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Browse our GRIK4 Proteins (GRIK4)

Full name:
Glutamate Receptor, Ionotropic, Kainate 4 Proteins (GRIK4)
On are 9 Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4) Proteins from 2 different suppliers available. Additionally we are shipping GRIK4 Antibodies (29) and GRIK4 Kits (12) and many more products for this protein. A total of 56 GRIK4 products are currently listed.
6330551K01Rik, EAA1, GluK4, GluRgamma1, GRIK, GRIK4, KA-1, KA1
list all proteins Gene Name GeneID UniProt
GRIK4 2900 Q16099
GRIK4 110637 Q8BMF5
Rat GRIK4 GRIK4 24406 Q01812

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Human Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4) interaction partners

  1. Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes.

  2. Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment.

  3. The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells.

  4. Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation (show BLNK Proteins) and immunoglobulin production.

  5. The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment.

  6. Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate (show GRIN1 Proteins) hypothesis' of psychotic illness.

  7. An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found.

  8. This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function.

Mouse (Murine) Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4) interaction partners

  1. This study demonstrated that mice overexpressing grik4 to directly address circuit dysfunctions associated with ASDs and test specific treatments of autism-related behaviors.

  2. we found that GluK4 is a key mediator of excitotoxic neurodegeneration

  3. This study demonstrated a clear anxiolytic and antidepressant phenotype associated with ablation of Grik4 and a parallel disruption in hippocampal plasticity.

  4. the KA1 KAR (show HSD17B12 Proteins) subunits are expressed in the SG of the Vc in mice and that the expression level of the KA1 KAR (show HSD17B12 Proteins) subunit decreases gradually with postnatal development.

GRIK4 Protein Profile

Protein Summary

This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.

Alternative names and synonyms associated with GRIK4

  • glutamate receptor, ionotropic, kainate 4 (grik4)
  • glutamate receptor, ionotropic, kainate 4 (GRIK4)
  • glutamate receptor, ionotropic, kainate 4 (Grik4)
  • 6330551K01Rik protein
  • EAA1 protein
  • GluK4 protein
  • GluRgamma1 protein
  • GRIK protein
  • GRIK4 protein
  • KA-1 protein
  • KA1 protein

Protein level used designations for GRIK4

glutamate receptor, ionotropic, kainate 4 , ionotropic glutamate receptor subunit KA1 , excitatory amino acid receptor 1 , glutamate receptor KA-1 , glutamate receptor KA1 , glutamate receptor ionotropic, kainate 4 , glutamate receptor, ionotropic kainate 4 , kainate receceptor

556582 Danio rerio
706383 Macaca mulatta
100301969 Xenopus laevis
419751 Gallus gallus
2900 Homo sapiens
610429 Canis lupus familiaris
526363 Bos taurus
110637 Mus musculus
24406 Rattus norvegicus
451620 Pan troglodytes
100715810 Cavia porcellus
101110444 Ovis aries
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