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Human CLTB Protein expressed in Escherichia coli (E. coli) - ABIN1098357
von Kleist, Stahlschmidt, Bulut, Gromova, Puchkov, Robertson, MacGregor, Tomilin, Tomlin, Pechstein, Chau, Chircop, Sakoff, von Kries, Saenger, Kräusslich, Shupliakov, Robinson, McCluskey, Haucke: Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. in Cell 2011
Show all 2 references for ABIN1098357
Data indicate that clathrin-mediated endocytosis of proto-oncogene (show RAB1A Proteins) protein erbB-3 (ErbB3 (show ERBB3 Proteins)) is depending on epsin-1 (show EPN1 Proteins).
Supporting a physiological role for CLC (show CLC Proteins) in migration, the CLCb isoform of CLC (show CLC Proteins) is upregulated in migratory human trophoblast cells during uterine invasion.
Data suggest that clathrin heavy chains bound to light chains (LC) a and b contribute to pit formation, but the affinity of LCa-free HC in pits is reduced, and the Ca(2+)- and ATP-mediated control of clathrin function is lost.
Structure of clathrin coat with bound Hsc70 (show HSPA8 Proteins) and auxilin (show DNAJC6 Proteins).
Based on circular dichroism data, mapping and mutagenesis, bovine LCa and LCb were represented as alpha-helices, aligned along the heavy chain. A structural model of the interaction was generated with new implications for LC control of clathrin assembly.
CLTLB purified from bovine brain postmicrotubule supernatant and identified by mass spectrometry potently inhibited a catalytic activity of a major protein phosphatase (PP) that was copurified with microtubules and recognized by antiPP1 antibodies
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants.
clathrin, light chain (Lcb)
, clathrin light chain B
, clathrin, light polypeptide (Lcb)
, Clathrin light chain B
, clathrin, light polypeptide B (light chain B)