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We show that Arf6 functions in the adult nervous system to control ethanol-induced behavior.
Cindr-mediated regulation of Arf6 is a widely used mechanism in emerging epithelia.
ARF6 promotes rapid recycling of endosomal membrane stores during spermatocyte cytokinesis, which is critical for rapid cleavage furrow ingression.
ARF6 was a downstream target of Kras/ERK (show EPHB2 ELISA Kits) signaling pathway, and the strong correlation of expression between Kras and ARF6 in the TCGA dataset further confirmed this observation.
FRMD4A RNAi or inhibition of cytohesins strongly upregulated secretion of endogenous tau. These results suggest that FRMD4A, a genetic risk factor for late-onset Alzheimer's disease, regulates tau secretion by activating cytohesin-Arf6 signaling.
Macrophage tissue factor (show F3 ELISA Kits) prothrombotic activity is regulated by integrin-alpha4/arf6 trafficking.
Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 (show RAB35 ELISA Kits) during infection.
These results identify RalF as the first bacterial effector to directly activate Arf6, a process that initiates alterations in phosphoinositol metabolism critical for a lineage-specific Rickettsia entry mechanism.
Data suggest that activated ARF6 controls GNAQ (show GNAQ ELISA Kits) and b-catenin signaling by regulating protein trafficking between intracellular compartments. Blocking ARF6 with a small-molecule inhibitor reduces uveal melanoma cell proliferation and tumorigenesis in a mouse model.
expression and activation of LHCGR (show LHCGR ELISA Kits) and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR (show LHCGR ELISA Kits) internalization is unaltered
The Squamous cell carcinoma of the tongue cell line SCC (show CYP11A1 ELISA Kits)-9, which overexpress Arf6 and AMAP1 (show ASAP1 ELISA Kits), also expressed EPB41L5 (show EPB41L5 ELISA Kits) at high levels to promote invasiveness, whereas the weakly invasive SCC (show CYP11A1 ELISA Kits)-25 cells did not express EPB41L5 (show EPB41L5 ELISA Kits) at notable levels.
both Arf6 activation through GluN2B (show GRIN2B ELISA Kits)-BRAG1 (show IQSEC2 ELISA Kits) during early development and the transition from BRAG1 (show IQSEC2 ELISA Kits)- to BRAG2-dependent Arf6 signaling induced by the GluN2 subunit switch are critical for the development of mature glutamatergic synapses.
results provide evidence for a novel Arf6 activation mechanism by Dyn2 (show DNM2 ELISA Kits) through EFA6B and EFA6D in CME in a manner dependent upon the GTPase (show RACGAP1 ELISA Kits) activity of Dyn2 (show DNM2 ELISA Kits)
The present study provided evidence that BRAG2a is a novel component of the photoreceptor dystrophin (show DMD ELISA Kits)-associated glycoprotein complex (DGC (show GGCX ELISA Kits)), suggesting functional involvement of the BRAG2a-Arf6 pathway downstream of the DGC (show GGCX ELISA Kits).
cycling between active and inactive forms of Arf6, which is precisely regulated by ACAP3 (show Acap3 ELISA Kits) in concert with a guanine-nucleotide-exchange factor (show ARHGEF12 ELISA Kits)(s), seems to be required for neurite outgrowth of hippocampal neurons
ARF6-dependent pathway is the predominant route responsible for the ABCA1 (show ABCA1 ELISA Kits) internalization and degradation, whereas ARF6-independent endocytic pathways may contribute to ABCA1 (show ABCA1 ELISA Kits) recycling and efflux of intracellular cholesterol.
These findings suggest that SDCCAG3 (show SDCCAG3 ELISA Kits) might function in endosomal trafficking downstream of Arf6.
Peripheral ARNO (show CYTH2 ELISA Kits) promotes clathrin assembly through its GEF (show ARHGEF2 ELISA Kits) activity for Arf6.
In platelet-specific Arf6 knockout mice,Arf6 KO platelets had less associated Fg suggesting that Arf6 affects alphaIIbbeta3-mediated Fg uptake and/or storage. They were also defective in FITC-Fg uptake and storage.
findings show for the first time that Ang II (show AGT ELISA Kits) receptor signaling to beta-arrestin regulates ARF6 activation. These proteins together control receptor endocytosis and ultimately cell migration.
The role of ARF-6 and Annexin A2 (show ANXA2 ELISA Kits) in the invasion of mammalian cells by T. cruzi amastigotes.
Pparg pathway acts on cephalic neural crest to direct adipocyte differentiation at the expense of osteoblast formation
PPAR (show PPARA ELISA Kits) expression, the activity of its target gene AOX (show ACOX1 ELISA Kits), and peroxisomal biogenesis are developmentally modulated in zebrafish
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.
ADP ribosylation factor III
, ADP-ribosylation factor 6
, peroxisome proliferator-activated receptor gamma