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Dnaja3 is crucial for mitochondrial biogenesis through its chaperone activity on Polga (show POLG Proteins) and has a role in preventing dilated cardiomyopathy
Tid1 is critical for early mammalian development, most likely for its function in sustaining embryonic-cell survival, which requires its association with Hsp70 (show HSP70 Proteins).
It is proposed that Tid1 contributes to cell aging by acting as a repressor of NF-kappa B (show NFKB1 Proteins) signaling.
Overexpression of the N-terminal half of Tid1 induced agrin (show AGRN Proteins)- and MuSK (show MUSK Proteins)-independent phosphorylation and clustering of AChRs. These results demonstrate that Tid1 is an essential component of the agrin (show AGRN Proteins) signaling pathway, crucial for synaptic development.
Impaired stoichiometry between mtHsp40 and mtHsp70 (show HSPA9 Proteins) promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function.
The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB (show NFKB1 Proteins) Signaling.
Tid1 increases autophagic flux by interacting with the Beclin 1-containing autophagy protein complex.
TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition
Tid1 acts as a tumor suppressor by inhibiting EGFR (show EGFR Proteins) signaling through interaction with EGFR (show EGFR Proteins)/HSP70 (show HSP70 Proteins)/HSP90 (show HSP90 Proteins) and enhancing EGFR (show EGFR Proteins) ubiquitinylation and degradation.
Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1 (show DNM1L Proteins))-depedendent mitochondrial fragmentation and decreased cell viability.
loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin
Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 (show ERBB2 Proteins) protein, and that both are significant prognostic indicators of breast cancer patient survival.
findings denote hTid-1(S) as an essential regulatory component of MetR signaling
hTid1 negatively regulates the expression and transcriptional activity of STAT5b (show STAT5B Proteins) and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b (show STAT5B Proteins).
This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
dnaJ homolog subfamily A member 3, mitochondrial
, DnaJ (Hsp40) homolog, subfamily A, member 3
, dnaJ protein Tid-1
, tumorous imaginal discs protein Tid56 homolog
, hepatocellular carcinoma-associated antigen 57