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four oncogenic ETS (show ETS1 Proteins) (ERG (show ERG Proteins), ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins), and ETV5), and no other ETS (show ETS1 Proteins), interact with the Ewing's sarcoma breakpoint protein, EWS (show EWSR1 Proteins).
Novel ETV5 SNP rs7647305 is associated with childhood hypertension adjusted by obesity.
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins) and ETV5.
the prostate cancer-related oncogenic E26 transformation-specific (ETS (show ETS1 Proteins)) transcription factors, ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins), and ETV5, were required for TAZ (show TAZ Proteins) gene transcription in PC3 (show PCSK1 Proteins) prostate cancer cells
MiR (show MLXIP Proteins)-200b inhibition by transfection in MCF-7 markedly decreased miR (show MLXIP Proteins)-200b level, elevated ERM expression, and enhanced cell migration and invasion. MiR (show MLXIP Proteins)-200b overexpression in MDA-MB-231 obviously increased miR (show MLXIP Proteins)-200b level, reduced ERM expression, and weakened cell migration and invasion.
Resistin (show RETN Proteins), a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation
ERM proteins contribute toward accelerated CD44 (show CD44 Proteins) shedding by MT1-MMP (show MMP14 Proteins) through ERM protein-mediated interactions between their cytoplasmic tails.
Our results reveal a novel ERM-based spatial mechanism that is coopted by DLBCL cells to sustain tumor cell growth and survival.
Increase of ETV5 protein expression is associated with endometrial cancer invasion.
developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1 (show ETV1 Proteins), ETV4 (show ETV4 Proteins), and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa (show FLVCR1 Proteins) specimens using RNA probes
etv5a and etv4 (show ETV4 Proteins) have roles in mediating epithelial cell fate during zebrafish kidney development
Zebrafish etv5a is essential for the inhibition of ventral mesoderm cell proliferation and for the formation of the hemato-vascular lineage.
SOX9 (show SOX9 Proteins) regulation of ETV5 contributes to the control of male fertility
this study shows that Etv5 plays a crucial role in regulating IL-10 (show IL10 Proteins) production in Th2 cells by facilitating the binding of IL-10 (show IL10 Proteins)-inducing transcription factors at the Il10 (show IL10 Proteins) locus
findings demonstrate that ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation
substrate that mediates RFWD2 function in lung branching
bioinformatic analysis, real-time PCR, and luciferase assay validated that AK015322 serves as a decoy of microRNA-19b-3p (miR (show MLXIP Proteins)-19b-3p), antagonizes its function, and attenuates the repression of its endogenous target transcriptional factor Ets-variant 5 (ETV5) which was a pivotal gene for spermatogonial stem cell self-renewal
Further investigations identified Pak1 (show PAK1 Proteins)-ERM as a downstream signaling cascade upon Rac1 activation in the luminal epithelium necessary for uterine receptivity...Rac1 via P38 MAPK (show MAPK14 Proteins) signaling ensures timely epithelial apoptotic death at postimplantation.
The data of this study suggested that the obesity-associated transcription factor ETV5 normally acts to diminish circulating glucocorticoids.
ETS-related transcription factors ETV4 (show ETV4 Proteins) and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
Noise-decreased levels of ROCK2 results in reduction of phosphorylation of ERM that leads to depolymerization of actin filaments
The transcription factors Etv5 and STAt3 (show STAT3 Proteins) control TH17 cell development and allergic airway inflammation.
Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.
ETS translocation variant 5
, ets-related molecule
, ets-related protein ERM
, ets variant gene 5 (ets-related molecule)
, ets domain protein