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Human AKR1C2 ELISA Kit for Sandwich ELISA - ABIN1117945
Kuang, Zhou, Li, Ren, Li, Wang, Li, Tang, Zhang, Zhao: Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients. in Lung cancer (Amsterdam, Netherlands) 2012
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The reduction of DHT obese homozygotic twins could be linked to its increased degradation by AKR1C2 and HSD11B1 (show HSD11B1 ELISA Kits), and increased estrogen levels could be linked to increased adiposity-related expression of aromatase (show CYP19A1 ELISA Kits) in adipose tissue.
the present study suggests that AKR1C1 (show DDH ELISA Kits), AKR1C2, AKR1C3 (show AKR1C3 ELISA Kits), and AKR1C4 (show AKR1C4 ELISA Kits) are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
We identified two powerful genes in the liver cancer metastasis process, AEG-1 (show MTDH ELISA Kits) and AKR1C2.
Identify two novel factors, AKR1C2 (positive factor) and NF1 (show NF1 ELISA Kits) (negative factor), as the AEG-1 (show MTDH ELISA Kits) downstream players in the process of metastasis in liver cancer.
The endogenous HMOX1 (show HMOX1 ELISA Kits) gene but not the AKR1C2 gene is strongly repressed by Bach1 (show BACH1 ELISA Kits) in HaCaT keratinocytes.
In model cell lines of endometrial cancer, AKR1C2 and SRD5A1 (show SRD5A1 ELISA Kits) have crucial roles in progesterone metabolism.
Significantly higher levels of SRD5A1 (show SRD5A1 ELISA Kits), AKR1C2, AKR1C3 (show AKR1C3 ELISA Kits), and HSD17B10 (show HSD17B10 ELISA Kits) mRNA were however found in bone metastases than in non-malignant and/or malignant prostate tissue
The V54L mutation significantly decreases the 3alpha-hydroxysteroid dehydrogenase activity of DDH2 for the reduction of dihydrotestosterone.
DDH2 expression might be a potential predictor and monitor of cisplatin efficacy in advanced NSCLC patients.
Data suggest that interleukin-1beta facilitates progesterone metabolism in cervical fibroblasts by regulating expression of AKR1C1 (show DDH ELISA Kits) and AKR1C2.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
, aldo-keto reductase family 1 member C2
, chlordecone reductase homolog HAKRD
, dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III
, pseudo-chlordecone reductase
, trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
, type II dihydrodiol dehydrogenase
, 17-alpha-hydroxysteroid dehydrogenase
, 3(or 17)-alpha-hydroxysteroid dehydrogenase
, 3-alpha-hydroxysteroid dehydrogenase
, aldo-keto reductase family 1 member C21
, aldo-keto reductase family 1, member C21