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The amino acid sequence of an aryl hydrocarbon receptor repressor (AHRR)cDNA was determined encoding an 85.3-kDa protein sharing 52-55% identity with the bHLH/PAS (show PASK ELISA Kits) domains of other AHRRs.
We found that a burden of low-frequency coding variants in N4BP2 (show N4BP2 ELISA Kits), CDSN (show CDSN ELISA Kits), PRTG (show PRTG ELISA Kits), and AHRR (show CYP1A1 ELISA Kits) were associated with increased risk of Nonsyndromic cleft lip with or without cleft palate (NSCL (show NHLH1 ELISA Kits)/P) . Low-frequency variants in other genes were associated with decreased risk of NSCL (show NHLH1 ELISA Kits)/P. These results demonstrate that low-frequency variants contribute to the genetic etiology of NSCL (show NHLH1 ELISA Kits)/P
The structure clearly disclosed that AhRR (show CYP1A1 ELISA Kits) competitively represses AhR (show AHR ELISA Kits) binding to ARNT (show ARNT ELISA Kits) and target DNA and further suggested the existence of an AhRR (show CYP1A1 ELISA Kits)-ARNT (show ARNT ELISA Kits)-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR (show CYP1A1 ELISA Kits) represses AhR (show AHR ELISA Kits)-mediated gene transcription.
Prospective study demonstrated that AHRR (show CYP1A1 ELISA Kits) and F2RL3 (show F2RL3 ELISA Kits) methylation levels had inverse relationships with self-reported smoking status and accurately discriminated for both current- and former- smoking. Moreover, methylation markers distinguished former smokers from never-smokers with high accuracy and significantly associated with an increased risk of lung cancer.
In conclusion, we found that AHRR (show CYP1A1 ELISA Kits) (cg05575921) hypomethylation was associated with smoking, high smoking-related morbidity and with high all-cause mortality.
The findings suggest that AHRR plays distinct roles in kidney functions and hemoglobin values.
Maternal-smoking sensitive CpG sites in newborns were significantly associated with cg05575921 SNP located proximal to AHRR (show CYP1A1 ELISA Kits).
This study demonstrated that the polymorphisms of aromatic hydrocarbon receptor repressor rs2292596 was significant with genetic susceptibility to rheumatoid arthritis patients; furthermore, it suggests the G allele of aromatic hydrocarbon receptor rs2292596 might be associated with a dangerous effect on rheumatoid arthritis in Han Chinese populations.
Study demonstrates that AHRR (show CYP1A1 ELISA Kits) and F2RL3 (show F2RL3 ELISA Kits) methylation are strong predictors individually for lung cancer development.
In the AHRRNCOA2 protein, the Cterminal part of AHRR (show CYP1A1 ELISA Kits) is replaced by the Cterminal part of NCOA2 (show NCOA2 ELISA Kits) which contains two activation domains
AHRR (show CYP1A1 ELISA Kits) methylation in monocytes may be a part of the biological link between cigarette smoking and atherosclerosis
Suggest AHRR mediates dioxin inhibition of lactation by blocking transcription of beta-casein (show CSN2 ELISA Kits).
Immortalized TiPARP (show Tiparp ELISA Kits)(-/-) mouse embryonic fibroblasts (MEFs) and AHRR(-/-) MEFs exhibited enhanced AHR (show AHR ELISA Kits) transactivation.
AhRR mRNA expression pattern in untreated C57BL/6 mice varies across tissues with high levels in hearts and brains
The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
aryl hydrocarbon receptor repressor
, aryl-hydrocarbon receptor repressor
, arylhydrocarbon receptor repressor
, aryl hydrocarbon receptor repressor-like
, ahR repressor
, aryl hydrocarbon hydroxylase regulator
, class E basic helix-loop-helix protein 77
, dioxin receptor repressor
, aryl hydrocarbon hydroxylase
, cytochrome P1-450
, cytochrome P450 1A1
, cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)
, cytochrome P450, 1a1
, cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c)
, cytochrome P450-C
, cytochrome P450MT2
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, xenobiotic monooxygenase