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anti-Rat (Rattus) DNAJA3 Antibodies:
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Human Polyclonal DNAJA3 Primary Antibody for EIA, WB - ABIN951939
Qian, Perchiniak, Sun, Groden: The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis. in Gastroenterology 2010
Show all 2 references for 951939
Human Polyclonal DNAJA3 Primary Antibody for WB - ABIN658587
Kurzik-Dumke, Hörner, Czaja, Nicotra, Simiantonaki, Koslowski, Natali: Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor. in International journal of molecular medicine 2007
Show all 2 references for 658587
Human Polyclonal DNAJA3 Primary Antibody for IF, WB - ABIN522528
Carnini, Scott, Ahrendt, Proft, Winkfein, Kim, Colicos, Braun: Cell line specific modulation of extracellular a?42 by Hsp40. in PLoS ONE 2012
Human Monoclonal DNAJA3 Primary Antibody for IP, WB - ABIN180463
Syken, De-Medina, Münger: TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. in Proceedings of the National Academy of Sciences of the United States of America 1999
Dnaja3 is crucial for mitochondrial biogenesis through its chaperone activity on Polga (show POLG Antibodies) and has a role in preventing dilated cardiomyopathy
Tid1 is critical for early mammalian development, most likely for its function in sustaining embryonic-cell survival, which requires its association with Hsp70 (show HSP70 Antibodies).
It is proposed that Tid1 contributes to cell aging by acting as a repressor of NF-kappa B (show NFKB1 Antibodies) signaling.
Overexpression of the N-terminal half of Tid1 induced agrin (show AGRN Antibodies)- and MuSK (show MUSK Antibodies)-independent phosphorylation and clustering of AChRs. These results demonstrate that Tid1 is an essential component of the agrin (show AGRN Antibodies) signaling pathway, crucial for synaptic development.
Impaired stoichiometry between mtHsp40 and mtHsp70 (show HSPA9 Antibodies) promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function.
The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB (show NFKB1 Antibodies) Signaling.
Tid1 increases autophagic flux by interacting with the Beclin 1-containing autophagy protein complex.
TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition
Tid1 acts as a tumor suppressor by inhibiting EGFR (show EGFR Antibodies) signaling through interaction with EGFR (show EGFR Antibodies)/HSP70 (show HSP70 Antibodies)/HSP90 (show HSP90 Antibodies) and enhancing EGFR (show EGFR Antibodies) ubiquitinylation and degradation.
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1 (show DNM1L Antibodies))-depedendent mitochondrial fragmentation and decreased cell viability.
loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin
Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 (show ERBB2 Antibodies) protein, and that both are significant prognostic indicators of breast cancer patient survival.
findings denote hTid-1(S) as an essential regulatory component of MetR signaling
hTid1 negatively regulates the expression and transcriptional activity of STAT5b (show STAT5B Antibodies) and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b (show STAT5B Antibodies).
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
dnaJ homolog subfamily A member 3, mitochondrial
, DnaJ (Hsp40) homolog, subfamily A, member 3
, dnaJ protein Tid-1
, tumorous imaginal discs protein Tid56 homolog
, hepatocellular carcinoma-associated antigen 57