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MINK (show KCNE1 Proteins) plays a functional role in the IRES-mediated translation of EV71 viral RNA and may provide a potential target for the development of specific antiviral strategies against EV71 infection
Misshapen-like kinase 1 (MINK1) is a novel component of striatin (show STRN Proteins)-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.
MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2.
MINK (show KCNE1 Proteins) interaction with Rap2 (show RAP2A Proteins) plays a critical role in maintaining the morphological integrity of dendrites and synaptic transmission.
Analysis of the coding region of the NIK (show MAP3K14 Proteins) gene in progressive supranuclear palsy (PSP (show MSMB Proteins)) patients through single strand conformation polymorphism and direct sequencing does not support a pathogenic role of the NIK (show MAP3K14 Proteins) gene in PSP (show MSMB Proteins).
results suggest that human Misshapen/NIKs-related kinase beta (hMINK beta) plays an important role in cytoskeleton reorganization, cell adhesion, and cell motility(hMINKbeta)
using in vitro dephosphorylation assays, we demonstrate that Mastl (show MASTL Proteins) promotes persistent MPS1 phosphorylation by inhibiting PP2A (show PPP2R2B Proteins)/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 (show CDK1 Proteins) kinase activity. Our findings establish a key regulatory function of the Greatwall (show MASTL Proteins) kinase/Mastl (show MASTL Proteins) - PP2A (show PPP2R2B Proteins)/B55 pathway in preventing premature SAC (show ADCY10 Proteins) silencing
MINK1 may be an important signaling molecule that mediates mitogen-activated protein kinase (show MAPK1 Proteins) signaling and participates in platelet activation and thrombus formation.
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified.
misshapen-like kinase 1 (zebrafish)
, misshapen/NIK-related kinase
, GCK family kinase MINK
, MAPK/ERK kinase kinase kinase 6
, MEK kinase kinase 6
, MEKKK 6
, mitogen-activated protein kinase kinase kinase kinase 6
, serine/threonine protein kinase
, GCK family kinase MiNK
, GCK family kinase
, Misshapen/NIKs-related kinase
, Yeast Sps1/Ste20-related kinase 2
, misshapen-like kinase 1