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results indicate that decreased Cav-1 (show CAV1 ELISA Kits) in Emu-TCL1 mice significantly delays the onset of CLL and decreases leukemic progression by inhibiting MAPK-Erk (show MAPK1 ELISA Kits) signaling, suggesting a role for Cav-1 (show CAV1 ELISA Kits) in the proliferation and progression of CLL
This review discusses the main features of the original TCL1 models and the different lines of research successively developed with particular attention to genetically compound mice and the therapeutic applications in drug development.
Tcl1 expression downregulated a distinct group of genes, including Ndp52 (show CALCOCO2 ELISA Kits), whose expression is very high in blastocysts but reduced in the primitive ectoderm.
Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI (show TNFRSF13B ELISA Kits) activation.
These findings demonstrate cooperation of Tcl1 and the NF-kB pathway in the pathogenesis of aggressive chronic lymphocytic leukemia.
An important role of TCL1 in activating the ER stress response in support for malignant progression of chronic lymphocytic leukemia.
TCL1 and/or other genes in the TCL1 pathway are responsible for the initiation of human chronic lymphocytic leukemia.
Akt (show AKT1 ELISA Kits) kinase activity can be inhibited by a peptide spanning the betaA strand of the proto-oncogene TCL1
Tcl1 is a coactivator of Akt (show AKT1 ELISA Kits) signaling, in normal T- and B-cell development and function.
Detailed mechanism for TCL1-augmented signaling helps explain the delayed occurrence of mature T cell expansions and leukemias despite tumorigenic TCL1 dysregulation that begins in early thymocytes.
TCL1A is not only a useful biomarker for prognostic evaluation in stage II/III colorectal cancer patients.
Our results suggest that intratumoral TCL1A+ B cells are important for controlling cervical cancer development.
Our study suggests that TCL1 expression profile may have a role in the prediction of overall outcome in patient with MCL (show FH ELISA Kits) and call for prospective studies.
We investigated TCL1 expression at the protein level in the bone marrow of a series of 59 patients with Waldenstrom macroglobulinemia: 76% of patients expressed TCL1, which appeared to be associated with a pejorative prognostic impact.
Suggest miR (show MLXIP ELISA Kits)-181b as therapeutic target for chronic lymphocytic leukemia in the Emicro-TCL1 mouse model.
High TCL1A expression is associated with chronic lymphocytic leukemia.
Polymorphic genetic variations of cytochrome P450 19A1 (show CYP19A1 ELISA Kits) and T-cell leukemia 1A genes in the Tamil population
Peptide-based TCL1-interphase mimics were potent in steric AKT (show AKT1 ELISA Kits) antagonization.
demonstrated that miR (show MLXIP ELISA Kits)-3676 targets three consecutive 28-bp repeats within 3'UTR (show UTS2R ELISA Kits) of TCL1 and showed that miR (show MLXIP ELISA Kits)-3676 is a powerful inhibitor of TCL1
Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15 (show CDKN2B ELISA Kits);q32) [TCRgamma-TCL1A translocation] confirmed by FISH.
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998
T-cell leukemia/lymphoma 1A
, T-cell lymphoma-1
, T-cell leukemia/lymphoma protein 1A
, T-cell lymphoma breakpoint 1
, oncogene TCL-1
, oncogene TCL1
, protein p14 TCL1
, T-cell leukemia/lymphoma protein 1A (P14 TCL1 protein) (TCL1 oncogene) (TCL-1 protein)