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We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
Data suggest that activated ARF6 controls GNAQ (show GNAQ ELISA Kits) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
expression and activation of LHCGR (show LHCGR ELISA Kits) and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR (show LHCGR ELISA Kits) internalization is unaltered
The Squamous cell carcinoma of the tongue cell line SCC (show CYP11A1 ELISA Kits)-9, which overexpress Arf6 and AMAP1 (show ASAP1 ELISA Kits), also expressed EPB41L5 (show EPB41L5 ELISA Kits) at high levels to promote invasiveness, whereas the weakly invasive SCC (show CYP11A1 ELISA Kits)-25 cells did not express EPB41L5 (show EPB41L5 ELISA Kits) at notable levels.
both Arf6 activation through GluN2B (show GRIN2B ELISA Kits)-BRAG1 (show IQSEC2 ELISA Kits) during early development and the transition from BRAG1 (show IQSEC2 ELISA Kits)- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
results provide evidence for a novel Arf6 activation mechanism by Dyn2 (show DNM2 ELISA Kits) through EFA6B and EFA6D in CME in a manner dependent upon the GTPase (show RACGAP1 ELISA Kits) activity of Dyn2 (show DNM2 ELISA Kits)
Mutant p53 (show TP53 ELISA Kits), which is known to support tumorigenesis via MVP (show MVP ELISA Kits), promotes Arf6 activation.
The expression of miR (show MLXIP ELISA Kits)-206 by HUVECs reduced exosome production by regulating ADP-Ribosylation Factor 6 (ARF6) and sodium/calcium exchanger 1 (NCX1 (show SLC8A1 ELISA Kits)).
The role of EGFR (show EGFR ELISA Kits)-ARF6 signaling in BA.
Data suggest ADAP2 (show ADAP2 ELISA Kits) (an interferon-beta (show IFNB1 ELISA Kits) stimulated gene) disrupts pathogenic internalization of some RNA viruses/virions (dengue, vesicular stomatitis) by altering ADP ribosylation factor 6-mediated processes including up-regulation of pinocytosis.
A dominant negative mutant of Arf6 blocks direct transport of APP (show APP ELISA Kits) to lysosomes, but does not affect classical endocytosis to endosomes.
Peripheral ARNO (show CYTH2 ELISA Kits) promotes clathrin assembly through its GEF (show ARHGEF2 ELISA Kits) activity for Arf6.
In platelet-specific Arf6 knockout mice,Arf6 KO platelets had less associated Fg suggesting that Arf6 affects alphaIIbbeta3-mediated Fg uptake and/or storage. They were also defective in FITC-Fg uptake and storage.
findings show for the first time that Ang II (show AGT ELISA Kits) receptor signaling to beta-arrestin regulates ARF6 activation. These proteins together control receptor endocytosis and ultimately cell migration.
The role of ARF-6 and Annexin A2 (show ANXA2 ELISA Kits) in the invasion of mammalian cells by T. cruzi amastigotes.
Findings demonstrate that Arf6 in neurons of the CNS plays an important role in oligodendrocyte precursor cells migration by regulating secretion of FGF-2 (show FGF2 ELISA Kits) from neurons, thereby contributing to the axon myelination.
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Arf6 is required for hepatocyte growth factor (HGF (show HGF ELISA Kits))-induced tumour neoangiogenesis and growth.
the activation-inactivation cycles of Rab35 (show RAB35 ELISA Kits) and ARF6 are required for the uptake of zymosan and that ACAP2 (show ACAP2 ELISA Kits) is an important component that links Rab35 (show RAB35 ELISA Kits)/ARF6 signaling during phagocytosis of zymosan.
Arf6 plays an important role in oligodendrocyte precursor cells migration through regulation of FGF-2 (show FGF2 ELISA Kits) secretion during neuronal development.
Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
PPAR (show PPARA ELISA Kits) expression, the activity of its target gene AOX (show ACOX1 ELISA Kits), and peroxisomal biogenesis are developmentally modulated in zebrafish
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP ribosylation factor III
, ADP-ribosylation factor 6
, peroxisome proliferator-activated receptor gamma