of premature malignant disease development due to the perturbed Mcph1 function.

  7. Craniosynostosis-microcephaly with chromosomal breakage and other abnormalities is caused by a truncating MCPH1 mutation

  8. MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability.

MCPH1 Antigen Profile

Antigen Summary

This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with MCPH1

  • microcephalin 1 (Mcph1) Elisa Kit
  • microcephalin 1 (mcph1) Elisa Kit
  • microcephalin 1 (MCPH1) Elisa Kit
  • microcephaly, primary autosomal recessive 1 (MCPH1) Elisa Kit
  • microcephaly, primary autosomal recessive 1 (Mcph1) Elisa Kit
  • 5430437K10Rik Elisa Kit
  • BRIT1 Elisa Kit
  • D030046N04Rik Elisa Kit
  • MCPH1 Elisa Kit
  • MCT Elisa Kit
  • MGC83773 Elisa Kit
  • MGC148665 Elisa Kit
  • RGD1560642 Elisa Kit

Protein level used designations for Microcephalin 1 (MCPH1) ELISA Kits

microcephaly, primary autosomal recessive 1 , microcephalin 1 , microcephalin , BRCT-repeat inhibitor of TERT expression 1

306594 Rattus norvegicus
431960 Xenopus laevis
442960 Canis lupus familiaris
493941 Felis catus
100038095 Xenopus (Silurana) tropicalis
100125236 Bos taurus
100125976 Gallus gallus
100505404 Ovis aries
79648 Homo sapiens
449589 Pan troglodytes
244329 Mus musculus
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