Browse our TET1 Proteins (TET1)

Full name:
Tet Methylcytosine Dioxygenase 1 Proteins (TET1)
On are 2 Tet Methylcytosine Dioxygenase 1 (TET1) Proteins from 2 different suppliers available. Additionally we are shipping TET1 Antibodies (81) and many more products for this protein. A total of 85 TET1 products are currently listed.
2510010B09Rik, AA517754, bA119F7.1, BB001228, Cxxc6, D10Ertd17e, LCX, mKIAA1676
list all proteins Gene Name GeneID UniProt
TET1 80312 Q8NFU7
TET1 52463 Q3URK3
Rat TET1 TET1 309902  

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TET1 Proteins (TET1) by Origin

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More Proteins for TET1 Interaction Partners

Human Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. Compared to normal tissues, the expression level of TET1 in colorectal cancer (CRC (show CALR Proteins)) was significantly lower. Moreover, in vitro studies showed that TET1 could inhibit cell growth and promote cell metastasis and invasion.TET1 played a multifaceted role in the pathogenesis of CRC (show CALR Proteins), and thereby resulting in multiple effects on tumor progression.

  2. In this study, we show that hypercholesterolemia increases the incidence and pathologic severity of colorectal neoplasia in two independent mouse models. Hypocholesterolemia induced an oxidant stress-dependent increase in miR101c, which downregulated Tet1 in hematopoietic stem cells (HSC (show FUT1 Proteins)), resulting in reduced expression of genes critical to natural killer T cell (NKT (show SLC22A6 Proteins)) and gamma delta T-cell differentiation

  3. miR (show MLXIP Proteins)-29b targets the DNA-demethylating enzyme, TET1, for downregulation resulting in decreased 5-hmC epigenetic modifications.

  4. The results of the present study demonstrate that TET1 might function as one of the key molecules in SOD3 (show SOD3 Proteins) expression through its 5mC hydroxylation in A549 cells.

  5. Results show that the levels of TET1 transcript are elevated in medulloblastoma and ependymoma cells may imply that this protein is involved in pathogenesis of the paediatric brain tumours via demethylation of the regulatory elements of the oncogenes promoting initiation and/or progression of these types of cancer.

  6. Loss of TET1 may induce aberrant DNA methylation (show HELLS Proteins) and may attenuate the effect of 5-aza-2'-deoxycytidine in colorectal cancer cells.

  7. our findings reveal that TET1 forms a complex with hMOF (show KAT8 Proteins) to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.

  8. FOXA1 (show FOXA1 Proteins) is not only able to recognize but also remodel the epigenetic signatures at lineage-specific enhancers, which is mediated, at least in part, by a feed-forward regulatory loop between FOXA1 (show FOXA1 Proteins) and TET1.

  9. that miR (show MLXIP Proteins)-30a could inhibit TET1 expression through base pairing with complementary sites in the 3'untranslated region to regulate Drp-1 (show CRMP1 Proteins) promoter hydroxymethylation.

  10. We found that TET1 and TET2 messenger RNA expression was lower and TET3 was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 and TET2 was found, but no correlation was observed in the case of TET3.

Mouse (Murine) Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. Isoform switch of TET1 regulates DNA demethylation and mouse development.

  2. Low TET1 expression is associated with Liver Cancer.

  3. Zfp281 interacts with Tet1, but not Tet2, and its direct transcriptional target, miR-302/367, to negatively regulate Tet2 expression to establish and maintain primed pluripotency.

  4. Our data implicate TET enzymes ( TET1 and TET2 )in the evolutionary dynamics of TEs (show TES Proteins), both in the context of exaptation processes and of retrotransposition control. The dual role of TET action on LINE-1s may reflect the evolutionary battle between TEs (show TES Proteins) and the host

  5. our findings reveal that TET1 forms a complex with hMOF (show KAT8 Proteins) to modulate its function and the level of H4K16Ac ultimately affect gene expression and DNA repair.

  6. a complex relationship between ten-eleven translocation (TET) proteins and retrotransposons in mouse embryonic stem cells (ESCs (show NR2E3 Proteins)), implicating TETs as enhancers in the exaptation and function of retroelement sequences.

  7. Tet1-mediated DNA hydroxymethylation plays a critical role in the epigenetic regulation of the Wnt (show WNT2 Proteins) pathway in intestinal stem and progenitor cells and consequently in the self-renewal of the intestinal epithelium.

  8. The current Tet1 RefSeq mRNA sequences (NM_001253857.1 and NM_027384.1) start with the coding sequence and lack the 5'UTR. We describe in this paper two previously unannotated alternative 5'UTR exons in the gene Tet1. Transcripts initiated from exon 1b are expressed highly in mouse embryonic stem cells, whereas those initiated from exon 1a are constitutively expressed at low levels in adult tissues.

  9. results suggest that the miR (show MLXIP Proteins)-29a-Tet1 pathway upregulates MyoD (show MYOD1 Proteins) expression and conversely downregulates Cdk6 (show CDK6 Proteins) expression

  10. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Proteins)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Proteins) and DNMT3B (show DNMT3B Proteins); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Proteins) and demethylation crucial to regulation of key signalling pathways in early body plan formation

Cow (Bovine) Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. TET3 dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Proteins).

TET1 Protein Profile

Protein Summary

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.

Alternative names and synonyms associated with TET1

  • tet methylcytosine dioxygenase 1 (TET1)
  • tet methylcytosine dioxygenase 1 (Tet1)
  • tet oncogene 1 (TET1)
  • 2510010B09Rik protein
  • AA517754 protein
  • bA119F7.1 protein
  • BB001228 protein
  • Cxxc6 protein
  • D10Ertd17e protein
  • LCX protein
  • mKIAA1676 protein

Protein level used designations for TET1

CXXC finger 6 , CXXC zinc finger 6 , CXXC-type zinc finger protein 6 , leukemia-associated protein with a CXXC domain , methylcytosine dioxygenase TET1 , ten-eleven translocation 1 gene protein , ten-eleven translocation-1 , tet oncogene 1 , ten-eleven translocation 1 gene protein homolog , tet methylcytosine dioxygenase 1

80312 Homo sapiens
52463 Mus musculus
479229 Canis lupus familiaris
100153073 Sus scrofa
513640 Bos taurus
309902 Rattus norvegicus
423690 Gallus gallus
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