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Browse our TET1 Proteins (TET1)

Full name:
Tet Methylcytosine Dioxygenase 1 Proteins (TET1)
On are 2 Tet Methylcytosine Dioxygenase 1 (TET1) Proteins from 2 different suppliers available. Additionally we are shipping TET1 Antibodies (78) and many more products for this protein. A total of 82 TET1 products are currently listed.
2510010B09Rik, AA517754, bA119F7.1, BB001228, Cxxc6, D10Ertd17e, LCX, mKIAA1676
list all proteins Gene Name GeneID UniProt
TET1 80312 Q8NFU7
TET1 52463 Q3URK3
Rat TET1 TET1 309902  

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TET1 Proteins (TET1) by Origin

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More Proteins for TET1 Interaction Partners

Human Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. that miR (show MLXIP Proteins)-30a could inhibit TET1 expression through base pairing with complementary sites in the 3'untranslated region to regulate Drp-1 (show CRMP1 Proteins) promoter hydroxymethylation.

  2. We found that TET1 and TET2 messenger RNA expression was lower and TET3 was higher in cancers compared to normal tissues. Positive correlation between 5-hmC and the relative expression of TET1 and TET2 was found, but no correlation was observed in the case of TET3.

  3. Increased TET1 induced re-expression of vimentin (show VIM Proteins) through active DNA demethylation, and cause partial epithelial-to-mesenchymal (EMT (show ITK Proteins)) in A2780 cells.

  4. these findings suggest that Tet1 expression plays a critical role in metastasis of lung cancer cells by suppression of invasion and epithelial-mesenchymal transition (EMT (show ITK Proteins)).

  5. TET1, TET2, and TET3 genes are downregulated in endometriosis.

  6. Noncovalent binding of ADP-ribose polymers with TET1 catalytic domain decreases TET1 hydroxylase activity while the covalent PARylation stimulates TET1 enzyme. In addition, TET1 activates PARP-1/ARTD1 (show PARP1 Proteins) independently of DNA breaks.

  7. Expression levels of TET1 are low in renal carcinoma, particularly in high grade tumors.

  8. our study demonstrated that DNA hypomethylation at the TET1 promoter was associated with childhood asthma in African Americans.

  9. Identify of MLL (show MLL Proteins)-fusion/MYC (show MYC Proteins) dash, verticalmiR-26 dash, verticalTET1 signaling circuit in MLL (show MLL Proteins)-rearranged acute myeloid leukemia (show BCL11A Proteins).

  10. The expression (mRNA and protein levels) of DNMT1 (show DNMT1 Proteins) and TET1 is increased in PFC (show CFP Proteins) of SZ and BP disorder patients.

Mouse (Murine) Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. results suggest that the miR (show MLXIP Proteins)-29a-Tet1 pathway upregulates MyoD (show MYOD1 Proteins) expression and conversely downregulates Cdk6 (show CDK6 Proteins) expression

  2. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty (show LEFTY2 Proteins)-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (show DNMT3A Proteins) and DNMT3B (show DNMT3B Proteins); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (show HELLS Proteins) and demethylation crucial to regulation of key signalling pathways in early body plan formation

  3. TET1 accelerates neurogenesis onset time in the fetal brain.TET1 appears to not be associated with gliogenesis during fetal brain development.

  4. Reprogramming of spermatogonial stem cells from Tet1 and Tet2 double knockout mice however lacked demethylation of H19 (show NCKAP1 Proteins) imprinting control regions.

  5. The critical roles of TET1/2 individually.

  6. These results uncover the hypermethylation of DNA methylation canyons as the genomic key feature of Tet1/Tet2 double-knockout mouse embryonic fibroblasts.

  7. Lin28A (show LIN28A Proteins) binds active promoters and recruits Tet1 to regulate gene expression via epigenetic DNA modifications.

  8. Knockdown of Tet1 and Tet3 by RNAi in ex vivo cerebellar slice cultures inhibits dendritic arborization of developing cerebellar granule cells, a critical step in circuit formation

  9. findings demonstrate that DAZL (show DAZL Proteins) associates with mRNA of Tet1, a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 mRNA translation; DAZL (show DAZL Proteins) enhances TET1-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state

  10. The miR (show MLXIP Proteins)-29b/Tet1 regulatory axis promotes the mesendoderm lineage formation by inducing the Nodal signaling pathway and repressing the key target of the active demethylation pathway, thymine DNA glycosylase (show TDG Proteins).

Cow (Bovine) Tet Methylcytosine Dioxygenase 1 (TET1) interaction partners

  1. TET3 dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA (show AICDA Proteins).

TET1 Protein Profile

Protein Summary

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification.

Alternative names and synonyms associated with TET1

  • tet methylcytosine dioxygenase 1 (TET1)
  • tet methylcytosine dioxygenase 1 (Tet1)
  • tet oncogene 1 (TET1)
  • 2510010B09Rik protein
  • AA517754 protein
  • bA119F7.1 protein
  • BB001228 protein
  • Cxxc6 protein
  • D10Ertd17e protein
  • LCX protein
  • mKIAA1676 protein

Protein level used designations for TET1

CXXC finger 6 , CXXC zinc finger 6 , CXXC-type zinc finger protein 6 , leukemia-associated protein with a CXXC domain , methylcytosine dioxygenase TET1 , ten-eleven translocation 1 gene protein , ten-eleven translocation-1 , tet oncogene 1 , ten-eleven translocation 1 gene protein homolog , tet methylcytosine dioxygenase 1

80312 Homo sapiens
52463 Mus musculus
479229 Canis lupus familiaris
100153073 Sus scrofa
513640 Bos taurus
309902 Rattus norvegicus
423690 Gallus gallus
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